1.Changes of serum and clinical implications of TNF-?,IL-10 and PAF in patients with acute lung injury
Journal of Chongqing Medical University 2003;0(06):-
Objective:To probe the changes of serum and clinical implications of TNF-?(tumor necrosis factors-?) of sera inflammatory cell factors and Interleukin-10(IL-10),PAF in patients with acute lung injury.Methods:The dynamic variations of serum of TNF-?,IL-10, and PAF were tested through ELISA method in 30 strictly chosen patients with acute lung injury and 30 normal people, and relativity analysis was made.Results:There was significant increase levels of TNF-?,IL-10,and PAF in patients with acute lung injury.Conclusion:Serum TNF-?,PAF,IL-10 play an important role in lung injury.This prompts three kinds of indicators have potential application value in diagnosis, treatment and prognosis of lung injury.
2.Preliminary Study on the Processing Mechanism of Cacumen Platycladi
China Pharmacist 2015;(8):1287-1289
To establish an HPLC method for the determination of myricetrin, quercitrin, myricetin, quercetin, kaempferol, amentoflavone and hinokiflavone in Cacumen Platycladi and processed Cacumen Platycladi, and compare the difference before and after the processing. Methods:The method described in Chinese pharmacopoeia was used in the processing. The chromato-graphic column was Welch Ultimate LP-C18 (250 mm × 4. 6 mm,5 μm),the mobile phase was methanol and 0. 2% phosphoric acid with gradient elution, the detection wavelength was 330 nm, and the flow rate was 1 ml·min-1 . The column temperatuhe was 35℃, the injection volume was 20μl. Results:The linear relationship respectively of myricetrin, quercitrin, myricetin, quercetin, kaempfer-ol, amentoflavone and hinokiflavone was good(r≥0. 999 0). The average recovery was within the range of 97. 6%-101. 1% (RSD≤1. 14%, n=6). The content of myricetrin, quercitrin, amentoflavone and hinokiflavone in Cacumen Platycladi was reduced after the processing, and the content of quercetin and kaempferol was increased after the processing. Conclusion: The method is simple,and can be used in the determination of Cacumen Platycladi and its processing product. The results of the content show that the flavones in Cacumen Platycladi can be changed by the processing.
3.Clinical application of basilic vein transposition arteriovenous fistula in hemodialysis patients
Clinical Medicine of China 2015;31(6):535-538
Objective To investigate the clinical effect of basilic vein transposition arteriovenous fistula in hemodialysis patients.Methods NInety patients with maintenance hemodialysis received in the NO.180 Hospital of the Chinese People's Liberation Army from September 2011 to September 2012 were randomly divided into two groups,and each group of 45 cases.Patients in the observation were given brachial-basilica transposition arteriovenous fistula,while patients in the control group received artificial vascular graft arteriovenous fistula.The fistula maturation time,dialysis blood flow,urea removal index (Kt/V),patency rates and complications were respectively recorded.Results Compared with control group,fistula maturation time,dialysis blood flow,Kt/V and complications rates in observation group were significantly higher((14.4±3.2)weeks vs.(16.1±2.7) weeks,(291.5±33.9) ml/min vs.(252.6±29.8) ml/min,(1.6±0.2) vs.(1.3±0.3);t =4.538,3.984,4.016;P< 0.05).Complications (ipsilateral upper limb swelling,thrombosis,venous ectasia and arteriovenous fistula stenosis) incidence were significantly lower than those of control group (2.2%vs.13.3%,2.2% vs.11.1%,6.6% vs.17.8%,11.1% vs.24.4%;x2=5.463,4.972,5.017,3.968;P <0.05).Patency rates of observation group in 3 months,6 months,1 year and 2 years were also significantly higher than those of control group (97.8% vs.93.3%,91.1% vs.84.4%,88.9% vs.75.6%,84.4% vs.68.9%,x2 =5.315,4.238,7.024,5.913;P<0.05).Conclusion Basilic vein transposition arteriovenous fistula is reliable and effective for hemodialysis patients.It can achieve adequate dialysis and less complications and It is worth of clinical application.
4.The clinical significance for change of serum enzyme with acute cerebral vascular disease (ACVD)
Chinese Journal of Practical Internal Medicine 2001;0(02):-
ObjectivesTo explore the clinical significant for change o f serum enzyme with ACVD.MethodsThe serum enzyme of 150 cases wi th ACVD were investigated.ResultsThe serum enzyme of 150 cases with ACVD were significantly higher than that of the control group (P
5.Advance in the research on hepatitis C virus non-structural proteins 3 protease inhibitor
Journal of Medical Postgraduates 2003;0(10):-
In view of the spread of hepatitis C virus(HCV),it still lacks an efficient anti-HCV drug or treatment until now.HCV non-structural proteins 3(NS3) protease is an important drug target in the research of the antiHCV drugs in recent years.This article reviews the active mechanism and peculiarity of HCV NS3 protease inhibitor.
