Objective To investigate the expression of extracellular matrix metalloproteinase inducer CD147 in patients with bladder urothelial carcinoma and its relationship with clinicopathologic features and prognosis.Methods RT-PCR and Western blot were used to evaluate the mRNA and protein expression of CD147 in cancer tissues and corresponding paracanerous tissues from 20 patients with bladder urothelial carcinoma;tissue microarray containing specimens from 108 patients with bladder urothelial carcino-ma and 20 normal controls was constructed and immunohistochemistry was applied to examine the expression of CD147,and the correlations between CD147 and clinicopathological characteristics and prognosis were also analyzed.Results Expression level of CD147 mRNA and protein in cancer tissues from 20 bladder urothelial carcinoma patients was significantly higher than that of cor-responding adjacent tissues(P<0.01).Immunohistochemical detection showed normal bladder urothelium from 20 control cases were either no or weak protein expression of CD147,positive expression rate of CD147 in 108 cases of bladder urothelial carcinoma was 73.1%.the CD147 expression level had positive correlation with lymph nodes metastasis,histological grade,tumor stage and tumor size of patients with bladder urothelial carcinoma(P<0.05)and had no relationship with age,sex,the number of tumor(P>0.05).Kaplan-Meier survival curves analysis showed that the survival time of patients with bladder urothelial carcinoma whose ex-pression of CD147 were high was significant lower than that of patients with bladder urothelial carcinoma whose expression of CD147 were low(P<0.01).Univariate analysis showed that histological grade,tumor stage,lymph node metastasis,tumor size and CD147 expression were all positively correlated with a poor prognosis(P<0.05).Cox-multivariate analysis revealed that histologi-cal grade,tumor stage,lymph node metastasis,and CD147 expression level were independent predictors of an unfavorable prognosis (P<0.05).Conclusion High expression of CD147 in bladder urothelial carcinoma may be correlate with the its progress and its expression state is an independent prognosis factor.

The characteristics of C8051F340 MCU and USB communication, and the design method of system's hardware and software structure are introduced briefly. The whole system is proved stable and reliable by experiment. The Universal Serial Bus (USB) communication technology has great value in course of system design and study.

The suceptibilities of ascitic S180 cells to NK cell-mediated binding and killing during their development in vivo were studied at a single cell level, usingsingle cell cytotoxic and binding assaies. The results showed that the NK binding and killing suceptibilities of ascitic S180 cells changed sequentialy during their growth in vivo, the kinetics of which had an appearence of reversed S with both NK binding and killingsuceptibilities being the highest at the fifth day and the lowest at the second day and the tenth day after inoculation of the tumors. However, the changes were seen to be similar when the tumors were inoculated in either adult(6-7-week-old) or yaung(3-week-old) mice, or in different strains of adult mice. Analysis at a single cell level revealed that the change in the NK suceptibilitg of the tumor cells at different growth stages were concomitant with the changes in the number of the tumor target cells capable of being bound by NK cells as shown with an NK-target binding assay, which was consistant to the flactuation of the capability on which the tumor target cells could bind more than one NK cell. Our results indicate the NK-suceptibility of ascitic S180 cells changes uring their growth in vivo, due to the changes of the ratio of NK-suceptible and-nonsuceptible target cells in the tumor cells at different growth stages. The possible cause(s) for the changes is discussed here.

Objective To study the curative effect of luterinizi releasing hormone anogist(LRH-A) with Zhibaidihuang pill treatment for girls idiopathic true precocious puberty(ICPP).Methods 29 girls with ICPP,the breast in 3rd period were selected.9 of them were treated with LRH-A,12 of them were treated with LRH-A and Zhibaidihuang pill,8 of them as comparison group were no-treated.The growth speed,secondary sexual characteristics,bone age,LHRH inspire experiment,ultrasonic measurement of uterus volume and ovarian follicle size and forecast target of height were separately tested before and after treatment.Results Two groups after 4 period of treatment were compared:one group after only treated with LRH-A,the average growth speed was lower;The predict final target of height was not obviously increased;The secondary sexual characteristic reduced;The blood lever of E2,FSH and LH differ decreased;The bone age had no change.The other group after bio-treated with LRH-A and Zhibaidihuang pill,the average growth speed was slow down(P

Co-citation analysis, co-word analysis and strategic coordinates are combined to make known the subject theme evolu-tion. The research history of general surgery is described by eo-citation eluster analysis, citation strategic diagram is pictured by the theory of strategy coordinates to learn more about the novelty and attention of each hot topic. The present research focused on general surgery that would be found by co-words cluster analysis, and stages of development about each topic are discussed by strategic coordinates based of cluster results. It is helpful to provide a decision-making reference for professionals and managers.

The Milestones has become an important component of Graduate Medical Education (GME) of the United States, and the Milestones Guidebook (2016) can help understand and implement the Milestones and improve graduate medical education and practice.This article outlines the basic principles of the Competency-Based Medical Education (CBME) and the Milestones, introduces the guidelines and responsibilities of related stakeholders in Implementing and Using Milestones Effectively, and highlights the Importance of Assessment and Feedback.The Milestones includes 6 core competencies to be achieved in skills, knowledge, and behaviors, its formative process, the causes of its development, and its effective implement and application.The Milestones is the development of CBME and designed to help all practitioners make highly competent physicians.The primary objective of this program is to cultivate trustworthy medical graduates and provide high-quality health care to the general public.

This paper introduces the so ftware development method of the driver for the auto-weatherstation under the s ituation of configuration software,which is to realize the data collection.The m ethod has a bright future in the market and its application.

The authors stated post-operative adjuvant therapy, combined chemotherapy, and palliative treatment for colorectal cancer, trying to summarize progress of the treatment of colorectal cancer with integrated traditional Chinese and western medicine, researching the mechanism of action. The authors also presented their arguments.

Objective Based on scientific research grants to explore the feasibility of analyzing the subiect's hot topics. Methotis The CRISP(Computer Retrieval of Information on Scientific Projects)database of National Institutes of Health was used to retrieve the grants related of gene mechanism of essential hypertension in 2006. We obtained concepts from the fields of title and abstract by MetaMap. and then analyzed the key concepts about genes that were found more than 3 times. Results There were 73 related grants about that from CRISP in 2006. After processing the samples by MetaMap, we got 45 high frequency concepts about genes. which were divided into seven groups. Conclusions It iS feasible to analyze and study subject hotspot by scientific research grants. and it can be used to the supplement of normal literature analysis. MetaMap is a better tool for natural language processing, but also has some limitations.