OBJECTIVE: To evaluate the curative effect of Bushen huayu tiaozhou recipe on polycystic ovary syndrome (PCOS) in plateau section. METHODS: The herbs artificial cycle method was use as main therapy. No.1 recipe used after menstrual period was as follows: nourishing the blood, reinforcing kidney, perfecting thoroughfare vessel and conception vessel; No.2 recipe used for ovulation period was as follows: reinforcing kidney and Yang, regulating Qi to dissipate blood stasis during; No.3 recipe used before menstrual period was as follows: warming Yang, reinforcing kidney, regulating Yin and Yang; No.4 recipe used for menstrual period was as follows:regulating Qi,invigorating blood circulation, dissipating blood stasis and promoting menstruation recovery.After 3 months of oral administration therapy the curative effects were observed. RESULTS: The total effective rate was 90% and the total cure rate was 40.83%. CONCLUSION: Bushen huayu tiaozhou method has satisfactory effect on PCOS in plateau section by regulating Qi, Yin, Yang and thoroughfare vessel and conception vessel to recover the regulating function of reproductive axis containing brain, kidney, thoroughfare vessel, conception vessel and uterus.

Objective To explore the relationship between the plasma homocysteine(Hcy)level and carotid atherosclerosis in the patients with H hypertension .Methods 200 patients with essential hypertension were divided into the research group (complicating homocysteinemia) and the control group according to whether complicating homocysteinemia .Carotid artery was detected and its average intima‐media thickness (IMT) was measured for all the patients by GE LOGIQ3 type color Doppler ultrasonograph .Simul‐taneously ,the levels of plasma Hcy ,triglycerides ,total cholesterol ,high‐density lipoprotein cholesterol and low density lipoprotein cholesterol were detected .Results Average carotid IMT in the research group was significantly higher than that in the control group(P<0 .05) ,and with the increase of the Hcy level ,IM T was gradually thickened ;in addition ,the atherosclerosis degree of ca‐rotid artery was significantly associated with the Hcy level (P<0 .05) .Conclusion The Hcy level is closely related with the ather‐osclerosis degree of carotid artery in the patients with H hypertension .

Objective To study the value of the multiple tumor markers protein chip system (C‐12) in the clinical application . Methods The levels of 12 kinds of tumor markers were detected in 5 000 healthy people (healthy physical examination group) ,4 500 patients with benign tumor and inflammation (benign disease group) and 5 500 patients with malignant tumors (malignant tumor group) .At the same time 1 369 negative specimens in the malignant tumor group were performed the comparative analysis with the electrochemiluminescence method by adopting the fully automatic chemiluminescence immune analyzer .Results The posi‐tive rate in the malignant tumor group by using C‐12 was 75 .11% ,which was significantly higher than 20 .31% in the benign dis‐ease group and 4 .34% in the healthy physical examination group ,the difference between the two groups in pair had statistical sig‐nificance(P< 0 .05) .The sensitivity of C‐12 for detecting malignant tumor was 75 .11% ,the specificity was 95 .66% ,and the posi‐tive rate of joint detection was significantly higher than that of single marker ,the difference between them was statistically signifi‐cant (P< 0 .05) .Conclusion The 12 tumor markers protein chip joint detection method has certain reference value for the diagnosis in the patients with tumor .Detecting multiple tumor markers can obviously increase the diagnosis sensitivity of malignant tumors , can be used in the prognosis and the curative effect observation ,at the same time can also be used as one of screening measures for early tumor among asymptomatic population .

OBJECTIVE:To evaluate the marketing of hemostatic drugs use in China from 2006 to 2008.METHODS:By reviewing literature both at home and abroad and combining the data of the sales volume and consumption sum of hemostatic drugs from 2006 to 2008 and in the first 3 quarters of 2008 available in the "State Medicine Economy Information Network",the drug variety and manufacturers were analyzed statistically.RESULTS & CONCLUSIONS:Hemopexin assumed a dominate place in the market of hemostatic drugs,accounting for 38% of total in sales value,followed by tranexamic acid and aprotinin.Switzerland Sugao pharmaceutical factory ranked at the first place in terms of sales value of hemostatic drugs.

The anatomical and functional details of the anterior cruciate ligament (ACL) of the knee joint were studied on 55 normal cadaver knees of adults.ACL is made up of multiple fascicles, the basic unit of which is collagen. It is attached to the medial surface of the lateral femoral condyle and front of the anterior tibial spine. ACL is narrow in the middle and fans out at the attachments. The fascicles of ACL have been summarily divided into two groups: the anterior medial portion (AMP) and the posterior lateral portion(PLP). The tension of AMP is different from that of PLP during movement of the knee. ACL restricts the anterior drawer sign, and the internal and external rotation of the knee. AMP acts with the knee in flexion and PLP in extension. ACL restricts hyperextension, too. The function of ACL is related to its morpholcgical structure and the anatomy of the attachments. Rupture of ACL may result in instability of the knee, and injuries to the different components of ACL may produce different signs.