6.Thinking on the clinical teaching of cardiothoracic surgery
Xiaoliang LI ; Xiaoyong XIANG ; Li CHEN
Chinese Journal of Medical Education Research 2003;0(03):-
Combined with the features of clinical practice teaching of cardiothoracic surgery ,we discuss how to improve the quality of clinical practice teaching of cardiothoracic surgery and strengthen the cultivation of medicos'capability and diathesis,thus correctly guiding medicos to finish their interim study commendably and change their roles from students to doctors.
7.Leptin and lipogenesis
Xiaoliang YANG ; Xiaolin LI ; Guohui WU
International Journal of Surgery 2008;35(3):191-193
Leptin,the product of the obese gene,is a protein produced and secreted primarily by adipose tissue.Leptin initiates several biological effects by binding to its receptors.Many studies have shown that leptin can reduce fat accumulation,but its mechanism is still unclear.This article reviewed the effects of leptin on lipogenesis,and especially on proliferation and differentiation of preadipocytes.
8.Clinical Application of Medical Ultrasonic Technique
Liwei SONG ; Xiaoliang LI ; Qing SU
Chinese Medical Equipment Journal 2004;0(08):-
The clinic main application of medical ultrasonic techniques are introduced,including ophthalmology,neurology,angiology,cardiopathy,digestive system,urology,gynaecology and obstetrics,and surgery. Four kinds of medical ultrasonic techniques in the value on the clinic diagnosis are important,namely transcranial color -coded duplex sonography(TCCD),tissue harmonic imaging(THI),three dimensional imaging(3D),and extended field Of view(EFV).
9.Effects of the Fukushima Daichi nuclear accident on children's thyroid gland
Xipeng ZHAO ; Xiaoliang LI ; Quanfu SUN
Chinese Journal of Radiological Medicine and Protection 2016;36(6):448-452
The Fukushima nuclear accident happened in 2011.This article introduced the recent studies about thyroid dose estimation,incidence of thyroid nodule,thyroid cyst and thyroid cancer in the children in Fukushima prefecture after the accident.The results suggested that the incidence of thyroid nodule and thyroid cyst had no significant increase.Nevertheless,the present research noted that the incidence of thyroid cancer was obviously higher than that in other areas in Japan,but high incidence may be due to the choice of the control group or the screening effect.Meanwhile,the contribution of 132Te to the thyroid dose and the incidence of thyroid cancer might not be ignored.The continuous monitoring before and after the operation of the nuclear power plant and the health evaculation after the accident are of importance.
10.Determination of the EC_(50) of epidural ropivacaine for analgesia in labor
Shangrong LI ; Wuhua MA ; Xiaoliang CAN
Chinese Journal of Anesthesiology 1995;0(02):-
Objective The aim of this study was to determine the effective concentration of epidural ropivacaine for analgesia in 50% of parturients (EC50) in the first stage of labor. Methods Thirty-three ASA Ⅰ - Ⅱ nulliparous women with 2-3 cm cervical dilatation who requested epidural analgesia were enrolled in the study. Epidural catheter was placed at L3-4 and advanced for 3-4 cm in the epidural space in a cephalad direction. 20 ml of ropivacaine solution of which the EC50 was being tested was given through the catheter into epidural space. The EC50 was determined by up-and-down sequential experiment. The initial concentration of the epidural ropivacaine being tested was decided to be 0.15% . If effective the next parturient received ropivacaine of a lower concentration; if ineffective the concentration of ropivacaine was increased in the next parturient. Each time the concentration of epidural ropivacaine increased/decreased by 0.01% . Analgesia was assessed by VAS score (1-10) . If VAS score was less than 3 within 30 min of ropivacaine administration, analgesia was defined as effective.Results Among the 33 parturients enrolled, three were excluded from the study because of uncertain analgesic efficacy. The results showed that the EC50 of epidural ropivacaine for analgesia in the first stage of labor was 0.063% [95% confidence interval (CI) was 0.05972%-0.06688%] .Conclusion The EC50 epidural ropivacaine for analgesia in the first stage of labor is 0.063 % determined by sequential experiment method.