The 15th World Conference on Lung Cancer (WCLC) received about 210 abstracts on radiotherapy.These abstracts covered many realms,including the efficacy,safety,evaluation methods and dose fractionation study of stereotactic body radiotherapy (SBRT) on early stage non-small-cell lung cancer (NSCLC); control studies of high and standard radiation dose,different chemotherapy regimens and whether combined cetuximab in concurrent radiochemotherapy on locally advanced NSCLC clinical significance of postoperative 3D-conformal radiotherapy (3D-CRT) for patients with p Ⅲ A-N2 NSCLC after complete resection; the efficacy and safety of TKIs in combination with whole brain radiation therapy (WBRT) in NSCLC patients with multiple brain metastases,as well as the influence of EGFR mutation status on the curative effect.Besides,there are many reports about radiotherapy protection,toxicity,efficacy,prognosis and life quality assessment.

Therapies targeting endocrine receptors and human epidermal growth factor receptor 2 have become important treat-ment modes for patients with hormone receptor breast cancer. Despite the availability of these options, however, development of prima-ry or secondary drug resistance and subsequent disease progression in patients with advanced disease continue to occur. Mammalian tar-get of rapamycin (mTOR), a key regulator of cell growth and proliferation, has been implicated in the induction of cellular processes leading to the uncontrolled growth of cancer cells. Recent studies have suggested that overactivation of the mTOR pathway may be in-volved in the development of endocrine resistance. Interrupting this signaling cascade may alleviate such resistance and help restore drug sensitivity. A number of agents targeting the mTOR pathway have shown potent anti-tumorigenic effects in vitro, and several agents show great potential for treating breast cancer patients. Many clinical studies have shown that combining endocrine therapy with mTOR inhibitors could significantly increase the survival rate of breast cancer patients. In this study, we focus on recent research prog-ress on mTOR and its inhibitors in endocrine therapy resistance in breast cancer.

MicroRNAs (miRNAs) negatively mediate the post transcriptional target genes by degrading mRNAs and inhibiting translation of protein.Deregulation of miRNAs are directly or indirectly correlated with tumorigenesis and development of cancer.Currently,the application of miRNAs as a non-invasive potential biomarker with high stability is under investigation.

Objective To investigate the correlation between b value and image quality of diffusion weighted imaging(DWI).Methods DWI was performed in 20 healthy volunteers and 60 patients with liver lesions.Signal to noise ratio ( SNR ) and contrast to noise ratio ( CNR ) were calculated . Results The mean SNR was larger than 5 when b value was 100 s/mm2 or 300 s/mm2, while b value was 600 s/mm2 or 1100 s/mm2, SNR was less than 5. With b value increased, the influence of blood supply on ADC decreased, but the artifacts increased and CNR decreased, CNR of cystic lesions decrease more than that of solid lesions.Conclusion The gradient factor(b)between 300 s/mm2 and 600 s/mm2 is the most suitable in DWI.

OBJECTIVE:To study the influence of different doses of naloxone on focal cerebral ischemia reperfusion injury in rats and to explore its mechanism.METHODS:The rats were randomly divided into the sham operation group,the model group,the naloxone group(high dosage,moderate dosage,and low dosage)and the positive control group.The modified Longa method was applied to establish the models of focal cerebral ischemia reperfusion in rats.Infarct size,neurological deficit scores,superoxide dismutase(SOD)activity,malondialdehyde(MDA)content in serum of the model rats were detected.The ultrastructures of the brain tissues were observed by electron microscopy.RESULTS:Ischemia reperfusion injury in model rats resulted in increased neurological deficit scores,larger infarct size,decreased activity of SOD in serum and increased content of MDA.The pathological change and ultrastructural change were evident.The above indices were improved in all the groups administered with different doses of naloxone.CONCLUSIONS:Naloxone has protective effects on rat brain injury caused by focal cerebral ischemia reperfusion,whose mechanism might be related to inhibition of lipid peroxidation.

