Objective? To explore the effect of applying sensitive indicators of emergency nursing in quality control closed loop management system, and to promote the development of emergency nursing quality management towards refinement, standardization and homogenization. Methods? By reviewing the literatures of emergency nursing sensitive indicators and quality control evaluation indicators at home and abroad in recent five years, the closed-loop management scheme of emergency nursing quality sensitive indicators was constructed, and further improved through training and feedback control. The difference of sensitive indicators of emergency nursing quality before intervention (2017) and after intervention (2018) in the Fourth Hospital of Harbin Medical University were compared. Results? After applying the closed-loop management scheme of quality control for sensitive indicators of emergency nursing, the excellent rate of emergency department specialist training, hand hygiene compliance of nurses, accuracy rate of pre-examination and triage, qualified rate of average residence time of critical patients in green channel, accuracy rate of patient identification, patient satisfaction and coverage rate of health education increased, and the difference was statistically significant (P＜ 0.01). Conclusions? The application of closed-loop management scheme for sensitive indicators of emergency nursing quality has a positive guiding effect on the quality control of emergency nursing, and can provide objective and accurate quality evaluation criteria for emergency nursing managers.