The Notch receptors of mammalian include four kinds from Notch1 to Notch4.Notch ligands are divided into two families,Delta and Jagged,including Delta 1,Delta 3,Delta 4,Jaggedl and Jagged2.Notch signaling pathway is a complex network structure which is composed by receptors,ligands and downstream target genes,and it is closely related to cell proliferation,diferentiation and apoptosis.It has carcinoma suppressing or carcinogenic effects in different tissues and cells.This article mainly describes the regulation of Notch signaling pathway and its effect on children with acute leukemia.

The result of ultrasonic examination for 24 cases with adrenal tumors proved by pathology was reported.Various acoustic image features are described and the causes of errors and misdingnosis as well as the value and certain noted problems in diagnosing are analysed and discussed.A comparison is made for the data of this group with those by CT,the former showing no inferiority tO thelatter.

Objective To investigate the electrophysiological of characteristic in patients with sciatic nerve injury induced by intramuscular injection.Methods Needle electromyography(EMG) were performed on the illed lower limb muscles in 104 patients with sciatic nerve injury induced by intramuscular injection. Motor conduction velocity(MCV), distal motor latency(dML), and sensory conduction velocity(SCV) were tested on the common peroneal nerve, tibial nerve and posterior tibial nerve while recording distal compound muscle action potential amplitude(dCMAPA) and sensory nerve action potential amplitude(SNAPA) at the same time.H reflex of the low limb were examed in 21 cases.Results Multiple abnormalities of EMG and NCV were seen 2～7 days after intramuscular injection. The positive rate of NCV tests were higher in common peroneal nerve(68.0%) than in tibial nerve(43.5%)( P

Radical trachelectomy (RT) is known as a developing sign of the surgical treatment of cervical cancer in the 21st century.RT brings hope for the patients with early cervical cancer who eager to retain their fertilities.The extent of surgery include RT and pelvic lymphadenectomy.The major methods of radical trachelectomy include abdominal (RAT) and vaginal (RVT) approaches.The efficacy and feasibility of RT is similar with standard treatment,which has great application value in clinical.

Objective To establish an analytical method for fingerprint of Citri Reticulatae decoction pieces by HPLC. Methods Thermo C18 chromatographic column (4.6 mm×250 mm, 5μm) was used with methanol-0.3%phosphoric acid in gradient elution. The flow rate was 0.8 mL/min, the detection wavelength was set at 280 nm, and the temperature was 40 ℃. The similarities of the 15 batches of samples were compared by similarity evaluation, cluster analysis and principal component analysis. Results Based on the fingerprints of Citri Reticulatae decoction pieces, 8 common peaks were identified. The similarities were all more than 0.9 among all batches. 15 batches can be divided into three categories. Conclusion The method is simple and steady. It provides a basis for the quality control and evaluation of Citri Reticulatae decoction pieces.

Objective To observe the possibility and efficacy tolerability of topiramate(TPM) in transferring monotherapy for the patients wi th partial seizures with or without secondary general seizure,as well as to find out the optimum way of the transferring.Methods After T PM add-on therapy 64 patients with seizures reduced ≥50%, it reduced about 1/ 4 of AEDs or one drug each time according to every two weeks until gradually to stop fully and transferring monotherapy.Results 18 patients we re successful with TPM monotherapy (28.13%), 35 patients were half success(54.69 %), 11 cases for failure (17.19%). The less AEDs combined, the higher possibilit y of transferring monotherapy would be. The rate of success for cabamazepine see med higher than valproate.Conclusion It was possible to transfe r monotherapy by TPM. The rate of success was 28.13%. It was easier to reduce ca bamazepine than valproate. In the transferring monotherapy it was better to redu ce one after another, in principle the one of the little dose was reduced first, and then the hepatic enzyme inducing agents was reduced. Even if the transferrin g was half success,the kinds of concomitant AEDs could be reduced at least, it w as in line with the policy of medicine application.

