Objective To investigate the short and long-term effects of flupentixol-melitracen after percu-taneous coronary intervention( PCI) .Methods 86 patients with coronary heart disease who would be given PCI were randomly divided into 43 cases of the study group and 43 cases of the control group.The control group was given conventional treatment after surgery, the study group was given flupentixol -melitracen on the basis of the control group.After one course,the mental status changes and short-term effect were observed.All the patients had been follow-up for 1 year to observe the occurrence of cardiovascular events.Results After one course,the HAMA and HAMD in the study group and the control group were (7.46 ±2.53) points and (15.74 ±3.16) points,(8.03 ± 1.97)points and (16.42 ±3.67)points respectively,which in the study group were lower than the control group (t=13.413,13.208, all P <0.01 ) .The total effective rate of the study group was 97.67%, which was higher than 81.40%of the control group (χ2 =6.081,P<0.05).During follow-up,the incidence rate of adverse cardiovascular events in the study group was 6.67%,which was lower than 42.86%of the control group (χ2 =9.564,P<0.05). Conclusion The flupentixol-melitracen can effectively improve anxiety and depression, improve the recent thera-peutic effect of PCI,reduce the incidence of cardiovascular events,which worthy of promotion after PCI.

ObjectiveBy reviewing TCM research projects in Nanjing municipal hospitals from 2006 to 2010 (eleventh five-year plan), this study aimed to recognize the existing problems, put forward corresponding solutions, and help Nanjing municipal hospitals improve scientific research level.Methods Through field investigations and interviews with experts, this study set 139 research projects from 2006 to 2010 in 10 municipal hospitals in Nanjing as study samples. ResultsDuring 2006-2010, current situations in TCM research projects of Nanjing municipal hospitals were as follows:the number of TCM research projects was small, the research level was low, and the fund was little. TCM research resources were unevenly distributed;the overall quality of TCM human resources were not high;talent structure was unreasonable;great differences existed among different types of hospitals.ConclusionsDuring the eleventh five-year plan period, there were significant differences between TCM research projects and WM research projects in Nanjing municipal hospitals, such as the differences in number, level, fund and project channel. The study proposed that TCM research materials should be rationally allocated, related mechanisms should be perfected, the industrial structure should be optimized, and the pace of training and introducing TCM research human resources should be quickened, with a purpose of making contributions to TCM development in Nanjing.

In accordance with the theory of traditional Chinese and Western medicine and clinical observance, the author explained the cause, mechanism and symptoms of the unilateral neglect after stroke, and summarized the way to treat the unilateral neglect with acupuncture and moxibustion therapy.

Since the first description of tension-free herniorrhaphy and the developement of prosthetic ma-terial for inguinal hernia, many techniques have come and gone. We should deploy the idea of evidence-based medicine and clinical practice guideline, according to the pathogenetie condition and medical condi-tion, in order to make the best treatment perseription for patient under the condition of nomudization.

Objective To investigate the clinical characteristics of inferior acute myocardial infarction (IAMI) with different inferior ST segment change.Methods The clinical data of 64 cases with acute anterior wall myocardial infarction from January 2010 to February 2012 in the hospital were prospectivly analyzed.According to wall leads ECG ST segment in the change situation,they were divided into three groups,group A (16 cases),under the wall (]Ⅱ,Ⅲ,aVF) of at least two lead ST segment elevation ≥0.1mV,group B(26 cases) under the wall(Ⅱ,Ⅲ,aVF) of at least two lead ST segment depression,group C (22 cases) under the wall(Ⅱ,Ⅲ,aVF) only a lead or no ST segment change.The infarct related artery,acute anterior wall myocardial infarction with different inferior ST-T change (infarction related coronary artery,IRCA),the infarct size and heart function were studied.Results IRCA in the three groups was consistent.The comparison of IRCA among the three groups showed that,A group of patients with “around the apical LAD” COSCO segment,accounting for 81.25％,and 26 cases in B group were not “around the apical LAD”,which was not “around the apical LAD” in 18 cases,8 cases of non-“ around the apex” COSCO LAD,of 22 patients in C group,21 cases non-“ around the apical LAD”,1 case was “around the apical LAD” COSCO,and the difference was statistically significant(F =6.32,5.92,7.08,4.11,all P ＜ 0.05).Conclusion IRCA is the LAD of acute anterior wall myocardial infarction of inferior ST segment changes may be related with the length of LAD and the lesion site,changes of inferior ST segment of anterior wall AMI can predict the IRCA position and LAD morphology,consistent with most studies.Patients with anterior wall and inferior wall ST segment elevation if IRCA is “around the apical LAD”,the infarction area is smaller,better heart function.

Through discussing the traditional medical ethics culture and medical ethics,this paper pointed out the main problems in the teaching practice of medical ethics:it did not well handle the relationship between the inheritance of traditional culture and the absorption of foreign culture;it emphasized too much on the learning of analysis methods and tools of ethical problems but ignored the cultivation of personality and morality;the teaching curriculum of medical ethics is unreasonable.This paper discussed the similarities and differences between medical ethics and traditional ethics culture,gasped the common essence of ethics,and put forward to better improve the teaching of medical ethics through the construction of basic theory system,the settings and perfection of curriculum system,the construction and improvement of the curriculum evaluation system,and the inheritance of traditional medical ethics cultural.