The author analyzed current situtation of teachers and students during clinical practice,and proposed that we should well attach importance to the training of behaviour,including working style,basic skill,clinical thinking and research idea,to improve the quality of medical education in clinical teaching,

Currently, the respiratory tract infection (RTI) is still one of the most common disease that seriously threatens children′s life and health. Timely detection of pathogens in clinical specimens of children with RTI is helpful to accurate diagnosis and reduce the irrational usage of antibiotics. It is also an important strategy to achieve the best clinical management of RTI in children. In recent years, in addition to the traditional staining and microscopy, culture and antigen detection, the polymerase chain reaction, syndromic approach testing and metagenomic next-generation sequencing have also been used for the diagnosis of pathogens in children with RTI, showing a good application prospect. This review aims to systematically summarize the classification of clinical specimens and the detection methods of common pathogens in the diagnosis process of childhood respiratory infections. This not only expands the understanding of pediatric medicine, but also provides more enlightenment for related research work.

Objective To investigate whether there are differences of the characteristics of the contrast‐enhanced ultrasound among breast cancer vary in size .Methods The contrast‐enhanced ultrasound perfusion mode were retrospectively analyzed in 113 cases of breast cancer patients with 119 lesions .They were divided into two groups according to the maximum diameter of the lesion based on ultrasound measured ,one group (≤2 0. cm ) 47 cases ,the other group (> 2 0. cm ) 72 cases .The characteristics and mode of contrast‐enhanced ultrasound of the lesion were analyzed ,including whether is greater than the two‐dimensional ultrasound in enhanced range ,enhanced strength ,the distribution of the contrast agent ,contrast agent perfusion sequence in lesions ,contrast mode ,and the existence of perforator vessels and perfusion defects .Results Enhanced strength ,the existence of perforator vessels and perfusion defects associated with the size of the lesions .The breast cancer lesions more than 20 cm were apt to higher enhance strength ,the presence of perfusion defects ,perforator vessels ( P < 0 0.5) .However ,there were something that had nothing to do with the size of the lesions including whether or not contrast‐enhanced ultrasound range was greater than the two‐dimensional ultrasound range ,contrast agent distribution characteristics ,contrast agent perfusion sequence in lesions ,and differences in contrast patterns ( P >0 0.5) .Regardless of breast lesions size ,the enhanced range tended to larger than two‐dimensional ultrasound range ,and contrast‐enhanced ultrasound present inhomogeneous ,centrality and integrity filling and perfusion mode of quickly rising and falling .Conclusions Within breast tumor angiogenesis is gradual .With the increase of tumor volume ,more significant vascular heterogeneity ,breast cancer lesion are more prone to uneven high perfusion ,accompanied by perfusion defects and perforating vessels ,but the main sign of differentiating benign and malignant showed consistency between different sized lumps in breast cancer ,which included whether or not contrast mode and enhanced range greater than two‐dimensional ultrasonic range .

Objective To study the ultrasonic imaging of breast cancer with or without filling defect with contrast-enhanced ultrasound and clinical pathologic correlation.Methods The suspicious breast lesions underwent contrast-enhanced ultrasound examination, the imaging of 1 1 9 breast cancer with pathological results were retrospectively analyzed,and the contrast enhanced ultrasound effect,distribution of contrast agent,sequence of contrast agent into the tumor,contrast enhanced ultrasound mode,perforator vessel,filling defect and flow classification were observed.Then clinical and pathological data were collected including the tumor size,clinical stage,pathological grade and the situation of micro calcification.The perfusion defect as the grouping factor,there were 37 cases of perfusion defect and 82 cases without perfusion defect.A mono-pactor and multi factor analysis was performed by the logistic regression models to the relationship between perfusion defect and contrast-enhanced ultrasonography,clinical pathological parameters.Results Both mono factor and multifactor analysis displayed that whether to display the filling defect in contrast enhanced ultrasound was associated with ultrasound contrast distribution,the sequence of contrast agent into the tumor and histological grade(χ2=19.5050,21.1210,10.3640,OR =6.977,0.261, 2.509,all P <0.05).Multivariate analysis showed that tumor size and whether to display the filling defect in contrast enhanced ultrasound were close(OR =1.692,P <0.05).Clinical stage,whether the blood flow signal penetrates was meaningful in univariate analysis but excluded in multivariate analysis.Both mono factor and multifactor analysis displayed that contrast enhanced ultrasound mode,contrast enhanced ultrasound effect,flow classification and pathological micro calcification were not associated with whether to display the filling defect.Conclusions Whether to display the filling defect and the related factors of contrast-enhanced ultrasound in diagnosis of benign and malignant were not completely consistent.Breast cancers with filling defects of contrast-enhanced ultrasound tend to present large masses,contrast agent distribution of peripheral enhancement,centripetal filling of ultrasound contrast agents and the higer histological grading.

Objective To study the short term and long term response and the safety of the different doses of recombinant interferon alfa 1b(IFN? 1b) for the treatment of the patients with chronic hepatitis B and the predictive factors of the response. Methods 146 Chinese patients with chronic hepatitis B entered randomly into four groups. Three groups were given with IFN ? 1b 3 million unit (MU), 5 MU and 10 MU respectively. The control group was given placebo. The short term(ETR) and long term(SR 12) responses and side effect were observed. Selected nineteen items (host related, drugs related and virus related), which affected the response of IFN alfa 1b probably (host, virus and drugs, et al) were analyzed. Results The end treatment response (ETR) of the IFN ? 1b 5 MU therapy was 55.3%, and 10 MU was 58.1%. Both efficacy were higher than the group of 3 MU IFN alfa 1b (32.6%) and control therapy group (5.9%, P