Updated knowledge about lymphoma pathology has been accumulated ever since the publication of the current WHO classiifcation of lymphomas in 2008. For B-cell non-Hodgkin lymphomas, endeavors have been made for approaching a better classiifcation of those highly aggressive and heterogeneous subtypes (e.g., diffuse large B-cell lymphomas) on the molecular biological basis. In addition, there is a growing interest in understanding and deal-ing with the borders of overt malignant lymphomas and certain clonal lymphproliferative disorders that are not overtly malignant. On the other hand, recent advances in understanding the subsets of T and NK (T/NK)-cell lineage and their differentiation, as well as the genetic aberrations or dysregulated signaling pathways in their neoplastic counterparts, have provided us novel insights into the biology of peripheral T/NK-cell lymphomas. Indolent clonal T/NK-cell prolif-erations, especially those arising from the mucocutaneous sites, have also received increased attention. These advances may contribute to the evolution of the classiifcation of lymphomas.

Due to the high incidence and mortality of digestive system malignant tumor,so it is of great significance to make further research for digestive tract tumor.Platinum drugs,one of the traditional drugs which is used for the chemotherapy for digestive system tumor,which has been extensively applied to the chemotherapy for malignant tumor.However,the resistance to the drugs exerts a serious influence on its curative effect.At present,it is believed that the nucleotide excision repair(NER)constitutes one of the most important mechanisms which results in the resistance to platinum drugs,mainly because it causes the twisting of DNA helix by removing large numbers of platinum compounds.The nucleotide excision repair cross complementation group 1(ERCC1)plays an important role in the process of NER.The different expression of ERCC1 in peripheral blood and tumor tissue of patients with digestive sysem tumor has a close connection with therapeutic effect of the platinum-containing chemotherapy.This article aims to provide an overview of the relation between the ERCC1 research development and the curative effect of cisplatin chemotherapy for digestive system tumor.

Objective To explore the significance of thyroid function determination at the first and second trimesters of pregnan‐cy .Methods Electrochemiluminescence immunoassay was used to detect the levels of TSH ,FT3 and FT4 in first trimester women (T1 group) ,second trimester women (T2 group) and non‐pregnant women (control group) ,respectively .And the results were an‐alyzed .Results There were significant difference in the levels of TSH ,FT3 and FT4 between T1 group and control group (P<0 .05) .The total prevalence rate of thyroid diseases in pregnant women was 28 .85% ,which was significantly higher than that in control group(15 .00% ) ,P<0 .05 .Hypothyroidism and subclinical hypothyroidism were the main forms of thyroid dysfunction in pregnant women .Conclusion The determination of thyroid function at the first and second trimesters of pregnancy will benefit pre‐natal and post‐natal care .

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease in terms of molecular pathogenesis and cell of origin. Earlier prognostic models relied mainly on such clinical variables as age, stage of disease, and performance status, which did not display its heterogeneity. Many studies have reported that some biomarkers could be used for prognostication, while older prognostic models need to be revalidated and modified as improved therapeutic options become available. In this review, we discussed pertinent studies on individual biomarkers and pattern-based biomarker models, with an emphasis on markers evaluated in patients treated with rituximab-containing chemotherapy.

Objective To observe the efficacy of Buyanghuanwu herbal decoctions on microalbuminur in noninsulin-dependent diabetes mellitus. Methods Sixty-six patients with noninsulin-dependent diabetes mellitus patients with 30～300 mg/24 h microalbuminur were randomly divided into the treated group (treated with Buyanghuanwu herbal decoctions) and the control group (treated with injection of Huangqi). The clinical efficacy was observed and levels of blood-fat, hemorheology and microalbuminur were determined. Results The levels of blood-fat, hemorbeology and microalbnminur were decreased in treated group. Comparison between the two groups showed significant difference (P

Objective To observe the clinical efficacy of Cardiotonic Pill and Monopril in treating congestive heart failure disease. Methods Seventy-eight patients with congestive heart failure were randomly divided into two groups. The control group received routine treatment (Monopril), and the treated group were given Cardiotonic Pill besides routine treatment. The symptoms, physical signs and the parameter and classify of cardiac function were evaluated in all patients. Results The symptoms and physical signs after treatment were better than before. The cardiac function were improved. Comparison between the two groups showed difference (P