Objective To investigate the role of survivin gene in the pathogenesis of endometriosis (EMs). Methods The expressions of survivin in endometriosis and normal endometrium tissue were determined ; the effects of GnRHa and COX-2 on the expression of survivin mRNA in endometriosis and normal endometrium in vitro and the effects of GnRHa and COX-2 on the apoptosis index in the cultured ectopie endometrial cells were investigated. Re-sults ①The expression of survivin mRNA was higher in patients with endometriosis than that of healthy controls (P <0.01) ,with no cyclical variation. ②GnBHa exerted a dose-dependent suppression of survivin mRNA expres-sion in cultured ectopic endometrioma cells as well as COX-2. The significant suppression was observed at the 100μg/L concentration of GnRHa and at the 40 μmol/L concentration of COX-2. No cooperation was found between them (P > 0.05). Conclusion ①The up-regulation of survivin mRNA expression may reduce the sensitivity of en-dometriotic cells to apeptosis. Elevated expression of survivin mRNA in ectopic endometrium may have important im-plications for the survival and proliferation of the ectopic endometrial tissue.②Both GnRHa and COX-2 can promote apoptosis by inhibiting survivin mRNA expression in ectopic endometrioma cells in vitro.

Objective:To explore the role of IL-21 in regulating the expression of peripheral blood Treg cells in the pathogenesis of Graves disease ( GD ) . Methods: Electrochemical luminescence detection was used to determine levels of thyroid function indexes and autoantibodies. Peripheral blood mononuclear cells (PBMCs) were extracted,then,cultured in the presence or absence of IL-21 in vitro. The level of IL-10 protein was measured by enzyme-linked immunosorbent assay ( ELISA) ,and expressions of Foxp3 and IL-10 mRNA were examined by Real-time PCR. Results: Compared to eGD and control group, there were significant differences in the levels of thyroid function indexes in GD group (P<0. 05),whereas there was no difference between control group and eGD group (P>0. 05). Before IL-21 stimulation,compared to eGD and control groups,expressions of Foxp3 and IL-10 mRNA and level of IL-10 protein were significantly higher in GD group ( P<0. 05 );but there were no significant differences between eGD group and control group (P>0. 05). After IL-21 stimulation,expressions of Foxp3,IL-10 mRNA and IL-10 protein levels were decreased markedly in all three groups,among which GD group showed the greatest change(P<0. 05). Conclusion:IL-21 may inhibit the differentiation of Treg cells and the production of IL-10,therefore decreasing the number of Treg cells and the ability of suppressing effector T cells ,thus should be involved in the pathogenesis of GD.

The morbidity of young non-small cell lung cancer(NSCLC)increases in the recent years.Young group patients should be defined as age under 40 years old.The risk factors of etiology in the young NSCLC may be related with smoking,genetic predisposition,Internal and external environment factors havoc and etc.There is no specific symptoms of young NSCLC,therefor,it happens misdiagnosis and harder to be confirmed.The morbidity in young female group of NSCLC patients is higher than aged patients.The most frequent histopathologic type is adenocarcinoma and the ratio of advanced stages with low differentiation has been found to be more common.The chances of surgery seems lower than others.EGFR gene mutation percentage in the young NSCLC maybe lower than that in the old patients,while the positive mutation of MEL4-ALK gene maybe more prevalent in the young patients.The prognosis of young NSCLC seems to be poor with lower tumor progression time of the first line therapy.Better prognosis of young NSCLC patients maybe achieved by early diagnosis and efficient therapy according to the accurate genotypes.

Matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) is a kind of the latest mass spectrometry,which has many advantages including high throughput,rapidity,excellent repeatability and high sensitivity.It has been an important tool for both the research and clinical application in lung cancer and has an optimistic prospect in the many fields,such as early diagnosis,screening and evaluation of therapeutic effect.

We collected the clinical information of 21 in-patients diagnosed as Lyme disease in Peking Union College Univemity Hospital from Apr. 1994 to Jan. 2008. The clinical manifestations, laboratory tests, therapy and prognosis were analyzed retrospectively. 16 of 21 (76%) patients had fever, 14 of 21 (67%) eases had skin lesion, 17 patients had nervous symptoms, 10 cases showed arthrosis and only 2 of 21 eases involved in heart. The antibiotics of penieilin,ceftriaxone and doxyeycline were used for therapy. All of the 21 patients improved clinically and discharged. 12 cases were followed up for 1 month to 12 years and 2 of them relapsed, both of whom were in Stage Ⅲ. 8 cases remained persistent symptoms. As the manifestations of Lyme disease are complicated, for clinical borderline cases the prompt detection of etiological agent may be useful for early diagnosis. The antibiotic therapy should begin as early as possible to avoid developing chronic Lyme disease.