Objective To explore the change of ECG after chemotherapy and radiotherapy in treatment of patients with breast cancer. Methods 58 patients with breast cancer were treated with surgery,after operation the observation group were treated with chemotherapy and radiotherapy,and the control group was given chemotherapy singly.The change of ECG was compared between two groups. Results In the observation group,11 patients had abnormal ECG(37.93%),In the control group,2 patients had abnormal ECG(9.52%)(x2=8.03,P ＜0.05＝.In addition,in the observation group the incidence of abnormal ECG in the patients with left breast cancer(7/15)was slightly higher than that with right breast cancer(4/14)(x2=1.01,P ＞ 0.05). Conclusion The treatment of chemotherapy combined with radiation could significantly increase cardiac toxicity in the patients with breast cancer.

This paper presents a method for trace level analysis of microcystins in water using solid-phase extraction and high performance liquid chromatography.The optimized condition enabled the determination of common microcystins at levels as low as 0.02～0.05μg/L,and the liner range is from 0.1μg/L to 50 μg/L. The method has been applied to the analysis of field sample from Dianchi lake.

BACKGROUND:Stent implantation is a common treatment for various cardiovascular diseases. Biodegradable AZ31 magnesium al oy stent is a new kind of biodegradable stent, but its degradation time and effect are stil rarely reported. OBJECTIVE:To investigate the degradation time and effect of AZ31 magnesium al oy stent in the rabbit aorta. METHODS:Twenty New Zealand white rabbits were subjected to implantation of biodegradable AZ31 magnesium al oy stents into the abdominal aorta. After implantation, the animals were grossly observed, and five animals were sacrificed under anesthesia at 1, 2, 3 and 4 months respectively for X-ray and histological observations. The number of residual struts was calculated under microscope. RESULTS AND CONCLUSION:X-ray findings showed that the implanted stent was found to be in complete form at 1 month after implantation, and its degradation was elicited at 2 months, indicating the stent lost its supporting role gradual y. The stent was degraded mostly at 3 months and degraded completely at 4 months. After implantation, the degradation rate of the stent was increased over time, which was confirmed by the X-ray findings. The number of residual struts was correlated with the time of degradation (r=-0.943, P<0.05). The slope of the linear regression equation was-0.12, based on which, the total time of the stent degradation was calculated to be 105 days. These results show that the AZ31 magnesium al oy stent implanted in the rabbit aorta is gradual y degraded with time, and the number of its residual struts exhibits an association with the degradation time. Given that the average number of degraded struts per day is 0.12, the complete stent is expected to be degraded within 105 days after implantation.

Pathologist Dixit in American Michigan University found a gene induced by cytokine from human umbilical vein endothelial cells in 1990.This gene is increased in a variety of cells rapidly and coded a special kind of the zinc finger protein when being stimulated by interleukin-1 (IL-1),PLS and tumor necrosis factor (TNF).The gene was named as zinc finger protein A20 gene,and its coding protein was named as zinc finger protein A20.A20 is a kind of endogenous regulatory protein,inhibiting the inflammatory reaction and cell apoptosis through the inhibition of NF-kappa B activity.This article mainly reviewed the structure,function and clinical significance of A20.

Objective To observe the displacement of endotracheal tube during laparoscopic surgery,explore whether pneumoperitoneum and body position are associate with the displacement. Methods A total of 120 female patients were included in this study,60 cases underwent gynecological lapa-roseopic operation as group A,and 60 cases had laparoscopic cholecystectomy as group B.Intrabdominal pressure was maintained in 13 mm Hg during the operation.The length of trachea(Lac),the length from carina to the tip of an endotracheal tube(Lab),the length from glottis to the tip of an endotracheal tube (Lbc)and the cuff pressure (Pc)were measured after endotracheal intubation (T1 ),insufflation in the su-pine position (T2 ),insufflation in the Trendelenburg or reverse Trendelenburg position (T3 ),30 minutes after insufflation in the Trendelenburg or reverse Trendelenburg position (T4 ),deflation in the Trendelen-burg or reverse Trendelenburg position (T5 ),deflation in the supine position (T6 ).Results In both groups,Lac and Lab at T2-T4 were significantly shorter than those at T1 (P<0.05),but they were back to the original level at T5 ,T6 .Pc were higher at T2-T4 (P<0.05).Lac,Lab and Lbc didn’t show significant difference between the two groups at T1-T6 .At T2 and T3 ,in group B endotracheal tube distorting occurred in 2 patients and tube into right bronchus occurred in 3 patients,while tube into right bronchus occurred in 3 patients in group A.Conclusion Pneumoperitoneum can cause endotracheal tube displacement to-ward to carina.Body position unlikely to change endotracheal tube position.The displacement was blocking by cuff could cause distorting of the tube.

