Purpose To study the clinicopathological features, immunophenotype and differential diagnosis of spindle cell rhabdomyosarcoma in adults (SRMS).Methods The clinical,pathologic and immunohistochemical features were evaluated in 9 cases of SRMS in adults.Results Nine cases of SRMS in adults were retrieved from the pathological archive of this hospital. 7 cases were male and 2 were female. Patients age ranged from 20 to 80 years (median,45 years). The head and neck region,including the right mandible, pharyngeal portion, nasopharynx, and left maxillary,was the most commonly affected area, accounting for 44% of the cases, followed by forearm, waist, thigh, leg and testis(1 case each). Tumor size varied from 2 to 14 cm (median 5.9 cm).Histologically, all the tumors were mainly composed of cellular bands and fascicles of atypical spindlE-shaped tumor cells with a variable number of spindled or polygonal rhabdomyoblasts.In addition, focal areas reminiscent of interstitial sclerosing were presented in 2 cases, and pseudovascular structures were noted in 2 cases, loosely myxoid stroma were detected in 1 case and small solid areas with mild pleomorphic tumor cells were present, but lacking bizarre pleomorphic rhabdomyoblasts. Immunohistochemically, the tumor cells were positive for vimentin, desmin, CD99 and MyoD1; Myogenin and MSA were positive in most of the cases (6/9 and 7/9 each); The remaining antibodies(S-100, CD34,CK and HMB-45) were all negative. Follow-up information was available in all the cases, ranged from 6 months to 4 years, revealed paravenous metastases of the peritoneal cavity in one patient with testis tumor and liver metastases in one patient with leg tumour. 4 patients developed local recurrences and 2 patients died of the disease.Conclusions SRMS is a rare neoplasm in adults,and most commonly occurs in male with preferential involvement in the head and neck region. It appears a more aggressive clinical course in adults. Morphologically, SRMS in adults should be differentiated from other spindle cell tumors.

Vascular endothelial growth factor is a vascular endothelial cell-specific mitogen.It is the most important angiogenic factor.VEGF expresses highly after cerebral infarction.It plays importmt roles in angiogenesis and neuroprotection.At the same time,its overexpression will also increase vascular permeability;thereby it may aggravate brain edema.This article reviews the advances in research on VEGF and its receptors and cerebral infarction.

Objective:To explore the application effect of a home enteral nutrition intervention program based on the "Stimulus-Organism-Response" model in patients with head and neck neoplasms.Methods:Using the convenient sampling method, a total of 84 patients with head and neck neoplasms who were treated in the Oral/Otolaryngology Department of the First Affiliated Hospital of Wenzhou Medical University from January to December 2019 were selected as the research objects. The patients were divided into the control group and the experimental group by random number table method, with 42 cases in each group. The control group received routine enteral nutrition nursing, while the experimental group implemented a home enteral nutrition interventions program based on the "Stimulus-Organism-Response" model. The score of the Home Enteral Nutrition Cognition Questionnaire, nutritional indexes, nutritional status and the score of the Tumor Patient Satisfaction Questionnaire were compared between the two groups.Results:After intervention, the score of Home Enteral Nutrition Cognition Questionnaire, body weight, albumin, prealbumin, transferrin, retinol binding protein, globulin and lymphocyte level of patients in the experimental group were all higher than those of the control group [ (26.04±3.12) vs. (23.76±3.61) , (60.24±5.35) vs. (57.25±5.54) kg, (37.34±3.24) vs. (35.22±3.45) g/L, (0.26±0.04) vs. (0.20±0.05) g/L, (2.62±0.08) vs. (2.37±0.10) g/L, (36.74±7.12) vs. (33.45±6.92) mg/L, (28.87±3.68) vs. (26.67±4.23) g/L, (1.72±0.30) vs. (1.49±0.33) ×10 9/L], and the differences were statistically significant ( P<0.05) . The nutritional status of patients of the two groups after intervention was compared, and the difference was statistically significant ( P<0.05) . After intervention, the scores of health education, nursing skills, condition monitoring and communication dimensions of Tumor Patient Satisfaction Questionnaire in the experimental group were higher than those in the control group [ (4.25±0.65) vs. (3.21±0.78) , (4.15±0.77) vs. (3.76±0.64) , (4.17±0.70) vs. (3.82±0.68) , (4.27±0.54) vs. (3.65±0.82) ], and the differences were statistically significant ( P<0.05) . Conclusions:Application of home enteral nutrition intervention program based on the "Stimulus-Body-Response" model in patients with head and neck neoplasms can improve nutritional awareness, improve nutritional indicators and nutritional status, and increase nursing satisfaction of patients, which is worthy of clinical promotion.

Objective:To study the stability and influencing factors of potassium iodate iodized salt that can be sold in Jilin Province.Methods:In November 2020, 10 large supermarkets were randomly selected in Jilin Province, and two kinds of potassium iodate iodized salts were randomly selected in each supermarket, with five copies of each kind, a total of 100 samples of iodized salt, and the iodine content was determined by spectrophotometry (iodide-starch blue light method). Iodized salt samples were classified according to different salt species (mine salt, sea salt and lake salt) and different production processes (refined salt and non-refined salt). The salt was stored at room temperature, and the iodine content in the salt was measured at 0, 10 and 20 days after opening the packaging. The iodine content attenuation rates of different salt species and different production processes were compared.Results:The mine salt, sea salt and lake salt in iodized salt samples were 45, 45 and 10 portions, respectively. The iodine contents of the 0th day of storage [(19.89 ± 1.38), (20.62 ± 1.91), (19.78 ± 1.01) mg/kg] were compared, and the difference was not statistically significant ( F = 2.57, P = 0.093). On the 10th day, the iodine content of mine salt was lower than that of sea salt and lake salt, and the differences were statistically significant ( P < 0.05); on the 20th day, the iodine content of mine salt was lower than that of sea salt, and the difference was statistically significant ( P < 0.05). There was a significant difference in the iodine content of mine salt stored at 0, 10 and 20 days ( F = 90.62, P < 0.001). The iodine content of sea salt and lake salt on the 20th day was significantly lower than that on the 0th and 10th day, and the differences were statistically significant ( P < 0.05). The iodine content attenuation rates of mine salt, sea salt and lake salt on the 0 - 10 days was compared with that on the 10 - 20 days, and the differences were statistically significant ( Z = 2.24, 2.94, 2.80, P < 0.05). There was a significant difference in the iodine content attenuation rates of mine salt, sea salt and lake salt during the 0 - 10 days of storage ( Z = 24.05, P < 0.001), there was no statistically significant difference in the iodine content attenuation rates on 10 - 20 days ( Z = 5.86, P = 0.053). There was no significant difference in iodine content attenuation rates between refined salt and non-refined salt on 0 - 10, 10 - 20 days ( Z = 1.16, 0.28, P > 0.05). There was no statistical significant difference in the iodine content attenuation rates of refined salt and non-refined salt on the 0 - 10 days compared with those of 10 - 20 days ( Z = 0.76, 1.90, P > 0.05). Conclusions:Iodine loss occurs at 20 days after opening the packaging of iodized salt in Jilin Province. The attenuation of iodine content is less affected by salt species and production processes. It is recommended to eat iodized salt within 20 days after opening the packaging.