1.The working principle and application of SK-600I infusion pump
China Medical Equipment 2013;(9):42-44,45
Objective: The theory and repair summary of infusion pump were introduced to improve its maintenance and usage by taking SK-600I infusion pump as an example. Methods:With the cases from practical works including faults such as under-pressure alarm, bubble alarm, block alarms and rate accuracy problem, true or fault respectively, the principle, maintenance, attention issues, fault analyses and repairing methods of infusion pump were presented. Results:To help operators and technicians deal with all kinds of pump failures. Some advices on improving theSK-600I infusion pump design were provided. Conclusion: Infusion pump is a high intelligent medical device, but improper use, mechanical and electrical fault will put adverse impact on its application. Mastering the basic principles, summarizing practical experiences, strengthen operator training, can make better use of infusion pump.
2.THE EFFECT OF GnRH-A ON THE FUNCTION OF SOMATOSTATIN CELLS IN STOMACH AND DUODENUM OF RATS
Xiaoning LIU ; Weiquan HUANG ; Bin GAO
Acta Anatomica Sinica 1955;0(03):-
Objective To investigate the effect of GnRH-A in gastric cavity on the function of somatostatin cells in the digestive tract of rats. Methods The immunohistochemical ABC method and enzyme-link immunoassay were used in the experiment. Results The densities of the somatostatin positive cells in the stomach and duodenum of the experiment groups were 26^6?3^893 and 51^7?2^214 respectively,and significantly lower than those in stomach 48^3?6^019 and duodenum 58^5?4^454 of control groups respectively(P
3.The predictive value of basic lung function and dosimetric parameters of acute radiation pneumonitis during the treatment of concurrent chemoradiotherapy
Lan WANG ; Dongjie Lü ; Chun HAN ; Xiaoning LI ; Chao GAO
Chinese Journal of Radiation Oncology 2011;20(1):40-44
Objective To observe the incidence of RP in NSCLC and esophageal carcinoma treated with 3DCRT and investigate the relationship between acute RP and lung function and dosimetric parameters.Methods From October 2006 to August 2008, 3DCRT plus concurrent chemotherapy of NP or LFP were applied to 64 patients with locally advanced NSCLC or esophageal carcinoma. twenty-three patients suffered form NSCLC and 41 patients from esophageal carcinoma, the prescription doses were 60 Gy/30fx and 58 -64 Gy/29 -32fx, respectively. Results For patients with esophageal carcinoma, 34% developed RP(9 grade 1,3 grade 2 and 2 grade 3). For patients with NSCLC, 96% developed RP(9 grade 1, 8 grade 2 and 5 grade 3). There was significant difference between the two groups(t =5. 55,P=0. 000). The FEV1.0/FVC and DLCO of patients with NSCLC were significantly lower than those of esophageal carcinoma, the ratio were 75.6%:82.7%(t=2.75,P=0.008)and 71.7%:81.0%(t=2.50, P=0.015),respectively. For patients whose FEV1.0, FEV1.0/FVC%, DLCO <80% and ≥80% before irradiation,the incidence of ≥2grade ARP were 35% vs 25% ,31% vs 26% and 35% vs 19%, respectively(x2 = 1.81,0.15,2. 13,P =0.179,0.697,0.144). While for patients whose FEV1.0 < 70% and ≥70%, the incidence of severe ARP were 67% and 22% ,respectively(x2 =5.64, P =0.018). Spearman correlated analysis indicated that all the dosimetric parameters had relation with ≥ 2 grade ARP . The V20 of lung and MLD were found independently associated with RP according to multivariate analysis(x2 = 4.61,6.97, P = 0.032,0.008).Conclusions Parameters of basic lung function can predict the incidence of ≥2 grade RP to some extent,especially when the value of FEV1.0, FEV1.0/FVC%, and DLCO was lower. However, the V20 of lung and MLD may be the most valuable predictors.
