BACKGROUND:As one of common oral diseases, periodontitis is the leading cause of tooth loss in adults.
OBJECTIVE:To review the research progress on periodontitis treatment.
METHODS:A computer-based search was performed on the PubMed database and CNKI database for articles addressing periodontitis treatment. The key words were“periodontitis, treatment, tissue engineering, gene engineering”in English and Chinese, respectively. Final y, a total of 57 articles were included to review.
RESULTS AND CONCLUSION:Currently, the majority of scholars are stil focus to improve periodontal tissue, promote the regeneration and repair of periodonttal tissue. With the development of tissue engineering and gene technology in recent years, periodontitis has been treated from multiple perspectives and multiple aspects, to solve the problems of patients with periodontitis. However, some treatment methods are stil in their early stage and need in-depth research.

Objective To explore the clinical application effect of Shuxuening combined with ozagrel sodium in the treatment of cerebral infarction patients with psychological intervention.Methods120 patients with cerebral infarction were randomly divided into observation group and control group from January 2015 to June 2016.The control group was treated with intravenous ozagrel sodium and psychological intervention.The observation group was treated with control group based on the use of Shuxuening.ResultsThe clinical efficacy in the observation group was significantly higher than in the control group (P<0.05).The incidence of complications in the observation group was significantly lower than that in the control group (P<0.05).ConclusionThe combination of Shuxuening combined with ozagrel sodium and psychological intervention in the treatment of cerebral infarction, can effectively improve the patient's treatment efficiency, improve the physiological and psychological status of patients, and effectively reduce the treatment of patients with complications.

Objective To improve students' nursing skills by studying on the management method of skill training after class. Method 2 random sampled classes were investigated. One class was experimental group, and received student-oriented management method. The other was control group, and received ordinary management method. Result The experimental group was different from control group in training attendance, number of questions, theory and skills examination performance. There was significant difference between them. Conclusion Student-oriented management approach improves students' training interesting, students' self-management ability, organizational capabilities, ability of expression and critical thinking.

Objective To analyze the utilization and influencing factors for community health service (CHS)of the elderly population under the community first contact care background.Methods 1028 elderly citizens were investigated at their homes with a stratified random sampling method.Results The two-week prevalence rate was 29.56％ and the two-week visiting rate was 61.00％ of the elderly population surveyed.52.30％ of the surveyed objects were willing to choose community health service centers for outpatient.90.08％ of the surveyed could get to one community health service center in 15 minutes.The influencing factors of choosing community health centers were age,income,chronic illness,satisfaction of service quality of CHS and the skill of community physicians.Conclusions The utilization level of CHS need improvement for the elderly population.To improve the service quality of CHS and professional skills of community physicians are critical factors attracting elderly population to choose community health centers.

Objective To observe the efficacy and safety of venlafaxine on cognitive function in patients with post stroke depres-sion(PSD) .Methods 72 patients of cognitive dysfunction with PSD were selected and randomly divided into observation group and control group with 36 cases in each .The control group was treated with therapy for acute stroke .The observation group was treated with venlafaxine based on the treatment of control group .After 12 weeks of treatment ,the mini mental state examination(MMSE) , the Montreal cognitive assessment scale(MoCA) and activities of daily living scale(ADL) were used to evaluated the efficacy of the two groups before ,fourth weeks after and twelfth weeks after the treatment .The scores of the two groups were compared .The oc-currence of adverse reaction of the observation group was recorded .Results After 4 weeks treatment of the observation group ,the MoCA was (18 .52 ± 4 .37) .MMSE score was (20 .61 ± 4 .85) ,which were significantly higher than before treatment .And the ADL score was (35 .27 ± 4 .75) ,significantly lower than before treatment(all P<0 .05) .After 12 weeks of treatment ,the MoCA score of observation group was (20 .14 ± 5 .26) .MMSE score was (22 .46 ± 4 .59) .Which were all significantly higher than those of control group .While the ADL score was (29 .85 ± 5 .07) ,significantly lower than the control group(all P<0 .05) .The observation group with 2 cases had mild gastrointestinal discomfort ,2 cases with dizziness .Conclusion Venlafaxine can improve cognitive function in patients with post stroke depression .It can significantly improve patients′self-care ability and is safe .It can be further applied in the clinic .

OBJECTIVE: To design the dosage regimen of aminophylline using reported pharmacokinetic parameters (mean group value). METHODS: The calculation of oral maintain dose, the infusion rate of intravenous drip maintain dose and the loading dose of intravenous drip were introduced. RESULTS: Different dose were required for different pathophysiological conditions insteading of aminophylline 200 mg three times a day (p.o.) for every patient. CONCLUSION: It is recommended that all hospitals which are unable to determine plasma concentration should design dosage regime of aminophylline using pharmacokinetic parameters.

