OBJECTIVE:To evaluate the pharmacoeconomic effectiveness of three quinolones for respiratory tract infections.METHODS:A retrospective study was conducted in which a total of 94 cases with respiratory tract infection were randomly to receive levofloxacin(Group A),ciprofloxacin(Group B) or moxifloxacin(Group C).The therapeutic effects were monitored and the cost-effectiveness analysis was performed on the three treatment schemes.RESULTS:The costs of the three groups were 397.60,1 131.90,and 2 255.40 yuan,respectively;the clinical effective rates were 73.53%,85.71% and 93.75%,respectively(P

Objective To provide rational use of vancomycin in elderly MRSA-infected patients, compared its pharmacokinetics in the elderly MRSA-infected patients with healthy young subjects.Methods 15 elderly MRSA-infected patients and 15 healthy young subjects were injected with 1.0g vancomycin.Serum concentrations were determined by fluorescence polarization immunoassay(FPIA) in both groups(n infected=15,n healthy =15),then calculated the pharmacokinetic parameters with program 3p97.Results Compared with the healthy group, the elimination half life (t1/2β)were longer, the apparent volume of distribution (Vd)and the area under curve(AUC)were increased,the creatinine clearance(Ccr)were lower in the infected group.The differences of these pharmacokinetic parameters between the two groups were statistically significant(p<0.01) except the peak serum concentrations(p>0.05).Conclusion Vancomycin should be used with decreased dose or increased interval in the elderly MRSA-infected patients, therapeutic drug monitoring and personalized medicine were required.

Objective To investigate the interrelationship among urinary albumin elimination rate(UAER),serum adiponectin(ADPN)and blood glucose level in patients with type 2 diabetic nephropathy(DN). Methods A total of 89 type 2 diabetic patients and 30 healthy people as control were enrolled in the study.According to UAER,the diabetic patients were divided into three groups:normal group(35 cases,UAER＜30 mg/24 h),microalbuminura group (32 cases,UAER 30-300 mg/24 h)and macroalbuminura group(22 cases,UAER＞300 mg/24 h).Serum adiponectin was measured by ELISA.Body mass index (BMI),waist hip radio(WHR),fasting plasma glucose(FPG),2-hour plasma glucose(2hPG),glycated haemoglobin(HbAlc),blood lipid and UAER were measured routinely.Data were compared among groups. Results Serum adiponectin level was lower in diabetic patients than that in healthy control group(P＜0.05).Among diabetic patients.serum adiponectin of macroalbuminura group was significantly higher than that of normal and microalbuminura groups[(67.74±14.89)vs(39.36±13.92),(54.38±10.14)ng/L,P＜0.051.Multiple regression analysis showed 2hPG,HbAlc,BMI,disease course,UAER and DBP were closely associated with the level of serum adiponectin. Correlation analysis indicated serum adiponectin was positively correlated with age (r=0.255), disease course (r=0.405), HDL (r=0.501)and UAER (r=0.843); while negatively with HbAlc (r=-0.479), FPG (r=-0.436), 2hPG(r=-0.418),BMI (r=-0.479) and WHR (r= -0.531), all P＜0.01. Conclusions Serum adiponectin is positively correlated with UAER and negatively correlated with FPG. Blood glucose level is one of the main factors affecting serum adiponectin. Strict controlling of blood glucose level is beneficial to higher level of ADPN.

In order to study the influencing factors of clinical teaching quality,students studying in non-affiliated hospitals,clinical teachers,teaching management personnel in hospitals and university were investigated as study subjects with Delphi Method.Suggestions were put forward that non-affiliated hospitals should improve the construction of the teaching staff,emphasize the teaching management,and strengthen students' education and management for improving clinical teaching quality in non-affiliated hospitals.

The significance of strengthening the construction of teaching staff in non-affiliated hospitals was discussed. Combined with the problems in strengthening the construction of teaching staff, some countermeasures were put forward, such as emphasizing on teaching, enhancing teaching awareness, improving teaching institutions and teaching rules, selecting teaching staff with high standards, strengthening teacher's teaching ability, establishing teaching quality guarantee system and teaching stimulating mechanism.

Objective To investigate the effect of clinical pathway in health education for preventing post partum urinary retention. Methods 883 women who performed vaginal delivery in our department before implementation of clinical pathway from July to December, 2007 were set as the control group, 1172 women who performed vaginal delivery after implementation of clinical pathway were selected as the experimental group from January to June, 2008. Then the first micturition condition was compared between the two groups. Results The rate of autonomic micturition was 95.9% in the experimental group, and 91.6% in the control group, The rate of autonomic micturition was higher than that of the control group. Conclusions Application of clinical pathway to prevent post partmn urinary retention can improve obstetrical nursing quality.

Combing report of medical and health talents cultivation in a new century with the current situation of nursing education in our country,We proposed as follows:first,advocating and implementing the third generation medical education actively; Second,setting up the competency-based nursing education mode; Third,developing interdisciplinary cooperation or cooperation within discipline gradually; At last,observing nursing education from global vision.The aim was to offer references for nursing educators and nursing managers.

OBJECTIVE:To establish the quality criteria for Gengnianjingxin capsules.METHODS:The constituents of Fructus Ligustri Lucidi,Radix Polygoni Multiflori,Semen Sesami Nigrum,and Flos Albiziae etc in Gengnianjingxin capsules were identified by TLC; the content of Paeoniflorin in Gengnianjingxin capsules was determined by HPLC. The chromatographic separation was performed on a ODS-(3)C18 column with mobile phase consisted of acetonitrile-phosphate 0.1% (16∶84) at a flow rate of 1.0mL?min-1. The detection wavelength was 230nm. RESULTS:Fructus Ligustri Lucidi,Radix Polygoni Multiflori,Semen Sesami Nigrum,and Flos Albiziae were all well-separated and clear spots were noted in TLC. The calibration curve was linear for Peoniflorin in the range of 0.256 2～1.281 0?g?mL-1(r=0.999 9), with the average recovery rate of 101.86% and RSD of 1.72%(n=5),CONCLUSION:The established criteria are suitable for the quality control of Gengnianjingxin capsules.

Objective To investigate the relative factors contributing to depression and anxiety in the patients with hyperthyroidism. Methods The degrees of depression and anxiety in 141 patients with hyperthyroidism and 163 non-hyperthyroid individuals were assessed using Carrol Drpession Scale and Self-rating Anxiety Scale. The collected data were then subject to t-test, ?~2 test and partial correlation analysis. Results The incidence of depression, anxiety and both in the patients with hyperthyroidism was 66.7%, 53.1% and 42.5%, respectively, and there was a significant positive correlation between depression and anxiety (r=0.636,P

ⅳ Hydroxyl scavenger, mannitol, in the dosage of 1.1mol/L 2g/kg and 3g/kg could increase LD_(100) of ouabain on guineapigs from 298.54?33.30 ?g/kg to 367.44?44.58 ?g/kg (P