Triggering receptors expressed on myeloid cells-2 (TREM-2) is a newly discovered immunoglobulin receptor, which plays an important role in inflammation and immunoreaction. Several recent studies have shown that TREM-2 is aberrantly expressed in various types of cancers such as lung cancer, gastric cancer, liver cancer, colorectal cancer, renal carcinoma and glioma, and it is widely participated in regulating malignant tumor initiation, progression, invasion and metastasis through different signal pathways. TREM-2 is expected to provide evidence for the diagnosis and treatment of malignant tumors.

Objective:By means of balanced board,we can comprehensively assess the hospital and promote the hospital science progress from four aspects such as patient,finance,interior procedure,and the study and development.Method: Introducing the source content and character of the balanced board;Introducing the reason,qualification,instruction and effect for ChongQing NO 9 Hospital to apply the balance board.Result: We assessed the balance board from finance,interior procedure,patient,study and development: The hospital's operation income structure was more reasonable;the hospital's income is equal to the economic development;the medical staff's quality had been improved;the civilization and brand of hospital were generally promoted.Conclusion:Balance board can be used in the medical treatment and health care reformation.As a management method of hospital it can be combined with the hospital assessment items.When the hospital employs the balanced board,we can combine the management object and management cost,the development of hospital and patients' satisfaction,hospital income and local economical level as well as fee for medical treatment,performance and quality in order to promote the development of hospital.

Objective To explore the abnormal inflammatory cytokine profile of salpingitic infertility by means of cytometric bead assay(CBA). Methods To assay representative inflammatory cytokines of 40 patients of salpingitic infertility(PSI) and 40 healthy control by CBA, and compared 30 samples of serum with peritoneal fluid collected from identical subject. Results Experiment data displayed that in PSI the Th lymphocytes were decreased significantly (t =2. 1236,P <0. 05), Ts lymphocytes increased markedly, and the ratio of Th/Ts markedly decreased ( t = 2. 8392, P < 0. 01 ), compared with those of healthy control.(Pre-)inflammatory eytokines (IL-8, IL-1β, IL-6 and TNF-α) were all significantly higher than those of healthy controls ( t = 4. 9302,5. 5449,3. 4975,5. 6623, respectively, all P < 0. 01 ) ; while anti-inflammatory cytokines ( IL-10, IL-12 ), also increased markedly ( t = 5. 3428,5.9847, respectively, all P < 0. 01 ).Beside IL-10, all other cytokine concentrations presented in serum were higher than that of peritoneal fluid;IL-8(t =2.2113,P <0.05),IL-llS(t =2.9756,P <0.01), IL-6(t =2.3298,P <0.05), TNF-α (t =3. 2895, P < 0. 05 ), IL-12 ( t = 3. 3281, P < 0. 05 ), implying more sensitive of serum samples. Conclusion PSI displayed extensive disorders of the inflammatory cytokine network, CBA can be used to probe the disharmony condition at high through-out and high sensitivity.

Objective To study the effects of vascular endothelial growth factor(VEGF) in early stage diabetic retinopathy and their mechanisms,so as to guide the clinical work theoretically.Methods Thirty-six SD rats were randomly divided into four groups.Nine rats were used as normal controls(M Group).Streptozocin were injected intraperitoneally to induce diabetes for 1 month(M1 Group),2 months(M2 Group),and 3 months(M3 group).At the experimental ends of each group,the rats were over anesthetized and their eyeballs were extracted to make digest preparation.Immunofluorescence were used to investigate the expression of VEGF on retinal blood vessels.Transmission electromicroscopy was used to observe the histology of the retinal vessels.Results VEGF immunofluorescence showed an expression rate of 56% in M2 group and 89% in M3 group.Transmission electromicroscopy showed no change in M Group.However,it showed swelling of endothelial cells,finger like process into the capillary cavity,uneven distribution of heterochromatin in pericytes in M1 Group.Obvious fragmental thickening and splitting of basement membrane,swelling and deformation,finger like process to the capillary cavity,and concentration and margination of heterochromatin in endothelial cells,and swelling and deformation of rough surfaced endoplasmic reticulum and mitochondrion in pericytes were observed in M2 and M3 groups,especially in the latter.Conclusion The expression of VEGF proteins in the retinas of diabetic rats increases with the progression of diabetes.It proves that VEGF plays an important role in the occurrence and development of early diabetic retinopathy.