Objective To discuss the clinical and pathological features of herniation secondary to cerebral infarction. Method Clinical and pathologic characteristics of 50 cases died of herniation due to cerebral infarction were analysised. Results The clinical manifestations,such as consciousness disturbance,pupillary change,hemiplegia or tetraplegia were detected in all 50 cases,the average time from onset to herniation was (3.36?1.12)d,the time herniation to death was 20 h～7 d,average about (1.5?0.98)d. The large size cerebral infarctions caused by internal carotid artery,middle cerebral artery and/or vertebral artery occlusion were pathologically confirmed.hemorrhagic cerebral infarctions caused by cerebral embolism were found in 25 cases and the ischenmic infarctions caused by cerebral thrombosis in 25 caese.Site of infarction were cerebral hemisphere (31 cases), brain stem (15 cases), supratentorial and infratentorial brain (4 cases).Of the 50 cases,36 cases had hippocampal gyrus herniation,36 cases with cerebellur throat-almond herniation,18 cases with central herniation,17 cases with cingulated gyrus herniation,and 27 cases with sphenoidal crest herniation. Usually there were several herniation existing in the same patient. Among 50 cases,11cases had two kinds of herniation,10 cases with three kinds of herniation,9 cases with four kind of herniation, and 5 cases with five kinds of herniation.Conclusions Herniation secondary to cerebral infarction were mainly presented in the large size cerebral infarction caused by internal carotid artery or middle cerebral artery occlusion.the time of herniation was in early stage of disease.Most of patients were hippocampal gyrus herniation and cerebellur throat-almond herniation.Usually there were several herniation existing in the same patient.

Objective To discuss the clinical characteristics and pathological changes of basilar artery aneurysm.Methods The clinical materials and brain topography results were analyzed retrospectively in 4 patients with basilar artery aneurysm.Results The onsets of disease in all cases were acute and common manifestations were coma,positive meningeal irritation sign and ocular dyskinesis.3 cases showed hypertention,2 cases presented with hemiparalysis,all cases died of herniation.3 cases of basilar artery trunk fusiform aneurysm and 1 case of basilar artery furcation saccular aneurysm were detected in autopsy.There were aneurysm rupture,subarachnoid hemorrhage and swell,necrosis,softening,gliosis of brain tissue confirmed pathologically in all cases.Conclusion Hypertension is probably the most important cause of aneurysm rupture.Signs and symptoms of subarachnoid are the most common manifestation when basilar artery aneurysm ruptures with poor prognosis.Herniation is the main cause of death.

Purpose: To study the immunophenotype and the expression of cytotoxic granule proteins of nasal NK/T cell lymphoma and its significance. Methods: 44 cases of nasal NK/T cell lymphoma were studied by the two-step method of DAKO EnVisionTM using a series of antibodies including CD3, CD20, CD43, CD45, CEI45RO, CD56, CD57, CD79?, TIA-1, granzyme-B and perform. Results: All the cases of nasal NK/T cell lymphoma were CD45 positive. 43% of the cases expressed CD3 with positive signal located in the cytoplasm, which was different from peripheral T cell lymphoma. 45% and 52% of the cases were CD43 and CD45RO positive respectively. Cases that reacted to CD56 accounted for 52% of the cases, 43% of which were also positive to CD3. Concerning the reactions to both CD3 and CD56, 10 cases showed CD3 + CD56 + , 13 showed CD3-CD56 + , 9 were CD3 + CD56- and 12 were CD3-CD56-. None of the 44 cases showed positive reaction to CD20, CD79? and CD57. All cases were reactive to TIA-1. 93% and 95% of the cases showed the reactions to granzyme-B and perform. All the controls were negative to TIA-1, granzyme-B and perform. Conclusions: The immunophenotypes of nasal NK/T cell lymphoma showed less consistency. CD56 was not always positive in the cases of this tumor. The different locations of the positive signal to CD3 showed that the cell lineage of this tumor was different from T lymphocytes. The high frequency of the staining by cytotoxic granule proteins, TIA-1, granzyme-B and perform, showed that these cells may have originated from NK cells. The distinctive differences in immunohistochemical staining of cytotoxic granule proteins in nasal NK/T cell lymphoma make their detection very useful and important in diagnosis and differential diagnosis.

The presence of the cervical artery sulcus ring was found on the atlas in 56 out of 346 air pilots. The X ray appearance could be classified as follows. Type Ⅰ:Complete sulcus ring in 32 cases, in whom the sulcus might be complete unilaterally or bilatrally. Type Ⅱ: Incomplete or half ring in 18 cases. This type could be further divided into Ⅱ a , consisting of 4 persons with half ring in the anterior aspect, andⅡ b , half ring posteriorly in14 persons. Type Ⅲ: Broken ring in 6 persons. It is an anatomic variation, which may be have some relationship to vertigo. It is suggested that the presence of cervical artery sulcus ring on atlas should be taken as an disqualification factor in air pilot recruitment.