Objective To observe the possibility and efficacy tolerability of topiramate(TPM) in transferring monotherapy for the patients with partial seizures with or without secondary general seizure,as well as to find out the optimum way of the transferring.Methods After TPM add on therapy 64 patients with seizures reduced ≥50%, it reduced about 1/4 of AEDs or one drug each time according to every two weeks until gradually to stop fully and transferring monotherapy.Results 18 patients were successful with TPM monotherapy (28.13%), 35 patients were half success(54.69%), 11 cases for failure (17.19%). The less AEDs combined, the higher possibility of transferring monotherapy would be. The rate of success for cabamazepine seemed higher than valproate.Conclusion It was possible to transfer monotherapy by TPM. The rate of success was 28.13%. It was easier to reduce cabamazepine than valproate. In the transferring monotherapy it was better to reduce one after another, in principle the one of the little dose was reduced first,and then the hepatic enzyme inducing agents was reduced. Even if the transferring was half success,the kinds of concomitant AEDs could be reduced at least, it was in line with the policy of medicine application.

Objective To observe the therapeutic efficacy and safety of Topiramate (TPM) as monotherapy in patients with partial epilepsy.Methods The seizure rate in baseline phase of 30 patients with partial epilepsy (treated by Topiramate as monotherapy for 20 weeks) were observed and recorded before treatment.The TPM starting dosage was 25 mg/d, and then increased 25 mg/d each week for 8 weeks until effective dosage or 200 mg/d for 12 weeks,the change of seizure frequency and bad reaction were found.Results The seizure in 16 cases (53.3%) was totally controlled,seizure reduction ≥75% was in 6 cases (20%),≥50% was in 2 cases (6.7%),

Objective To investigate the clinical characteristics and diagnosis and treatment of ileocecal disease.Methods The general data,clinical manifestations,imaging examinations,colonoscopy and pathological examination and diagnosis of 134 patients in our hospital with ileocecal disease from September 2009 to March 2016 were collected.The clinical characters were summarized by retrospective analysis.Results A total of 134 cases with ileocecal disease were collected,and 36(26.87％)of them were ileocecal cancer,30(22.39％)of them were inflammatory bowel disease,26(19.40％)of them were intestinal tuberculosis.The main clinical manifestations of ileocecal lesion were abdominal pain,abdominal distention,diarrhea,bloody stool,etc.The colonoscopy imaging showed mucosal hyperemia,edema,erosion,ulcer and tumors on the intestinal tract.The benign lesions mainly showed ulcer with mucosal erosion and edema,and the ileocecal cancer showed neoplasm.CT examination was the common imaging method,and 93(69.40％)cases got tested.49 cases had operation,in which 7 cases had misdiagnosed before operation,and the rate of misdiagnosis was 14.28％.Conclusion The ileocecal disease is mainly benign lesions,and the process of diagnosis is complex;the rate of misdiagnosis is a little high.

Objective:To explore the impact of continuous nursing education on the quality of life, psychological state and satisfaction of patients with inflammatory bowel disease based on micro-video.Methods:In chronological order, 83 patients with inflammatory bowel disease (hospitalized from January to June, 2019 in Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology) were divided into two groups, the control group with 42 cases (discharged from the hospital from January to March, 2019) carried out regular telephone continuing nursing education and the intervention group with 41 cases (discharged from hospital from April to June, 2019) were provided the continuous nursing education in the form of telephone plus micro-video. Before intervention and after 3 months of intervention, quality of life, levels of anxiety and depression and nursing satisfaction were evaluated by inflammatory bowel disease questionnaire (IBDQ), Self-rating Anxiety Scale(SAS), Self-rating Depression Scale(SDS), digital table method and compared between the two groups.Results:There was no significant difference in quality of life, levels of anxiety and depression before intervention between the two groups( P>0.05). After 3 months of intervention, the scores of IBDQ, SAS, SDS were 155.1±23.7, 58.7±15.1, 59.5±11.1 in the intervention group and 115.7±21.7, 71.5±16.7, 72.8±12.0 in the control group, the differences between the two groups were statistically significant ( t values were 7.910, 3.642, 5.223, P<0.01). The nursing satisfaction score was 89.32±6.34 in the intervention group and 81.45±7.21 in the control group, the difference between the two groups was statistically significant ( t value was -5.284, P<0.01). Conclusions:Continuous nursing education in the form of micro-videos can increase the quality of life of the inflammatory bowel disease patients, improve mental state and their nursing satisfaction in further.