Objective To investigate the durability of the cryopreserved valved homograft conduit (VHC) used in reconstruction the right ventricular outflow tract (RVOT) and its risk factors. Methods 119 cases undergoing VHC reconstruction the RVOT in our hospital between November 1989 and July 2003. 65 cases were followed-up, including the clinical examination, electroeardiography, chest radiography, echooardiography, or cardiac MRI for detection of development of homograft calcifications, obstruction and conduit valve regurgitation, and we used the morden statistics method to analyze the factors for the VHCs' durability. Results Among 65 cases, the median survival time for the VHCs was 10.9 years. The longest survival lasted for 12.8 years.The homografts failure was 15.4% . Conclusion The younger age(≤4y), smaller weighl(≤10 kg),aortic homograft are the risk factors for the VHC' durability(P

OBJECTIVE To investigate the variation of in vitro activity,the ?-lactamases,type diversity and the homology of multiple resistances in Acinetobacter isolated.METHODS The multiple resistant Acinetobacter were selected to detect susceptibility test by K-B antimicrobial agents.The resistant rates were analyzed by WHONET 5.4,the isolates ?-lactamases phenotype was detected by three-dimensional test,genomic types were measured by PFGE.The ?-lactamases genotype was determined by PCR assay with specific-primer,and DNA sequencing was also used to analyze resistance-related gene.RESULTS Twenty-eight of 45 strains were OXA producing strains(68.3%),10 strains were IMP producing strains(24.4%),13 strains were TEM producing strains(31.7%),18 strains were CTX-M producing strains(43.9%),6 strains were PER producing strains(14.6%),and 7 strains were AmpC producing strains(17.1%).None produced SHV ?-lactamases.Twenty-four strains were produced 2 or more than 2 kinds of ?-lactamases.CONCLUSIONS The multiple resistance of Acinetobacter can produce kinds of ?-lactamases,but producing ?-lactamases are not the only one mechanism.

Objective To investigate the relationship between matrix metalloproteinase-9 (MMP-9) gene-1562 C/T polymorphism and hemorrhagic transformation (HT) from (IS) in Chinese Han population in Henan province.Methods The promoter-1562 C/T gene polymorphism in 84 IS patients with HT and 138 age-and sex-matched IS patients without HT were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).The genotypes and alleles frequencies of-1562 C/T polymorphism were analyzed.Results The frequency of CT and TT genotype and T allele was lower in IS patients with HT than in IS patients without HT (17.86％ (15cases) vs.30.43％ (42 cases),8.93％ (15 cases) vs.15.94％ (44 cases),x2=4.326 and 4.458,P=0.037 and 0.035).The relative risk for HT from IS was decreased in patients with T allele than those withCTandTTgenotype[0.517 (95％CI:0.278-0.961) vs.0.497 (95％CI:0.255-0.967)].Conclusions The MMP-9 gene-1562C/T polymorphism may be related to hemorrhagic transformation of in Chinese Han population in Henan province.The T allele is a protective factor for hemorrhagic transformation of in the population.

Objective To observe the effect of pravastatin on the expression of heat shock protein B7 (HSPB7) in acute myocardial infarction (AMI) rats. Methods A total of 80 AMI rats were randomly divided into AMI group and pravas-tatin (P) group. Forty SD rats were used as sham operation (SH) group. Rats were then subdivided into 1 h, 3 h, 6 h and 12 h subgroups (10 for each group). Rats were not ligated after thoracotomy in SH group. The 1eft anterior descending coronary ar-tery was ligated in rats of AMI group. The 1eft anterior descending coronary artery was ligated in P group and given intragas-tric administration of 0.5 mg/(kg · d) pravastatin. The other groups were given the same amount of normal saline via gavage. The left ventricle infarcted myocardial tissues were taken at each time intervals. The corresponding myocardial tissues were harvested in sham-operated rats. The HSPB7 mRNA and protein expressions were measured by RT-PCR and immunohisto-chemistry respectively.Results The expression levels of HSPB7 mRNA and protein were significantly higher in the AMI group and P group than those of SH group(P<0.01). The expression levels of HSPB7 mRNA and protein were significantly increased 1 h after AMI and reached the peak value at 3 h after AMI. The expression levels of HSPB7 mRNA and protein were still higher in 6-h group and 12-h group than those of SH group. The expression levels of HSPB7 were higher in differ-ent time points of P group than those of AMI group. Conclusion HSPB7 could express in the early stage of acute myocardi-al infarction in rats. Pravastatin could promote the upregulation of HSPB7 in myocardial infarcted border zone after AMI, which may play a protective role in early myocardial infarction.