Objective:To retrospectively study the effect and curative effectiveness of ethanol in treating HCC with portal vein tumor thrombus(PVVT) through transcatheter fed arterial super selective infusion and super selective arterial embolization of main tumor,appraise the effect of ethanol in local treatment,in order to improve the clinical curative effects on the patients. Methods:The data of study from 86 cases of HCC with PVVT in our hospital between 2001~2004 year,to the fed artery of portal vein tumor thrombus super selective infusion ethanol or ethanol and gelfoam or ethanol and lipiodol,also through transcatheter super selective embolizing the fed arterys of main tumors including TACE or ethanol and lipiodol in 86 cases HCC. The course of observation was between 2001 and 2007year. Results:The super selective fed arterial embolization of PVVT and main tumors were successful in all cases;After treatment,ascites disappeared or obviously reduced in 66.3%(57/86) of cases,reduce in 23.2%(20/86),did not reduce in 10.5%(9/86);After 7~10d,hepatic function obviously improve or improve in 71%(61/86),did not obviously change in 11.6%(10/86),lowered in 6%(5/86),with no obvious lowering of hepatic function or hepatic function failure.The survival rates at 3,6,12,24,36months were 97.7%(84/86),95.5%(82/86),72.7%(62/86),47.7%(41/86) and 16.3%(14/86) respectively. Conclusion:The therapy of ethanol through catheter super selective PVVT fed arterial infusion is safe and effective,combined with super selective TAE or TACE to the fed artery of main tumor,could obviously improve the quality of life of the patients and could improve the survival rate.

Objective:To retrospectively evaluate the safety,technical success rate,and effectiveness of ultratranscatheter tumor feeding arterial embolization with ethanol and lipidol for SHCC,and to explore the new therapy for SHCC. Methods:To 95 cases carry out hepatic selective arterial angiography for SHCC by CT or MRI be diagnosed and clinical very doubt be SHCC,after was diagnosed by DSA,to transcatheter ultraselective subsegmental feeding artery with microcatheter for tumor,employ ethanol and lipidol (1/1) to full fill embolized 143 tumors. Results:Technical success rate was 100% for the ultraselective subsegmental feeding artery transcatheter and embolizatoin in SHCC,There were no major complications in all cases.Before embolization ,the diameter of tumors were 0.5~3cm,average diameter 2.3 cm. after tumors were embolized,average diameter 1.2 cm. The 1,3and 5 year recurrence rates were 19%(18/95),27%(26/95),37%(35/95),and the survival rates were 100%(95/95),85%(81/95),67%(64/95) respectively. Conclusion:Its effectiveness was very notable,there were no major complications and recurrence rates was less than surgical resection in ultraselective transcatheter tumor feeding arterial embolization with ethanol and lipidol for SHCC,It should become the first selective therapy for SHCC.

Objective:To evaluate the safety,technical success rate,and effectiveness of transcatheter superselective arterial chemoembolization(TACE)for unresectable lung cancer and the metastases tumor with rich blood feeding in lung.Methods:Using Japan Shimadzu 1250Ma CCD DSA X machine,4F RH or 4F YASHIRO catheter and 3F SP microcatheter were employed in superselective chemoembolization for feeding artery of lung cancer and the metastases tumor with rich blood feeding in lung with lipiodol and 2～3 species chemodrug.The period of repetitive treatment was 4～6weeks.After treatment,the change of the symptoms,images of neoplasm and the survival rates were observed.Results:Transcatheterization and embolization were successfully completed in 88 out of 90 cases.Technical success rate was 97.8% without spinal damage occuring.After 2～3 time treatment,the symptoms of the patients obviously improved in 87cases(96.7%);neoplasm notable shrank in 82 cases(91.1%),partly shrank in 5 cases(6%),not shrinking in 3 cases(3.3%).The survival rate respectively at 6 months,12 months,24 months,36 months were 98.8%(89/90),93.3%(84/90),83.3%(75/90)and 53.3%(48/90).Conclusions:The technical success rate at Superselective transcatheter arterial chemoembolization for feeding artery of the neoplasm that rich blood fed in lung is high.Complications rate is lower.Its effectiveness is more notable than bronchial artery chemodrug infusion.

China ; Forecasting ; Gaucher Disease ; diagnosis ; therapy ; Humans ; Rare Diseases

Syncope is a common pediatric emergency event,which can be caused by various metabolic disorders different from other illness. The major metabolic anomalies include hypoglycemia, hyperventilation,electrolytes imbalance,hypoxemia and others, in which hypoglycemia is caused by hyperinsulinemia,pituitary and adrenal disease, diabetes, ketotic hypoglycemia, inherited metabolic disorders of sugar, organic acids and amino-acids,etc. This article introduced the common metabolic anomalies and their causes,diagnosis and therapy.

