砄bjective:To study the effects of superlong pedicled latissimus dorsi muscle transplantation (SPLDMT) in the treatment of facial paralysis.Method: 16 cases of unilateral long standing facial paralysis were treated with SPLDMT in 1991～1998;follow up was conducted and the effects were analysed. Results:After operation satisfied movement recovery of the facial muscles was observed in 12 and improvenent in 3 of the 16 patients,no change was found in only 1 case. Conclusion: SPLDMT is effective in the treatment of unilateral long standing facial paralysis.

OBJECTIVE:To discuss the method of efficacy evaluation of Chinese traditional medicine(CTM)by the theory of pharmacoeconomics.METHODS:Based on the characteristics and the market situation,together with the current interna?tional pharmacoeconomics evaluation norm,the method for the efficacy evaluation of CTM was analyzed and discussed.RE?SULTS&CONCLUSIONS:Both the advantages of CTM and the international evaluation standard should be taken into consideration in the evaluation of the efficacy of CTM,it is advisable to adopt the western medicine efficacy assessment stan?dard if possible so as to increase its international acceptability.

Objective To summarize the experience on bronchiallavage to cure pulmonary atelectasis and pulmonary infection after thoracotomy.Methods 48 patients were selected and treated by bronchiallavage under monitoring,and antibiotics was used according to sputum culture and drug sensitive test.The out come was analyzed and evaluated.Results All patients of the pulmonary atelectasis were cured and those with pulmonary infection were controled.There was no serious complication.Conclusion Bronchiallavage is applied to treat pulmonary atelectasis and pulmonary infection after thoracotomy,the curative rate is significant.The appliance of antibiotics is guided by drug sensitivity.It is such a safe and feasible therapeutic tool that the bronchofibroscope is applied to cure pulmonary atelectasis and pulmonary infection after thoracotomy.

Thyroid carcinoma is the most common endocrine maligancy, and the worldwide incidence has been rising in recent years. Differentiated thyroid carcinoma is the most common thyroid malignancy, which include thyroid papillary carcinoma and follicular thyroid carcinoma, accounting for about 90 percent of thyroid carcinoma incidence. Currently, surgical treatment, iodine radiotherapy and TSH suppressive therapy are the commonly accepted effective treatments for differentiated thyroid carcinoma, and most patients can be cured. But there are still some patients not sensitive to the general treatments, who have lost the treatment of opportunity. Molecular targeted therapy is an agonistic or suppressive treatment for molecular biology targets of malignant tumor, and currently is a frontier research in the field of malignancy treatment. By retrieving and analyzing the related literature of molecular targeted therapy of thyroid carcinoma through PUBMED in the past 5 years, the article introduced the current status of molecular targeted therapy of thyroid carcinoma.
Adenocarcinoma, Follicular ; drug therapy ; Carcinoma ; drug therapy ; Carcinoma, Papillary ; Humans ; Molecular Targeted Therapy ; Thyroid Cancer, Papillary ; Thyroid Neoplasms ; drug therapy

Objective To study the effect of Mushao composition on ?-EP and CCK-8 in the caudex dorsalis of rats with pain after fracture operation,and explore its mechanism.Methods The male Wistar rats were randomly divided into control group,model group,Mashao composition group and tramadol group.The Brennan model was adopted.The level of the ?-EP and CCK-8 were determined by the method of radioimmunity.Results Compared with model group,Mushao composition could increase level of ?-EP in the caudex dorsalis,while decrease level of CCK-8.Conclusion Mushao composition could increase the content of ?-EP and reduce the content of CCK-8,so to analgesia in rats model of pain after fracture operation.

Objective To define urban community public health service programs by classification so as to better the mechanism of compensation for community health services. Mothods A preliminary classification of community health service programs was made in accordance with public product theories, which was then further improved by means of interviews with focal groups. Results At present a total of 99 community health service programs were offered in the cities under investigation, of which 45 were public health service programs, 21 para-public health service programs, and 33 private health service programs. Conclusion On condition that basic public health service is guaranteed, the government can make corresponding adjustments in compensation for public and para-public health service programs in light of economic development.

The paper sums up quality management in obstetrics in Shanghai in the past 10 years and gives an account of the specific measures adopted: laying a solid foundation of quality management in obstetrics and creating a sound organizational framework;valuing the crux of quality management in obstetrics and strengthening the control of process quality;stressing quality improvement in obstetrics and the analysis and feedback of outcome information and guiding the formulation of short-term and long-term action plans.It also describes the marked results obtained,including a reduced maternal mortality rate,enhanced access criteria for maternity hospitals,and preliminary results attained after the establishment of maternity hospitals for women from other areas.In addition,the paper puts forward suggestions for further improving maternal healthcare and obstetric quality.

The paper reviews the background and current situation of medical disputes and puts forward the concept of the reaction chain of medical disputes in view of their high occurrence rate and the difficulty in handling them. It discusses the framework, chief content, basic principles and major features of the reaction chain of medical disputes and argues that as a commonly used tool for handling medical disputes, the reaction chain renders it possible to check from the angje of the interests of the patients whether each party involved in the dispute has fulfilled its duties. Intended to improve the professional ethics of the physicians and the quality of medical care and calling on the patients to rebuild their confidence in the physicians, the reaction chain indicates that it is necessary to scientifically analyze the entire process and various influencing factors of medical disputes and bring into play the advantages of integration so as to successfully resolve medical disputes.

Objective To induce highly active hepatocellular carcinoma (HCC) specific cytotoxic T-lymphocyte (H-S-CTL) lines by co-culture of lymphocytes and hepatocellular carcinoma cells. Methods H-S-CTL were established by co-culture of autologous HCC cells and lymphocytes, under stimulation of IL-1,IL-2,IL-4 and IL-6.The cytotoxic activity of H-S-CTL for target cells were detected by 51Cr release assay and indirect immunofluorescence assay. Results Compared with auto-LAK, H-S-CTL showed much higher antitumor activity of significantly increased CD3+, CD4+ and CD8+ cells. Conclusions H-S-CTL lines with massive proliferations and high antitumor activity can be successfully obtained by ex vivo co-culture under the stimulation of interlukins.

DNA methylation is an important epigenetic modification mode , which plays a crucial role in gene expression , genome stability and development .DNA methylation is catalyzed and maintained in cell proliferation by the family of DNA methyltransferases.The ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC).Here, we briefly describe the TET enzymes and their role in cancer , and the distribution , the role and detection method of those three oxidation products of cytosine in genome .