Objective To investigate the diagnostic value of biexponential model of DWI in nontypical hippocampal sclerosis (HS) of the youth.Methods DWI with multiple b values were performed on 75 youths with right temporal lobe epilepsy and 20 healthy youths(control group).There were no abnormalities in hippocampus on conventional MRI.11 of 75 patients were proved right HS by surgery and pathology (HS group).Compare the volume of the right hippocampus and their D,D? and f values in HS group and control group.Results There were statistical differences in D and f values between HS group and control group (Z=-3.08,Z=-2.23,P<0.05). There were no statistical differences in the volume of hippocampus and D? values between two groups (Z=1.77,Z=-0.19,P>0.05). Conclusion When HS does not have typical appearances on conventional MRI,D and f values can provide help from diffusion and the perfusion of microcirculation aspects.

Objective To investigate the relationship of D-dimer(DD) and fibrinogen levels in blood plasma and diabetic nephropathy(DN).Methods According to the results of urinary albumin excretion rate (UAER), 98 cases of type 2 diabetas were divided into simple diabetic mellitus ( SDM), early diabetic nephropathy ( EDN) and clinical diabetic nephropathy (CDN); other 45 healthy persons were employed as control. Plasma levels of DD and the fibrinogen of all groups were examined.Results There was significant difference of DD and fibrinogen levels in all groups as compared with control group (P

Lower urinary tract symptoms due to benign prostatic hyperplasia is of great prevalence among ageing males,and it can markedly affect patients' quality of life.Personalized drug therapy according to genetic characteristics is the ideal choice for this problem.Here we summarized the latest research findings on the associations of gene polymorphisms with drug efficacy and adverse reaction in the treatment of benign prostatic hyperplasia/urinary tract symptoms.

With the continuous development of modern chemistry, biology and pharmacy, researches on TCM modernization has witnessed a wide range of application of related modern technology, especially in researches of TCM monomer efficacy and pharmacokinetics. This can provide basis to internationalization of traditional Chinese medicine. The current research focus is how to obtain targeted TCM monomer. This article expounded the screening methods for TCM monomer at home and abroad, the principles of screening, the limitation and meanings.

Objective To investigate the characterized imaging in conventional MRI, get information about the metabolites in basal ganglia from proton MR Spectroscopy(~1H-MRS) of acute bilirubin encephalopathy(ABE) and find out the relationship between those changes and bilirubin levels. Methods Twenty-eight patients with acute bilirubin encephalopathy and 15 normal neonates underwent MR and ~1H-MRS examinations T_1 WI, T_2WI and DWI were collected via conventional MRI scanning of all neonates. All patients underwent multi-voxels scanning and 15 of them had single voxel scanning. ~1H-MRS used point resolved spectroscopy (PRESS) both in multi-voxels and single voxel scanning. The data of them were acquired from the ROIs placed in basal ganglia and globus pallidus, respectively. The metabolites including NAA choline, Lactate, glutamate and glutamine, myoinositol and creatine were quantitatively analyzed to compare them between the control group and the case group. Equality of variance between patient data and normal values were tested by using the two-tailed t test. The case group was divided into three groups of 342.0 μmol/L < TSB ≤ 427. 5 μmol/L,427.5 μmol/L < TSB ≤ 513.0 μmol/L, TSB > 513.0 μmol/L including 8,9,11 patients, respectively. Analysis of variance was used for statistics. Results Conventional magnetic resonance imaging showed symmetrical high signal of T_1WI in globus pallidus of 23 patients. The case group and the control group were significantly different. Single voxel ~1H-MRS revealed that the relative concentrations of Glx/Gr and mI/Cr in the control group were 0.95±0.23, 0.57±0.20, respectively, While those in case group were 1.45±0.37, 0.74±0.23, respectively. There were significant differences between two groups (t =2. 13,4. 40,P =0.04,0.00 respectively). Multi-voxels scanning 1H-MRS revealed that Glx / Cr were 0.51±0.36 in case group and 0.29±0.18 in control group. There was also a significant difference between two groups (t =2.17,P =0.03). And the values of Cho/Cr, NAA/Cr and Lac/Cr were not significantly different. The results were same in multi-voxels ~1H-MRS. Total bilirubin level and the concentration of metabolites in the brain do not have obvious correlation. Conclusions ABE has a characteristic signature which is symmetrical high signal of T_1 WI in globus pallidus on conventional MBI; The values of mI/Cr and Glx/Cr remarkably increase as detected by ~1H-MRS, which is generally in agreement with what has been known about bilirubin pathology.

o statistical difference between WMD group and control group (t = 1.83, t = 0. 88, P 0. 05). Conclusion Conventional MRI is able to quantify the brain maturation and prognosis of premature infants using TMS.

