Objective To assess the effect of parent-child individual management in children with mycoplasma pneumonia and to provide guidance for improve the quality.Methods 482 children with mycoplasma pneumonia were divided into parent-child individual management group and conventional intervention group according to the time including the study.The parent-child individual management group used specially formulated for the mother and child management intervention + conventional measures.The conventional intervention group used conventional nursing neasures.The duration of hospitalization,hospitalization expense,depression,family members of patients satisfaction,curative effect,clinical index were compared between the two groups.Results Mter intervention,compared with the conventional intervention group,the duration of hospitalization,hospitalization expense decreased lower [length of stay:(12.08 ± 1.26) d vs.(15.82 ± 3.07) d,t =16.398,P =0.000;hospitalization expense:(641.57 ± 124.28) RM B vs.(896.72 ± 179.15) RM B,t =17.012,P =0.000],the maternal anxiety of the parent child individual management group reduced obviously [anxiety scores (34.21 ± 4.51) points vs.(43.29 ± 6.17) points,t =17.245,P =0.000] and the satisfaction of children of the parent-child individual management group improved obviously(most satisfaction rate:65.71％ vs.49.52％,x2 =10.663,P =0.001;satisfaction rate:27.14％ vs.29.25％,x2 =0.928,P =0.710;general satisfaction rate:5.71％ vs.16.04％,x2 =10.538,P =0.000;dissatisfaction:1.43％ vs.5.19％,x2 =3.552,P =0.060;total rate:92.86％ vs.78.77％,x2 =16.021,P =0.000).The efficacy of the parent-child individual management group improved obviously (inefficiency:7.14％ vs.21.22％,x2 =16.021,P =0.000;efficiency:17.19％ vs.21.21％,x2 =1.812,P =0.178;cure rate:73.33％ vs.53.30％,x2 =17.364,P =0.000;total effective rate:92.85％ vs.78.77％,x2 =16.021,P =0.000).The clinical indicators of the parent-child individual management group were improved obviously[pyretolysis days:(3.42 ± 1.46) d vs.(4.56 ±1.67) d,t =7.463,P =0.000;cough disappeared days:(8.72 ± 2.04) d vs.(10.29 ± 1.95) d,t =8.030,P =0.000;rales disappeared days:(3.96 ± 1.45) d vs.(5.87 ± 1.7 1) d,t =12.370,P =0.000].Conclusion The parent-child individual management in children with mycoplasma pneumonia has good effect on the hospitalization days,hospitalization expense,the satisfaction of children,the curative effect and the clinical indicators,it is worthy of clinical promotion.

OBJECTIVE: To explore the genetic basis for a juvenile with maturity-onset diabetes of the young type 12(MODY12). METHODS: High-throughput sequencing was carried out to screen for the variants. Candidate variant was verified by Sanger sequencing. Pathogenity of the variant was predicted by searching the genetic databases and analysis by using bioinformatic software. RESULTS: Genetic testing indicated that the patient and his mother have both carried a heterozygous c.3976G>A variant (p.Glu1326Lys) in exon 32 of the ABCC8 gene. Prediction of the protein structure suggested the variant to be deleterious. Based on the guidelines of the American College of Medical Genetics and Genomics, the variant was predicted to be uncertain significance. CONCLUSION Whether the c.3976G>A variant of the ABCC8 gene is the cause of the disease in this patient or not depends on the functional studies and more case data. Above finding has enriched the spectrum of ABCC8 gene variants.
Diabetes Mellitus, Type 2/genetics* ; Genetic Testing ; Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; Mutation

Traumatic cerebrospinal fluid leakage commonly presents in traumatic brain injury patients, and it may lead to complications such as meningitis, ventriculitis, brain abscess, subdural hematoma or tension pneumocephalus. When misdiagnosed or inappropriately treated, traumatic cerebrospinal fluid leakage may result in severe complications and may be life-threatening. Some traumatic cerebrospinal fluid leakage has concealed manifestations and is prone to misdiagnosis. Due to different sites and mechanisms of trauma and degree of cerebrospinal fluid leak, treatments for traumatic cerebrospinal fluid leakage varies greatly. Hence, the Craniocerebral Trauma Professional Group of Neurosurgery Branch of Chinese Medical Association and the Neurological Injury Professional Group of Trauma Branch of Chinese Medical Association organized relevant experts to formulate the " Chinese expert consensus on the diagnosis and treatment of traumatic cerebrospinal fluid leakage in adults ( version 2023)" based on existing clinical evidence and experience. The consensus consisted of 16 recommendations, covering the leakage diagnosis, localization, treatments, and intracranial infection prevention, so as to standardize the diagnosis and treatment of traumatic cerebrospinal fluid leakage and improve the overall prognosis of the patients.