Gastric cancer is a malignant tumor with high incidence and mortality in China.Invasion and metastasis of carcinotissue is one of the main reasons for the death of patients with gastric cancer.The mechanism of gastric cancer invasion and metastasis is very complicated,containing several immunomolecules and genes.Up-or down-regulated expression of these molecules in gastric cancer invasion and metastasis means that these immunomolecules and genes play some important roles in generation and progression of gastric cancer.In this review,we introduced the structure and function of these immunomolecules and genes,and their action during the course of gastric cancer invasion and metastasis.

Objective To carry out the performance evaluation to insure security of inner canister during the design phase, which is the important thin component of the portable sterilizater. Methods The software Mechanica, one of the module of Pro/Engineer was implemented to the flexure analysis of the inner canister. Results The stabilization and strength of inner canister satisfied requirements of the design. Conclusion Not only the security of design data can be proved but the cost and cycle of design can be reduced by using the method of expansion simulation analysis at the same time of the design phase of the equipment.

Small ubiquitin-like modifiers(SUMO) are ubiquitin-related proteins that can be covalently conjugated to cellular target proteins.Frequently,this modification has a key role in regulating the activities of those targets and,hence,their cellular functions.Researches show that some oncoproteins,tumor suppressors,DNA repair proteins and cyclins are target proteins of SUMO modification and the altered expression of some enzymes related to SUMO conjugation occurs in some neoplasm.It is indicated that sumoylation is important in tumor origination,development and metastasis.

OBJECTIVE:To improve the medication compliance of diabetic patients.METHODS:A questionnaire survey was conducted on the spot with Excel used for data input,and the data were analyzed statistically using chi-square test in SPSS13.0 software.RESULTS & CONCLUSION:The medication compliance rate of the 193 diabetic patients was low at 47.15%.The diabtes patients' medication compliance can be improved through regular consultation,recognition of disease,knowledge on drugs and better pharmaceutical care.

BACKGROUND:It is difficult to expose bilateral facet joints in L5 spondylolysis patients compared with non-spondylolysis patients. Thus, vertebral facet joint spacing and height in L5 spondylolysis patients can be used as indirect diagnostic signs that play key roles in the diagnosis of spondylolysis.
OBJECTIVE:To analyze the ratio of vertebral facet joint spacing and height in L5 spondylolytic vertebra and the relationship between the lumbar spondylolysis and the relative spacing of articular process.
METHODS:(1) Analysis of anatomical structure characteristics and diagnostic methods of lumbar spondylolysis:The ratio of vertebral facet joint spacing and height in L5 spondylolytic vertebra in diagnosing feasibility of lumbar spondylolysis was analyzed. (2) A total of 23 patients with L5 spondylolysis from Department of Orthopedics, Puyang Oilfield General Hospital and 30 normal controls were col ected from April 2013 to February 2015. The ratio of vertebral facet joint spacing and height in L5 spondylolytic vertebra was measured between the two groups.
RESULTS AND CONCLUSION:(1) The ratio of vertebral facet joint spacing and height in L5 spondylolytic vertebra reflected that the occurrence of L5 spondylolysis was probably associated with the width of L5 vertebral facet joint spacing. (2) Clinical trial results showed that the ratio of vertebral facet joint spacing and height in L5 spondylolytic vertebra in L5 spondylolysis patients was higher than normal controls. (3) Results indicate that the ratio of vertebral facet joint spacing and height in L5 spondylolytic vertebra reflects the occurrence of L5 spondylolysis.

Objective To investigate the relationship between the expression of metastasis associated antigen 1 (MTA1) and the biological behavior of endometrial carcinoma. Methods From May 2005 to May 2007, 30 patients with endometrial carcinoma and 20 patients with normal endometrial tissues, were admitted to Changzheng Hospital of the Second Military Medical University for surgical treatment were involved in the present study. The expression of MAT1 mRNA in two different groups was detected by real-time RT-PCR, and of MAT1 protein was detected by immunohistochemical streptavidin-peroxidase (SP) method and Western blotting. The relationship between their expression and pathological features were analyzed. Results The positive expression rate of MTA1 protein was 80% in endometrial carcinoma group, which was significantly higher than that in control group (30%, P0.05). Conclusion The expression of MTA1 might play a potential role in the pathogenesis and development of endometrial carcinoma, and it might be a novel target for the therapy and prognostic indicator of endometrial carcinoma.