Objective To study of relationship between elderly people's alexithymia and mind-reading. Methods There were 108 old people over 70 years old, tested by mind-reading,cognitive ability and twenty-item Toronto alexithymia scale. Results There were significant difference in mind-reading(16.00±4.84, 19.36±2.91,t =3.38,P ＜0.01), memory span(5.80±1.42,7.18±1.13,t =4.28,P ＜0.01), working memory( t =4.05,P ＜0.01),processing speed( t =-4.80,P ＜0.01) between high and low alexithymia groups.Alexithymia scores were negatively related to the scores of mind-reading, memory span,working memory,processing speed,correlation coefficient was 0.227( P <0.05),-0.377( P <0.01),-0.334( P <0.01),-0.470( P <0.01),respectively. With mind-reading,cognitive processing and educational level as independent variables,with total scores, F1, F2, and F3 of TAS as dependent variable,respectively,the regression equation of total scores was significant( F =8.594,P ＜0.01), and the one of F1 was significant( F =8.796,P ＜0.01),but the one of F2( F =1.735,P ＞0.05) and F3( F =1.181,P ＞0.05) was not significant. Conclusion Elderly people's alexithymia is negatively related to mind-reading and several cognitive abilities. Mind-reading could affect emotional recognition, but not affect emotional description and export-oriented thinking.

The membrane fluidity of mitochondria isolated from langendorff perfused rat hearts was studied with ESR spin labeling technique and TBA method was used to detect the content of lipid peroxide. After total ischemia for 40min followed by a 20min reperfusion the 10-DSA region of the mitochondrial membrane showed significantly increased S (0.1(?)2?0.006) and ?_c(7.13?0.09?10~(10)sec) values (i. e. a decrease of membrane fluidity)in comparison with aerobic control (S=0.103?0.007); ?_c=6.86?0.20?10~(-10) sec) (P0.05). In addition, we found that DS182 could remove O_2~? produced by O_2~? generating system. Our results have showed that DS-182 is a potent scavenger of superoxide. The protective effect of DS-182 on mitochondria during ischemia/reperfusion might be due to its antioxidative activity。

This study was performed on rabbits to examine the changes of calmodulin (CAM) and cAMP in the myocardium during ischemia and reperfusion by radioimmunoassay method. The result showed the levels of CaM and cAMP increased at 20 min of ischemia. Although these two parmeters were unchanged at 40 min of ischemia as compared with the changes at 20 min, they were changed during reperfusion at different times of ischemia. At 20 min ischemia following 10 min reperfusion, the content of CaM decreased, the content of cAMP increased. On the basis of 40 min ischemia, reperfusion induced opposite changes: CaM increased, cAMP decreased. The possible mechanism of these changes was discussed.

We studied the protective effects of redix salviae miltiorrhizae (RSM) on the ischemic and post-ischemic reperfusion injury which was made by ligating and reopening of the left ventricular branch of the coronary artery of the open-chest anaethetised rabbits under the supervision of ECG. There were 14 rabbits in each group, 7 of them for the measurement of myocardial lipid peroxide level (MLPL) by the thiobarbituric acid method (Hiroshi Ohkawa, 1979), and the other 7 for measuring distribution of regional myocardial blood flow (RMBF) by the biological radionuclidelabeled particle method (Wang Jingxian, 1985). With increasing duration of ischemia, MLPL increased significantly in the ischemic and post-ischemic reperfusion injured heart. In the case of 60 mins ischemia followed by 30 mins reperfusion, MLPL was much higher than that without reperfusion. However, which compared with that of 90 mins ischemia, no significant difference was found. The recovery of RMBF was only 53.2% after 30 mins of reperfusion following 60 mins of ischemia. The occurance of post-ischemic reperfusion injury was dependent on the duration and severity of ischemia. The injury of reperfusion after long period (60 mins) of ischemia is similar to that of increasing duration of ischemia. No-reflow phenomenon was observed in ischemic zones during reperfusion after 60 mins of ischemia. In the RSM (2g/kg body wt) protected reperfusion group. MLPL was reduced by 56.0% and the recovery of RMBF was increased by 32.0%.