To examine the role of glycogen synthase kinase 3 (GSK-3) in the apoptosis of pancreatic beta-cells to better understand the pathogenesis and to find new approach to the treatment of type 2 diabetes, apoptosis was induced by oleic acid (OA) in INS-1 cells and the activity of GSK-3 was inhibited by LiCl. The PI staining and flow cytometry were employed for the evaluation of apoptosis. The phosphorylation level of GSK-3 was detected by Western blotting. The results showed that OA at 0.4 mmol/L could cause conspicuous apoptosis of INS-1 cells and the activity of GSK-3 was significantly increased. After the treatment with 24 mmol/L of LiCl, a inhibitor of GSK-3, the OA-induced apoptosis of INS-1 cells was lessened and the phosphorylation of GSK-3 was increased remarkably. It is concluded that GSK-3 activation plays an important role in OA-induced apoptosis in pancreatic beta-cells and inhibition of the GSK-3 activity can effectively protect INS-1 cells from the OA-induced apoptosis. Our study provides a new experimental basis and target for the clinical treatment of type-2 diabetes.
Apoptosis/*drug effects ; Cell Line ; Fatty Acids, Nonesterified/*pharmacology ; Glycogen Synthase Kinase 3/*metabolism ; Insulin-Secreting Cells/*cytology ; Oleic Acid/pharmacology ; Phosphorylation

The surface of pure titanium consequently covered by a stable oxide layer at room temperature, due to its highly reactivity, the oxide layer easily develops into thick contaminated layer at high temperture, that further effects the bond strength between titanium and porcelain. Therefore, surface treatment on pure titanium is very important. This article reviews the methods of surface treatment on pure titanium and the effect on the bond strength and the color of porcelain.

Objective To study the result of DSA for 56 cases with large liver cancer that there is bloody supply from arteria musculophrenica right and the clinical value of super selective interventional embolization,so that to improve the clinical curative effects of interventional therapy. Methods Employ 4F, 3F catheter super selectively into arteria musculophrenica that supply blood to cancer. Result 56 cases(21.7% )were discoverod that there was bloody supply from arteria musculphrenica right to cancer in 258 cases with large liver cancer, liver neoplastic size of all cases wasin 5～15cm,22 cases(8.6% ) were discovered in the first interventional operation,34 cases ( 13.3% )were discovered in the second or the third interventional operation. Obvious tumor shrinking in all cases: the 6month survival as 56 cases(100 % ), the 1-year survival as 45 cases (80.4%), the 2-year survival as 21 cases(37.5%). Conchssion Arteria musculophrenica right supply blood to cancer is common in large liver cancer eases, super selectively embolized the supply blood from the arteria musculophrenica right is very important for acquiring success by interventional operation.

Objective To investigate the effects of Atrovent aerosol inhalation in the treatment of respiratory failure and nursing intervention of chronic obstructive pulmonary disease effect. Methods January 2016 to December 2016 in Huzhou Central Hospital for diagnosis and treatment of chronic obstructive pulmonary disease patients with respiratory failure in 50 cases dewided into control group and observationgroup: the control group treated with conventional methods, the observation group treated with Atrovent aerosol inhalation therapy and conventional methods; the patients in the two groups of experimental data were recorded in detail, and the obtained data were analyzed. Results The observation group was better than that of treatment and intervention control group, clinical symptoms improved better than the control group, the adverse reaction rate were lower than the control group, there is significant statistical difference (P<0.05). Conclusion The patients with chronic obstructive pulmonary disease with respiratory failure choose conventional and Atrovent aerosol inhalation treatment effect significantly, can effectively improve the patient clinical symptoms and adverse reactions are few and deserve to be widely used in the treatment of chronic obstructive pulmonary diseaseand respiratory failure patients.

All-ceramic dental materials could meet the requirements for extraordinary aesthetics and ex-cellent biocompatibility in vivo, thus are widely utilized in prosthetic dentistry. Since the all-ceramic materials have low strength reliability and the disadvantage is recently concerned, the relevant research has been the focus in the area. The purpose of this artical is to review the relevant studies and with focus on the factors that influence the strength including material component, microstructures and manufacture process, as well as strength improv-ing approaches such as ingredient alteration, fabrication optimization and surface treatment. As for various strength testing methods, all the existing test methods are compared and evaluated.