OBJECTIVE To evaluate the role of real-time fluorescent quantitative PCR assay in the early diagnosis of invasive aspergillosisi(IA) after allo-hematopoietic stem cell transplantation.METHODS All 123 serum samples from 18 IA patients and 38 no-invasive fungal infection(IFI) patients were detected by TaqMan-based real-time PCR to explore the cutoff of this array,while the primer and probe could amplificate five major Aspergillus species including A.fumigatus,A.flavus,A.niger,A.terreus and A.oryzae.RESULTS The optimal value could be acheived while the cutoff was set as two or more consecutive sample DNA≥15pg/?l in a week,and the sensitivity and specificity was 94.4% and 100.0%,respectively.CONCLUSIONS Real-time fluorescent quantitative PCR is helpful in early diagnosis of invasive aspergillosis.

This paper introduces the surgeon backpack and medical corpsman backpack which are newly developed for PLA.The twokinds of backpacks being waterproof,water can't penetrate intothem when they are in the rain or floating on water.The basic performance experiments,ergonomics tests and army tryout are performed.The results show that the backpacks are designed reasonably and easy touse.The burthen on the whole backpacks is distributed in the equipment uniformly due toits structure.The physical energy consumption of the person carrying the backpacks decreases due tothe same reason.The medical equipments in the backpacks can accomplish the first aid operations such as binding up,stanching,acesodyne,fastness,ventilation,infection prevention and anti-shock.

Objective To assess the effect of Ambroxol combined with Naloxone on respiratory insufficiency on premature infants. Methods A total of 168 premature infants treated from 2006 to 2009 in our hospital were divided into two groups randomly. Additionally to the conventional treatment, Ambroxol (5 mg pertime) combined with Naloxone (0.1mg pertime) intravenously injected 2 to 3 times one day for 3 to 5 days in the treatment group(86 cases). The control group (82 cases) was treated by routine Aminophylline injection,3- 5 mg/kg pertime, 2 to 3 times one day. Respiratory rates, regulately or not,breathholding, cyanosis and apnea,mechanically ventilated time,time of oxygen inhaling, time of hospital stay and the overall response rate were measured. Results The overall response rate was 80% (69/86) in the treatment group and 56% (46/82)in the control group, with significant difference between the two groups ( P ＜ 0. 05 ). Mechanically ventilated time,time of oxygen inhaling and hospital stay in the treatment group was (110.5±45.1) hrs, (169.3±58.6) hrs and ( 12±3) days, which were all significantly lower than that in the control group ( 181.1±81.2) hrs, (236.6±87.8)hrs and (16±5)days,respectively(P＜0.01 or 0.05). Conclusion Ambroxol and Naloxobe additional to conventional treatment could improve the respiratory function in premature infants with respiratory insufficiency safely with less side effects. Moreover,breathing machine could be removed to some extent,which made it more applicable in primary hospitals.

OBJECTIVE:To establish a method for the determination of the dissolution rates of azithromycin tablets and to compare the dissolution rates among azithromycin tablets that from different manufacturers so as to provide references for clinical medication.METHODS:The concentrations and drug cumulative dissolution rates of a total of 5 batch numbers' azithromycin tablets that from 5 pharmaceutical factories were determined based on the related standard procedure indexed in China Pharmacopoeia(2005 edition),then the dissolution parameters were calculated with Weibull formula.RESULTS:The dissolution rates at 45 min were above 75%,which was up to the standard.The analysis of variance showed that there were significant differences among samples in dissolution parameters(P