Objective To observe the effect of strengthen rosuvastatin in the treatment of patients with paroxysmal atrial fibrillation in coronary artery disease and the influence on serum inflammatory factor, to provide reference for clinical treatment.Methods 176 coronary artery disease patients with paroxysmal atrial fibrillation were randomly divided into observation group and control group, 88 cases in each group.The control group was given rosuvastatin,10mg/d,qd.The observation group was given rosuvastatin,20mg/d,qd.The LAD and LVEF were detected by color-Doppler before treatment and after 6 months treatment.The fasting blood was exsanguinated for testing BNP,hs-CRP,TNF-α,IL-6.The incidence rates of sinus rhythm maintenance and embolic events were recorded. Results After treatment,the LAD of the observation group and control group were (41.50 ±4.61)mm and (42.21 ± 5.20)mm respectively,which were significantly lower than before treatment (t=3.959,3.863,all P<0.05),the LVEF were (76 ±6)% and (73 ±5)% respectively,which were significantly higher than before treatment (t =7.744,6.837,all P<0.01),there were no statistically significant differences between the two groups after treatment (t=1.140,0.579,all P>0.05).The BNP,hs-CRP,TNF-α,IL-6 levels of the observation group and control group after treatment were (173.44 ±32.45)ng/L and (203.33 ±42.16)ng/L,(4.54 ±1.34)mg/L and (5.44 ± 1.35)mg/L,(15.34 ±3.26) ng/L and (19.45 ±2.23) ng/L,(10.85 ±0.77) ng/L and (13.27 ±1.23) ng/L respectively,which were significantly lower than before treatment (t=5.855 and 3.533,3.857 and 3.534,6.436 and 4.545,5.743 and 3.925,all P<0.05),the BNP,hs-CRP,TNF-α,IL-6 levels of the observation group after treatment were significantly lower than the control group(t=3.546,3.214,3.176,3.414,all P<0.05).The total effective rate,sinus rhythm maintenance rate,embolic events incidence rate of the observation group and the control group were 93.18%(82/88) vs 79.55% (70/88),68.18% (60/88) vs 43.18% (38 /88),2.27%(2/88) vs 18.18%(16/88).The total effective rate,sinus rhythm maintenance rate of the observation group were significantly higher than the control group (χ2 =11.965,11.144,all P<0.01),the embolic event incidence rate was significantly lower than the control group (χ2 =12.129,P<0.01).Conclusion Strengthen rosuvastatin can effectively reduce the serum inflammatory factors and BNP,improve left atrial remodeling and left atrial function,the clinical efficacy and prognosis are significantly improved, it is worthy of clinical use in the treatment of patients with paroxysmal atrial fibrillation in coronary artery disease.

MicroRNAs ( miRNAs) play an important role in regulating various life activities .It has been confirmed that circulat-ing miRNAs are new biomarkers for the diagnosis of many diseases and closely related with their occurrence and progression .In recent years, miRNAs are found to exist stably in blood and other body fluids in forms of being encapsulated in microvesicle or binding with proteins.Their origins, existence forms and functions have become a hotspot of research in this field .This article reviews the recent studies on the origin , existence form and function of circulating miRNAs associated with cardiovascular disease , aiming to provide some evidence for miRNAs as the biomarker and target of cardiovascular disease .

Objective To evaluate effect of care bundle on preventing neonatal ventilator-associated pneumonia (VAP). Methods Eighty neonates who met the inclusion criteria were selected and randomly divided into trial group and control group,two groups of neonates were both given routine nursing care,trial group were implemen-ted care bundle to prevent VAP on the basis of routine nursing care. Incidence of VAP,average length of neonatal intensive care unit (NICU)stay,and average hospitalization expense were compared between two groups of neo-nates.Results A total of 80 neonates were monitored,trial group and control group were both 40 cases. Incidence of VAP in trial group and control group were 21.21‰ and 35.04‰ respectively(P<0.05);average length of NICU stay in trial group and control group were (17.84±4.03)d and (23.50±4.81)d respectively(P<0.05);average hospitalization expense in trial group and control group were(26200.71 ±389.45)yuan and (38506.36±582.13) yuan respectively(P<0.05).Conclusion Care bundle can effectively prevent the occurrence of VAP,reduce the length of NICU stay,decrease hospitalization expense,and improve nursing quality and satisfaction.

Objective We have recently shown that 5-azacytidine and butyrate can trigger apoptosis in human liver cancer cells. The purpose of our present study was to determine the effects of 5-azacytidine and butyrate on the invasion of liver cancer cells and the changes of the protein expression in the liver cancer cells during the treatment with these agents. Method Human liver cancer cell lines HepG2 and Hep3B were treated with either 5-azacytidine or butyrate; in vitro cell invasion, adhesion and proliferation, as well as the expression of the cell cycle inhibitory proteins p21waf1, p27kip1 and p53 were observed.Results Our results demonstrated that the combination of 5-azacytidine and butyrate effectively blocked in vitro invasion of these two liver cancer cell lines. Both agents inhibited the adhesion and proliferation of the liver cancer cells. The expression of p21waf1 and p27kip1 protein in the liver cancer cells was increased by the treatment with either agent. These two proteins may contribute to the inhibition of the liver cancer cells invasion.Conclusion Our finding suggests that the agents that specifically target the cell cycle inhibitor genes may clinically useful in the adjuvant treatment of liver cancers.