4.Comparative study on the clinical efficacy of triple needling and conventional acupuncture in the treatment of cervical spondylosis of vertebral artery type
Shangzhen GAO ; Yanling LI ; Xiaoning ZHANG ; Xuyun ZHOU
Chinese Journal of Primary Medicine and Pharmacy 2010;17(18):2464-2465
Objective To compare the clinical efficacy of triple needling and conventional acupuncture in the treatment of cervical spondylosis of vertebral artery type. Methods 49 cases with cervical spondylosis of vertebral artery type were randomly divided into two groups ,24 patients of control group treated with conventional acupuncture,25 patients of observation group treated with triple needling,the clinical results of two groups were compared. Results The obvious effective rate of the observation group was significantly higher than the control group, there were significant differences between two groups( x2 =4. 69 ,P < 0. 05). The improvement of average flow velocity(Vm) of the observation group was better than the control group, there was significant difference between two groups ( P < 0. 05 ).Conclusion Triple needling in the treatment of cervical spondylosis of vertebral artery type had better clinical results, and it was worthy of concern.
5.Late course accelerated three-dimensional conformal radiotherapy for esophageal carcinoma
Lan WANG ; Chao GAO ; Xiaoning LI ; Dongjie Lü ; Chun HAN
Chinese Journal of Radiation Oncology 2010;19(1):14-17
Objective To investigate the result and side effect of late course accelerated three-di-mensional conformal radiotherapy (3DCRT) for esophageal carcinoma. Methods From July 2003 to March 2006, 55 patients with esophageal carcinoma receiving 3DCRT were randomly divided into late course accel-erated radiation group (group A, 27 patients) and conventional fractionation group (group B, 28 patients). The prescribed dose in group B was 64 -66 Gy, 2 Gy per fraction, 1 fraction per day, 5 fractions per week for about 6.5 weeks. Patients in group A received conventional fractionation irradiation for the first 4 weeks. Then the dose was increased to 3 Gy per fraction to a total dose of 67 -70 Gy. The treatment course in group A was about 6 weeks. The treatment response, acute site effects, 1-, 3-and 5-year local control rates and o-verall survival rates of the two groups were observed. Results In group A, 23 patients (85%) achievedcomplete response (CR) and 4(15%) achieved partial response (PR). While in group B, 16 patients (57%) achieved CR and 12(43%) achieved PR. The CR rate was significant higher in group A (χ~2 = 5.24,P=0.022). The 1-, 3-, 5-year local control rates were 85%, 54%, 54% in group A, and 70%, 56%, 33 % in group B (χ~2 = 0.68, P = 0.409), respectively. The 1 -,3-,5-year overall survival rates of the two groups were 81%, 37%, 29% and 61%, 39%, 23% (χ~2 = 0.06, P = O. 804), respectively. Both lo-cal control and overall survival were similar between the two groups. The incidences of acute radiation esoph-agitis in the two groups were similar (85% vs. 89% ;χ~2 =0. 00,P=0. 959), and the incidence of radiation pneumonitis was slightly higher in group A than in group B (67% vs 43% ;χ~2 =3.14,P =0.076). By the last follow up, 19 patients in group A and 21 in group B died. Among them, 10 in group A and 15 in group B died of local failure, while 7 in group A and 5 in group B died of metastasis. Conclusions When com-pared with conventional fractionation 3DCRT, late course accelerated 3DCRT for esophageal carcinoma can achieve better results in clinical response, though not in long-term local control or survival. The incidence of acute radiation esophagitis and pneumonitis is clinically acceptable.
6.Clinical Observation of Acupuncture plus Paroxetine for Depression Due to Liver-qi Stagnation
Xiaoning LI ; Song GAO ; Lei WU ; Jilin MEI ; Nuo LI
Shanghai Journal of Acupuncture and Moxibustion 2017;36(2):138-141
Objective To observe the clinical efficacy of acupuncture plus Paroxetine in treating depression due to liver-qi stagnation, for seeking a more effective treatment for this disease.Method Sixty patients with depression due to liver-qi stagnation were randomized into a treatment group and a control group, 30 cases in each group. The treatment group was intervened by acupuncture plus Paroxetine, while the control group was by Paroxetine alone, successively for 8 weeks. Hamilton Depression Scale (HAMD), Chinese medicine syndrome and sign score, and central neurotransmitters were observed before and after the treatment, for evaluating the therapeutic efficacy.Result The total effective rate was 96.6% in the treatment group versus 71.4% in the control group, and the treatment group was superior to the control group (P<0.05).Conclusion Acupuncture plus Paroxetine is an effective method in treating depression due to liver-qi stagnation.
