ObjectiveTo overview the relationship between translational medicine and Chinese medicine, and the developments of translational medicine in TCM. MethodsResearch and reporting literatures on translational medicine m TCM and western medicine were collated and analyzed. The development and application of translational medicine was introduced. ResultsTranslational medicine has been successfully introduced into the realm of TCM applications and researches. ConclusionThe rise of translational medicine will promote the development of Chinese medicine and provide better opportunities for innovation.

The establishment of overseas traditional Chinese medical book database provides a new approach to help Chinese medical researchers to catch on the overseas Chinese medicine development. Overseas traditional Chinese medical book database is introduced and the overseas development of Chinese medicine has been discussed by using statistic results from the database in this paper.

This paper discussed key factors and significations of development and construction of professional traditional Chinese medical library alliance. The targets of establishing the alliance is to provide on-line cooperative catalogue, documents exchange and OPAC (online public access catalog), the prescription of the alliance construction, and the latest trend of the alliance. The paper also explored the policy for constructing library alliaqce and put forward the developing treads of this alliance.

In the circumstance of information age,this article made an analysis on the publish and distribution channels of medical professional literature.With the prosperity and development of the publishing industry,and diversified distribution channels,medical professional literature personnel must comply with the pace of the times,actively extended interview channels.

In this paper, the history, problems being encountered in current situation and significance of carrying out standardization of TCM literature classification were discussed.

The author made a feasible study on the construction of public management system of traditional Chinese medical picture resources based on current existence of TCM pictures.Pictorial resources of original separation,multielement,isomerism,and scattered distribution,were united by physical and logical patterns for the purpose of enhancing their availability.Public management system plat Of TCM picture resources was set up,with the characteristics of practicability,novelty,originality,and suitability for scientific research,teaching and public propagate education.

Based on the Chinese knowledge network,Wanfang Database,VIP database,Baidu,Google,we collected and sorted papers published by professor Liu Changlin over the past years,and made a statistical analysis with the use of bibliometric methods to summarize outcomes of professor Liu Changlin in the research of Chinese medicine philosophy.This article demonstrated a high academic value and status of professor Liu Changlin and to provide useful information for the further study of Chinese medicine philosophy.

Big Data is a new conception after scholars have proposed the conception of Web2.0 and cloud computing.This paper focuses on traditional Chinese medical researchers in order to meet the challenges of big data era.It is suggested that TCM scientific researchers should establish the idea of lifelong learning,and emphasize information literacy,in order to grasp for the latest medical researching information to make effective contributions to research innovation and human health.

Objective To analyse the survival time and related factors of patients with brain stem glioma who received 3DCRT.Methods Thirty-six patients with brain stem tumor were admitted from October 2004 to December 2008 and all received 3D-CRT with the dosage (50-54 Gy,25-30 f,5-6 weeks).During treatment,the patients’ outcomes were analyzed by observing the changes of symptoms,signs and adverse radiotherapy reaction and all of them were followed-up in the next 3 years.The survival data were analyzed by Kaplan-Meire method.Results The median survival time was 9 months in the 23 pediatric patients and 15 months in 13 adult patients.One-,two-and three-year survival rates between pediatric group and the adult group were 43.5 ％ (10/13) vs 76.9 ％ (10/13),26.1％ (6/23) vs 46.2 ％ (6/13),8.7 ％ (2/23) vs 38.5 ％ (5/13).Karnofsky performance scale score at admission (x2 =20.059,P =0.000),tumor site (x2 =17.585,P =0.000),growth pattern (x2 =21.247,P =0.000) were associate with survival time.Conclusion 3DCRT is an effective therapy to brain stem glioma,childhood onset,pontine glioma,diffusion style and Karnofsky performance scale less than 80 are risk factors of poor prognosis.

Objective To investigate the relationship between phosphatidylinositol 3-kinase catalytic subunit α(PIK3CA) expression and the incidence and different pathological grade of gastric cancer, and the mechanism thereof. Meth-ods The expressions of PIK3CA, serine/threonine protein kinase (pAkt) and cell proliferation associated nuclear antigen (ki-67) in gastric carcinoma and adjacent tissues and normal gastric mucosa were detected by immunohistochemical method. The relationship between expressions of PIK3CA, pAkt and ki-67 and tumorigenesis was analyzed. The expressions of PIK3CA, pAkt and ki-67 in different pathological conditions of gastric tissues were analyzed. The relationship between tu-mor pathologic classification and differentiation were analyzed too. Results There were significantly higher expressions of PIK3CA, pAkt and ki-67 in gastric cancer (P＜0.05), which were the highest in the poorly differentiated gastric adenocarci-noma (P＜0.05). There were a positive correlation between expressions of PIK3CA, pAkt and ki-67 and different pathologi-cal levels of gastric carcinoma and adjacent tissues and normal gastric tissues (P＜0.05). Conclusion PIK3CA may be the initiating factor of PI3K/Akt signaling pathway, which induced phosphorylation of Akt and activation PI3K/Akt signaling pathway, promoting the proliferation, invasion and metastasis of gastric adenocarcinoma.