The Notch receptors of mammalian include four kinds from Notch1 to Notch4.Notch ligands are divided into two families,Delta and Jagged,including Delta 1,Delta 3,Delta 4,Jaggedl and Jagged2.Notch signaling pathway is a complex network structure which is composed by receptors,ligands and downstream target genes,and it is closely related to cell proliferation,diferentiation and apoptosis.It has carcinoma suppressing or carcinogenic effects in different tissues and cells.This article mainly describes the regulation of Notch signaling pathway and its effect on children with acute leukemia.

AIM: To verify the protection of astragalus polysaecharide (APS) on H2O2 - stressed skin fibro-blasts. METHODS: A model of acute H2O2 stress in primary skin fibroblast was used at concentration of 0.5 mmol/L by 30 rain incubation. Dose responses of APS on cell survival was measured by MTI, cell death was evaluated by DAPI, and effect of APS on mitochondria, mitochondrial membrane potential and lysesome stabilization were measured by confocal microscopy. RESULTS: APS improved cell survival in a dose -dependent manner, starting at 0. 5 mg/L and with a maximum at 1 mg/L. Moreover, APS inhibited mitochondrial membrane potential collapse, protected mitechondrial morphology and stablized lysosomal membrane. CONCLUSION: The results suggest the existence, at the mitochondria-lysosome level, of a new pathway of apoptotic regulation by APS. This might constitute a new therapeutic target where oxidative stress and lysesomal impairment are involved.

Objective To explore the clinical value of intravenous thrombolysis in the treatment of patients with acute myocardial infarction (AMI) and cardiac arrest after cardiopulmonary resuscitation.Methods 120 patients with AMI and cardiac arrest admitted in our hospital from Mar 2009 to Mar 2013 were divided into thrombolytic group (n=50) and control group (n=70) according to the voluntary principle.The recanalization rate,return time of spontaneous circulation,left ventricular ejection fraction (LVEF) and creatine kinase-MB (CK-MB),complications and hospital mortality rate were compared between two groups.Results The recanalization rate was significantly higher in thrombolytic group than in control group (76％ vs.11.4％,x2 =84.81,P＜ 0.05).Restoration of spontaneous circulation was significantly shorter and LVEF after one week of treatment and CK-MB peak were significantly higher in thrombolytic group than in the control group (t=6.796,4.342,2.923,respectively,P＜0.001 or 0.05).The incidences of heart failure,angina,arrhythmia,and re-infarction were significantly lower in thrombolytic group than in control group (x2 =6.10,20.95,8.52,11.10,respectively,all P＜0.05).There were no significant differences in the incidences of intracranial hemorrhage and upper gastrointestinal bleeding between thrombolytic group and control group (x2 =2.19,3.74,both P＞0.05).Hospital mortality rate was significantly lower in thrombolytic group than in control group (10 ％ vs.25.7 ％,x2 =4.65,P＜0.05).Conclusions Intravenous thrombolysis has a higher recanalization rate,faster recovery time of spontaneous circulation,fewer complications and higher hospital survival rate for the treatment of cardiac arrest in patients with acute myocardial infarction after cardiopulmonary resuscitation.

Objective To analyze nursing risk factors in digesting internal medicine nurses,looking for effective prevention measures and observe the nursing effect. Methods Nursing risk factors were analyzed from November 2009 to October 2010,and effective preventive measures were explored and applied from November 2010 to October 2011.The incidence rate of nursing accidents,the degree of satisfaction and approval,and basic nursing quality were compared before and after the implementation of nursing risk preventive measures. Results Nursing accident before and after the implementation was 0.98％ and 0.12％,the degree of satisfaction and approval before and after the implementation was 78％ and 75％,the basic nursing quality score before and after the implementation was (93.87 ±1.26)points,(99.68 ±0.54)points,the results before and after the implementation showed significant difference. Conclusions To adopt effective nursing risk preventive measures can significantly reduce the incidence of nursing risk,improve nursing service quality and satisfaction degree of patients.

Objective To study the effects of evidence-based nursing in improving life quality and emotional situation of patients with gastric cancer during perioperation. Methods 96 patients with gastric cancer in our hospital from October 2007 to November 2010 were selected as research object,and all the patients were randomly divided into the control group and the observation group with 48 cases in each group,then the compliance therapy,degree of satisfaction, Kamofsky score,spitzer score, SAS score,SDS score,HAMA score and HAMD score of the two groups before and after surgery on the first,seventh day and first month were analyzed and compared. Results The compliance therapy and degree of satisfaction of the observation group were both better than those of the control group,the Karnofsky score and spitzer score of the observation group after surgery on the first, seventh day and first month were higher than those of the control group,SAS score,SDS score,HAMA score and HAMD score of the observation group were better than those of the control group. Conclusions The effects of evidence-based nursing in improving life quality and emotion situation of the patients with gastric cancer during perioperation is better,and it is worthy of popularization and application.

It is inevitable that the construction of urban and rural medical security system is the law of economic and social development,but there are still more constraints in this social system engineering.Deep analysis and research were carried out from six aspects in this paper such as the constraints of traditional thought and economy,obstruction of the existing household registration system,constraints of the existing land system,legal obstacles and institutional barriers; and ways to solve the problems were trying to be found in order to methods for the construction of the urban and rural medical security system in our country.

Implementing PBL teaching in the political theory course,making sure the scientific nature of the problem setting are the fundamental guarantees of the right track of political theory education.There are several specific approaches to implement the PBL teaching effectively:leading up to the problem when teacheing in the large class; completing the analysis and research by dividing groups; carrying out class discussions by teams; submitting discussion experiences by each student.Practice has proved that,PBL teaching is better than LBL one.

Food allergy ( FA ) often leads to protracted diarrhea and chronic diarrhea, which influence children′s nutrition and growth seriously and early diagnosis and treatment is particularly important. Its pathogenesis includes IgE mediated,not IgE mediated,and mix. Mainly manifestations include:food protein mediated rectum colitis, food proteins mediated enterocolitis syndrome,food proteins mediated bowel disease,and coeliac disease ( CD) . Diagnosis should be asked for details of the history. Diet avoidance and open food challenge tests help determine the diagnosis. Treatment mainly for suspicious foods to avoid,breastfeeding should be continue,mothers need to avoid food allergies, artificial feeding should be changed to extensively hydrolysed protein formula( eHF) or amino acid-based formula( AAF) feeding. Try not to use of antibiotics,and to give support therapy. Early diagnosis and treatment,correct nutritional gui-dance can prevent serious complications,reduce its incidence.

This paper reports one case of Gongylonema pulchrum infection in the esophagus in human.

Problems in pathology teaching requires the introduction of PBL pedagogy.Teaching experiments show that PBL teaching has a positive impact on the improvement of clinical medical students'ability and quality and can be conditionally applied and promoted. And at the same time, it is a challenge to traditional teaching mode of pathology and therefore the reform of medical education needs to be deepened.