7.Survey on the cleanliness of health care workers' hands and uniforms in a hospital
Kaihua GAO ; Hongju TAN ; Xinmao ZHAO ; Lin REN ; Xiaoning YUAN
Chinese Journal of Infection Control 2017;16(4):314-317
Objective To understand the cleanliness of hands and uniforms of health care workers(HCWs)while they were working in a hospital.Methods Specimens of hands and uniforms of HCWs while they were working were collected and detected.Results A total of 342 specimens were collected, 173 were specimens from hands and 169 were from uniforms, the total qualified rate was 78.65%,qualified rates of hands and uniforms were 76.30% and 81.07% respectively.Qualified rates of hands and uniforms of different HCWs were compared respectively, differences were both statistically significant (both P<0.05);qualified rates of hands and uniforms of nurses were both highest (87.93% and 92.86% respectively), followed by doctors (75.86% and 87.72% respectively), while medical auxiliary persons were the lowest(64.91% and 62.50% respectively).Correlation analysis between qualified rates of hands and uniforms of HCWs in general wards showed that the correlation coefficient was 0.930 (P<0.01).Conclusion Cleanliness of hands and uniforms of HCWs needs to be further improved, especially medical auxiliary persons;cleaning frequency and cleanliness standard of HCWs' uniforms needed to be studied further.
8.The Pattern of Lymphatic Metastasis and Influencing Factors of Thoracic Esophageal Carcinoma
Jun WANG ; Chun HAN ; Shuchai ZHU ; Chao GAO ; Xiaoning LI
Chinese Journal of Clinical Oncology 2010;37(2):90-93
Objective: To explore the pattem of lymphatic metastasis and influencing factors of thoracic esophageal carcinoma. Methods: We reviewed the pathological specimens from 229 esophageal carcinoma patients who underwent radical esophagectomy with two-field lymphadenectomy. A total of 2,458 lymph nodes were dissected. We analyzed the lymph node metastasis pattern of the primary tumor in different loca-tions and the corresponding influencing factors such as pathological T stage, tumor length, pathological mor-phology and tumor differentiation. Results: Lymph node metastasis rates were 44.5% (102/229) and 10.5% (258/2458), respectively. For patients with upper thoracic esophageal carcinomas, lymphatic metastasis rates in the superior mediastinum, the middle mediastinum, the inferior mediastinum and the abdominal cavity were 19.0%, 6.7%, 9.8% and 12.2%, respectively. For patients with middle thoracic esophageal carcinomas, the rates were 26.1%, 7.4%, 11.8% and 11.9%, respectively. For patietns with lower thoracic esophageal carcino-mas, the rates were 0, 1.6%, 5.3%, and 10.0%, respectively. Lymphatic metastasis rate in T_1, T_2, T_3, T_4, stage cancer were 28.6%, 43.8%, 47.6%, and 31.3%, respectively; the rate of positive lymph nodes were 7.9%, 10.8%, 10.7%, and 10.8%, respectively, with no significant differences among the four stages (x~2=2.733, P=0.435 and x~2=0.686, P=0.876). Lymphatic metastasis rate and rate of positive lymph nodes in patients with tu-mor ≤3cm, 3 to 5cm, and >5cm were 45.2% and 43.4%, 46.2% and 9.1%, and 11.6% and 11.7%, respective-ly, with no significant differences (x~2=0.094, P=0.954 and x~2=3.933, P=0.140). Lymphatic metastasis ratios of the pathological morphology in medullary, ulcerative, mushroom and stenotic types were 14.0%, 9.6%, 4.3% and 18.3%, respectively (x~2=19.292, P=0.000). Lymphatic metastasis rate and rate of positive lymph nodes of squamous cell carcinoma of moderately and poorly differentiation were 42.5%, 75.0% and 9.5%, 18.6%, re-spectively (x~2=4.852, P=0.028 and x~2=11.323, P=0.001). Patients with squamous cell carcinoma of poorly dif-ferentiation had a higher rate of lymph node metastasis. Conclusion: Lymphatic metastasis of esophageal car-cinoma metastasize widely even if in early T stage. Pathological morphology and tumor differentiation are re-lating facors of lymph node metastasis of thoracic esophageal carcinoma.