Objective: To study the influencing factors of the rural medical service demand. Methods: The gravity model of medical service demand was derived based on Individual utility function and profit objective function of medical institutions, and the data regression examine model of some county-level and district-level hospital were used. Results: According to the research, the main factors influenced the quantity of medical services come from medical supplies. With the increase of resident disposable income, the elasticity of demand for medical services decreased, while visiting distance of elasticity of demand for medical services increased. Conclusion: To increase the accessibility of medical service, it needs to set meeting the resident’s personal demand as the center, to promote the development of private hospitals. The scale of large hospitals should be limited so as to lead large-scale hospitals to separate low value-added medical services and to promote effective implementation of the treatment classification system.

Designed experiment can improve the students'study interest and train their scientific research ability in bioanalytical chemistry experiment teaching.This article probes into the devise of designed experiment,the selectivity of the contents and the detailed process of the experiments.

Objective To observe the clinical efficacy of Xuebijing injection ( XI) for the treatment of septic myocardial injury, and to study the possible therapeutic mechanism. Methods Thirty-nine qualified septic myocardial injury patients were randomly divided into XI group (N=24) and control group (N=15) . Both groups were treated with conventional therapy, including anti-inflammation treatment, transfusion for resuscitation, nutritional support, symptomatic and supportive treatment, and supportive treatment for keeping vital organ function. XI group was given intravenous drip of XI based on the conventional therapy. Before and after treatment, the peripheral blood concentrations of myocardial-specific isoenzyme of creatine kinase (CK-MB), cardiac troponin I (cTnI), brain natriuretic peptide ( BNP) and plasma calcitonin ( PCT) were detected, and the changes of electro-cardiogram ( ECG) were also observed. The mortality within 28 days was compared between XI group and the control group. Results ( 1) After treatment, cTnI, BNP and PCT concentrations in XI group were decreased significantly as compared with the control group, and there was statistical significance (P <0.05) . However, the decrease of CK-MB was not obvious in XI group ( P>0.05 compared with the control group) . ( 2) The difference of ECG was insignificant between the two groups after treatment ( P>0.05) . ( 3) The 28-day mortality was 8.33% in XI group, and was 13.33% in the control group, the difference being insignificant between the two groups (P>0.05) . (4) During the treatment, none case had adverse reaction. Conclusion XI can improve the myocardial injury, and relieve inflammation of septic myocardial injury patients.

The deterioration of indoor air quality (IAQ) in medical district was caused by the personnel in the area, the buildings and their surroundings, and the situations of the air conditioning system. It is necessary to control the personnel entering the medical area and to strengthen the management of the buildings and their surroundings, and the air conditioning system for maintaining high IAQ. The development of new efficient air cleaning (equipment) is of importance in the same way.

OBJECTIVE:To study the influence of different doses of naloxone on focal cerebral ischemia reperfusion injury in rats and to explore its mechanism.METHODS:The rats were randomly divided into the sham operation group,the model group,the naloxone group(high dosage,moderate dosage,and low dosage)and the positive control group.The modified Longa method was applied to establish the models of focal cerebral ischemia reperfusion in rats.Infarct size,neurological deficit scores,superoxide dismutase(SOD)activity,malondialdehyde(MDA)content in serum of the model rats were detected.The ultrastructures of the brain tissues were observed by electron microscopy.RESULTS:Ischemia reperfusion injury in model rats resulted in increased neurological deficit scores,larger infarct size,decreased activity of SOD in serum and increased content of MDA.The pathological change and ultrastructural change were evident.The above indices were improved in all the groups administered with different doses of naloxone.CONCLUSIONS:Naloxone has protective effects on rat brain injury caused by focal cerebral ischemia reperfusion,whose mechanism might be related to inhibition of lipid peroxidation.