AIM: To observe and compare the antihyperlipidemia efficacy of fluvastatin vs pravasatin. METHODS: Fluvastatin group(n=41,M 22, F 19; age 60 a±s 8 a) was treated with fluvastatin 20-40 mg, po, qn for 4 wk. Pravastatin group(n=35, M 20, F 15; age 60 a±6 a) was treated with pravastatin 10 mg, po, qn for 4 wk. RESULTS: The total effective rate of fluvastatin for reducing TC was 92 %, it was higher than that of pravastatin 70 %(P＜0.05). The total effective rates of flavastatin for reducing TG and raising HDL-C were 61 % and 61 %, were similar to that of pravastatin 73 % and 69 %(P＞0.05). Adverse reactions occurred in 8 patients of fluvastatin(20 %) and in 7 patients of pravastatin(20 %), but were mild in both groups. CONCLUSION: Fluvastatin is a safe and effective antihyperlipidemic drug, and fluvastatin is more effective than pravastatin in decreasing total cholesterol.

Practical education is one of the most important ways to cultivate the medical personnel who has the ability and moral integrity at higher medical schools. To set up a long-term mechanism of practice of educating people, steps should be taken to fully understand the important sense of the times of practical education to medical students, research and construct the scientific system of practical education and protection mechanism, and to carry out diversity of evaluation and assessment.

After the connotation of collaborative innovation service was described, the difficulties for libraries to carry out collaborative innovation service were analyzed, including the unbalanced distribution of benefits, difference in its understanding , difficulties for theleading libraryto play its role, and the approaches were put forward for libraries to implement their collaborative innovation service in libraries.

Objective:To compare the value of color Doppler ultrasound(CDU),DSA,CTA and MRA in the detection of the tramatic femoral pseudoaneurysm(PA) of rabbit.Methods:Femoral pseudoaneurysms were tried established in 20 New Zealand rabbits by microsurgical technique.CDU,DSA,CTA and MRA were performed in all rabbits on 12 days after surgery and the findings of them were compared with the results of autopsy.Results:Models were made successfully in 16 rabbits.Eleven out of the 16 rabbits had developed thrombus in PA.The shown rates of the PA-body in CDU,DSA,CTA and MRA were all 100%.The shown rate of the PA-supply artery was 81.25%(13/16) in CDU and was 100% in all other three methods.The shown rates of the PA-neck were 81.25%(13/16)、87.5%(14/16)、37.50%(6/16)and 31.25%(5/16)while the shown rates of the thrombus in PA were 81.82%(9/11),18.18%(2/11),18.18%(2/11) and 36.36%(4/11) in CDU,DSA,CTA and MRA,respectively. Conclusions:Thereare no significant difference in showing the PA-body and PA-supply artery in CDU,DSA,CTA and MRA. In showing the PA-neck,CDU and DSA are superior to CTA and MRA,while CDU is superior to DSA,CTA and MRA in showing the thrombus in PA.In addition,the blood dynamic changes of PA-body,PA-neck and PA-supply artery can be studied timely by CDU,so CDU has high value in the follow up of the patient with PA.

OBJECTIVE:To prepare compound sparfloxacin auristillae and to establish its quality control method.METHODS:The auristillae was prepared with glycerin and alcohol as solvents;the contents of econazole and sparfloxacin were determined by UV spectrophotometry with their respective detection wavelengths at360nm and297nm respectively,and the stability of which were determined as well.RESULTS:The linear concentration ranges of econazole and sparfloxacin were2～400?g/ml and0.4～80?g/ml respectively;the average recovery of econazole and sparfloxacin were100.96%(RSD=0.99%)and100.38%(RSD=0.44%)respectively.The expiry date(shelf life)of the finished products was above2years.CON?CLUSION:The preparation is simple in preparation,good in stability;and the quality control method is simple and easy,rapid,accurate and feasible.

OBJECTIVE: To evaluate the curative effect of Bushen huayu tiaozhou recipe on polycystic ovary syndrome (PCOS) in plateau section. METHODS: The herbs artificial cycle method was use as main therapy. No.1 recipe used after menstrual period was as follows: nourishing the blood, reinforcing kidney, perfecting thoroughfare vessel and conception vessel; No.2 recipe used for ovulation period was as follows: reinforcing kidney and Yang, regulating Qi to dissipate blood stasis during; No.3 recipe used before menstrual period was as follows: warming Yang, reinforcing kidney, regulating Yin and Yang; No.4 recipe used for menstrual period was as follows:regulating Qi,invigorating blood circulation, dissipating blood stasis and promoting menstruation recovery.After 3 months of oral administration therapy the curative effects were observed. RESULTS: The total effective rate was 90% and the total cure rate was 40.83%. CONCLUSION: Bushen huayu tiaozhou method has satisfactory effect on PCOS in plateau section by regulating Qi, Yin, Yang and thoroughfare vessel and conception vessel to recover the regulating function of reproductive axis containing brain, kidney, thoroughfare vessel, conception vessel and uterus.

0.05). Minimum total probability are used to predict minimum sample volume which is close to overall level. Above method can be used as basic method for sample survey in regular prescription evaluation.

Using a human activated B cell line 3D5 in immunization of mouse and as targets in screening, a hybridoma producing McAb 5C5 has been established. The antigen recognized by the McAb starts its expression on low dose anti-?-activated B cells at their G_1 phase at the 10th hour. The number of 5C5~+ cells increases with time. At the stimulation of PWM, the number of 5C5~+ cells in PBMNC also increases with time, and peaks on day 3 to 4, then docreases and comes to the background on day 7.5C5 antigen is positive on the B cell lines which can not be induced to differentiate to Ig-secre-ting cells (ISC), but negative on those being able to be driven to differentiate to ISC by BCDF. All the data indicate that 5C5 expresses at the early and mid stages, but disappears at the terminal stage of B cell activation and differentiation. 5C5 antigen does not expresses on resting B cells, resting T cells, PHA-activated T cells, monocytes, neutrophils, and the T cell and myeloid cell lines detected. Electrophoresis under both the nonreducing and reducing state for the ~(125)I-label led antigen immunoprecipi tated with McAb 5C5 shows a single band with a molecular weight of 52000, suggesting that 5C5 be a single chain cell surface protein. Since the MW of 5C5 is different from that of those B cell activation antigens reported in literature, and since ins specific expression on cell lines, 5C5 antigen might be a novel B eel I-restricted activation antigen.

OBJECTIVE:To evaluate the pharmacoeconomic effectiveness of three quinolones for respiratory tract infections.METHODS:A retrospective study was conducted in which a total of 94 cases with respiratory tract infection were randomly to receive levofloxacin(Group A),ciprofloxacin(Group B) or moxifloxacin(Group C).The therapeutic effects were monitored and the cost-effectiveness analysis was performed on the three treatment schemes.RESULTS:The costs of the three groups were 397.60,1 131.90,and 2 255.40 yuan,respectively;the clinical effective rates were 73.53%,85.71% and 93.75%,respectively(P