OBJECTIVE:To explore the cleaning action of rhizoma pinelliae mi xture(RPM)on trachea secretions of the model animals.METHODS:The rats were divided randomly into high and low dose of RPM group and the control group;Then the secretion level of phenol red in each group was observed after the forming of models by tracheostomy and intraperitonal injection with phenol red;The respective time that spent on moving cork wood filings to a same distance by oral mucosa ep ?ithelium ciliary movement of toad both before and after medication were observed.RESULTS:The secretion level of phenol red in RPM group increased significantly compared with the control group(P

Objective To explore the clinical effectiveness of the platelet parameter in neonatal hypoxic-ischemic encephalopathy(HIE).Methods From Oct,1999 to May 2001,50 cases of neonatal HIE were final diagnosed,the platelet total(PLT),mean platelet volume(MPV) and platelet distribution width(PDW) were dynamic observed.It was compared with 27 cases of normal term infant.Results ⑴PLT in acute period of HIE was obviously lower than that of the normal term infant(P0 05).⑵The PLT in the HIE was decreased(P

The Haemophilus influenzae (Hi) is a common opportunistic pathogen from human respiratory tract. The lower immunity can cause the disease. After the biofilm (BF) is formatted by Hi at the site of infection, the antibiotic sensitivity is declined, which often causes the chronic disease, inducing the difficulty in clinical treatment. In recent years, the pathogenic?ity of Hi BF and BF form related factors have gradually become the focus of clinical and basic research. This paper reviewed recent studies as following.

Objective To study the induction of dihydroartemisinin(DHA) on prostate cancer PC-3 apoptosis and its possible mechansim.Methods MTT was employed for cellular viability measurement,flow cytometry(FCM) and transmission electron microscopy(TEM) for observation of apoptosis,and immunocytochemical staining(SP) for analyzing the expression of Bcl-2 and Bax proteins in PC-3 cells treated with DHA of different concentration.Results DHA Significantly inhibited the proliferation of PC-3 cells,induced their apotosis in a time-concentration dependent manner,and led to mitochondrial swelling,nuclear fragmentations and apoptosis body formation,down-expression of Bcl-2 protein,and over-expression of Bax protein correspondence with DHA concentration.Conclusion DHA could induce the apoptosis in PC-3 cells by up-regulating Bax protein and down-regulating Bcl-2 protein.

Objective To evaluate the efficacy and toxicity of Taxol-based chemotherapy in patients with advanced gastric cancer. Methods Thirty-one patients with advanced gastric cancer were treated with two kinds of Taxol-based chemotherapy schedule. The treatment schedule were composed of paclitaxel and fluorouracil(TF) or cisplatin(TP). The patients who had had chemotherapy with fluorouracil were arranged to TP group,others to TF group. A treatment cycle lasted 21 days. The efficacy was evaluated after two cycles of the chemotherapy. Results total efficiency rate of two groups was 45.2 %; the efficiency rate of TF was 47.4 %; the rate of TP was 41.7 %; CBR was 80.6 %. The main side effect of toxicity were neutropenia and nausea as well as vomiting. Conclusion Taxol-based combination chemotherapy is a high response protocol with mild toxicity. TP schedule has a high efficiency for advanced gastric cancer.

AIM: To investigate the effect of bilirub in on acute lung injury (ALI) and the mechanism. METHODS: 30 male Wistar rats were divided into normal group, ALI group and bilirubin treatment group. Lung specimens were examined by histopatho logical te chnique. Lung index (LI) and lung permeability index (LPI) were measured. Moreov er, white blood cell (WBC) count, neutrophil percentage (PMN%) and the content o f protein (Pr) in the bronchoalveolar lavage fluid (BALF), as well as the conten ts of sup eroxide dismutase (SOD), malonaldehyde (MDA) and glutathione peroxidase (GSH-Px) in the lung homogenate were determined. RESULTS: (1) In ALI group: LI, WBC count, PMN%, Pr and LPI incre ased significantly compared with normal group (P 0.05) was observed. (2) In ALI group, the content of MDA was significantly high er (P0.05). CONCLUSION: Bilirubin relieves ALI induced by LPS in rats via an tioxidation.