9.Clinical Study on Bedbound Period after Coronary Arteriography
Huiping SUN ; Yajing LI ; Lihui GAO ; Yingxiao LI ; Xiaoning WANG ; Guorong WEI ; Junlian ZHANG
Chinese Journal of Practical Nursing 2001;17(6):3-4
Objective To find out the appropriate bedbound period after Coronary Arteriography (CAG) in order to reduce the complications and uncomfort caused by prolonged Bedbound period and affected limb immobilization.Methods 121 cases of CAG patients were randomly divided into the reduced period group (experiment group) and the conventional group (the control group),two ways of nursing and observation respectively.Result the rate of complication occurred in the experiment group much less than that of in the control group and the bedbound period were different as well.The above items showed statistics significance (P<0.005~0.05).Conclusion The reduced bedbound period decreases the suffering of CAG patients and provides the reliable clinical evidence for proper nursing approach in this field.
10.Analysis of relationship between CT-GTV and prognosis in patients with esophageal cancer after three-dimensional radiotherapy
Xiaoning LI ; Lan WANG ; Chun HAN ; Jie KONG ; Jing ZHANG ; Hua TIAN ; Chao GAO
Chinese Journal of Radiation Oncology 2014;23(1):23-26
Objective To observe the relationship between computed tomography-gross tumor volume (GTV) and non-surgical T stage in patients with esophageal squamous cell carcinoma (ESCC) and the survival rates of patients with different GTVs,and to investigate the impact of GTV on the prognosis of ESCC after three-dimensional radiotherapy.Methods A retrospective analysis was performed on 223 ESCC patients without lymph node metastasis and distant metastasis who were hospitalized from July 2003 to January 2009.The prescribed doses of three-dimensional radiotherapy ranged from 50-70 Gy.These patients were divided into 3 or 4 groups according to different percentile intervals of GTVs.The Spearman rank correlation analysis was used for investigating the relationship between non-surgical T stage and GTV.The Kaplan-Meier method was used for calculating survival rates,and the log-rank test was used for survival difference analysis.Results The follow-up rate was 98.2%.A total of 163 patients were followed up for at least 3 years.The median GTVs of patients with T1 +2 ESCC,T3 ESCC,and T4 ESCC were 19.31 cm3,33.69 cm3,and 41.25 cm3,respectively,exhibiting a positive correlation between non-surgical T stage and GTV (P =0.000).The 5-year survival rates were 59%,43%,and 24% (P =0.000) in 3 GTV-based groups and were 55%,51%,31%,and 24% (P =0.004) in 4 GTV-based groups.The primary cause of death for the patients with GTVs of ≤35 cm3 and >35 cm3 was failure of local control (57.9% vs 52.1%) ; 21.9% and 13.8% of the patients with a GTV of > 35 cm3 died of uncontrol and excessive bleeding,versus 9.4% and 3.1% of the patients with a GTV of ≤ 35 cm3 (P =0.046 ; P =0.029) ;2 of the patients with a GTV of > 35 cm3 died of grade 5 radiation pneumonitis.Conclusions GTV is positively correlated with nonsurgical T stage in esophageal cancer patients who receive radiotherapy.The 3-level and 4-level grading of GTV can be used for prognostic evaluation,and the 3-level grading of GTV is more closely related to prognosis.The patients with a larger GTV have higher incidence of uncontrol and bleeding and risk of treatment-related death than those with a smaller GTV after radiotherapy.