al recovery. Therefore, EPC may have broad application prospects in the field of ischemic cerebrovascular disease.

With the emergence of new concepts, methods and techniques in modern medicine, the basic research and clinical treatment for gynecological oncology has rapidly developed in the past couple of years. Evidence-based medicine, individualized therapy and microinvasive therapy give us more opportunities to treat the patient. Nowadays, it is possible for the clinic to implement new approaches to improve the outcome and the quality of life for the patients with minimal side effects at the same time. There has been a lot of reports from in vitro studies suggesting that gonadotrophin may play an important role in tumorigenesis, estrogen may promote tumor cell proliferation through PAX2 gene. Survivin, a protein serving as an apoptosis inhibitor, may be crucial for the regulation of tumor cell proliferation and apoptosis.

Objective:To evaluate the effect of agar-oliogsaccharides (mainly containing agarobiose) on blood glucose level and oxidation-antioxidation status in alloxan-induced diabetic mice. Method: The inhibitory activity of agarobiose on ?-glucosidase was investigated. Alloxan was used to establish non-obese diabetic (NOD) mice model. After 14 d administration of agarobiose, blood glucose, MDA, SOD, GSH and GSH-Px levels were determined. Results:Agarobiose showed inhibitory activity on ?-glucosidase with IC50=1.39 mg/ml, Ki=0.52 mg/ml. In a certain concentration (200-400 mg/kg bw), agaro-oligosaccha- rides reduced the blood glucose level remarkably, and the oxidative indices were also improved in heart, liver, lung and brain. The blood glucose level (P

Objective To compare heparin binding protein (HBP)and procalcitonin(PCT)in the evalua-tion of in prognosis of patients with sepsis in ICU.Methods 80 sepsis patients were selected.According to the sever-ity of the disease,they were divided into general sepsis group (n =31),severe sepsis group (n =29)and death group (n =20).The differences of HBP and PCT in three groups were compared.Results Compared with HBP and PCT in the general sepsis group[(3.91 ±0.36)ng/mL,(1.26 ±0.35)ng/mL)],PCT of the severe sepsis group (11.81 ± 0.54)ng/mL was significantly increased(F =2 777.87,P =0.000);HBP and PCT of the death group[(15.28 ± 1.21 )ng/mL,(36.68 ±0.36)ng/mL)]were significantly increased compared with the general sepsis and severe sep-sis groups (F =49 789.02,P =0.000).Conclusion The sensitivity of PCT was significantly higher than HBP in the groups,PCT was better in judging the prognosis of sepsis.

Objective The purpose of the study was to investigate the causes of hemoptysis and ex-plore the diagnostic procedures for hemoptysis in children. Methods The medical records of 42 children with hemoptysis admitted to the Respiratory Department of Hunan Children′s Hospital from June 2012 to June 2015 were collected by a retrospective study. The causes of hemoptysis were classified by pathogenesis,and the diagnosis of hemoptysis was evaluated in this study. The final diagnosis was divided into clear diagnosis and the cause was unknown. Results A total of 41(97. 6%) cases were diagnosed,1(2. 4%) case was not diagnosed. In 42 cases of hemoptysis,infection was the main cause of the disease,including 8(19. 0%) cases of pneumonia and 5(11. 9%) cases of bronchitis,and the following causes were bronchial artery fistula(10/42,23. 8%),idiopathic pulmonary hemosiderosis(8/42,19. 0%),bronchiectasis(5/42,11. 9%),pulmonary vascular malformation with pulmonary hypertension(3/42,7. 2%),pulmonary tuberculosis(2. 4%),bronchi-al foreign body(1/42,2. 4%) respectively. Thirteen cases of respiratory tract infection,and 5 cases of bron-chiectasis were diagnosed by chest CT,10 cases with pulmonary artery fistula were diagnosed by digital sub-traction angiography,8 cases of pulmonary hemosiderosis,1 case of pulmonary tuberculosis,and 1 case with bronchial foreign body were diagnosed by fiberoptic bronchoscopy. Three cases of pulmonary vascular malfor-mation and pulmonary hypertension were diagnosed by row helical CT angiography and cardiac color ultra-sound. Conclusion Hemoptysis in children is a heterogeneous group of respiratory disorders. Most causes could be identified by using the diagnostic procedures. Other factors, including medical history, CT, fiber bronchoscopy,multidetector CT angiography, cardiac color ultrasound and digital subtraction angiography, play important roles in the diagnosis of hemoptysis in children.

Objective To analyze the epidemical distribution of intestinal nematode infections in Jiangsu Province in recent 30 years,so as to provide the evidence for improving prevention and control of intestinal nematodiasis in the future. Methods The literature related to intestinal nematode infections in Jiangsu Province from 1984 to 2012 was searched and the infection data in them were sorted and analyzed. Results A total of 26 papers were obtained. In the recent 30 years,the infection rates of Trich-uris trichiura,Ascaris lumbricoides and hookworm in Jiangsu Province decreased gradually,but the infection levels in northern Ji-angsu were higher than those in central and southern Jiangsu. In northern and central of Jiangsu Province,the descent speed of the intestinal nematode infection levels was faster before 2000,and then it slowed down after 2000. In southern Jiangsu,the descent speed of the infection level of A. lumbricoides was the fastest,but the infection level of T. trichiura with slight fluctuation kept rela-tively steady. From 1984 to 1989,the infection rates of the 3 intestinal nematodes above-mentioned in all age groups were high, and those of T. trichiura and A. lumbricoides were above 20%and 30%,respectively,and the infection rates of hookworm in mid-dle aged and elderly populations were relatively high. From 1990 to 2000,the infection rates of A. lumbricoides in children and teenager as well as that of hookworm in the people aged from 40 to 70 years were high,but those of T. trichiura and A. lumbricoides in the people above 70 years old were low. During the period of 2001 to 2012,the middle aged and elderly population and children were still the high-risk groups of hookworm and A. lumbricoides infections,respectively. Conclusions In the recent 30 years,the infection rates of intestinal nematodes in Jiangsu Province have decreased year by year,but the infection levels in northern Jiangsu are still higher than those in central and southern Jiangsu,which means that the northern Jiangsu is the key area of intestinal nema-todiasis control. Meanwhile,the A. lumbricoides infection rate of children and T. trichiura infection rate of the middle aged and el-derly population are high,which suggests that the control should put emphasis on the key population.

Tumor is a reciprocity result of various genes and factors,and its incidence and mortality remain high.Such traditional strategies as surgery,radiotherapy and chemotherapy cannot completely restrain and reverse the growth of tumor cells.So,new and more effective therapeutic methods are being expected.This article updates the development of RNA interfering(RANi) technique in the targeting therapy of the tumor gene.

With the change of modern medical model and the rapid development of medical technology,medical humanities education in higher medical education has obviously been weakened and has obvious deficiencies.We should fully understand the importance and the necessity of medical humanities education during cultivating medical students.We should also improve medical humanities curriculum system,construct teaching staff combining with different majors,intensify the cultivation of humanistic quality in practice and organically combine ideological and political with humanistic education,and perfect evaluation system,etc.Inall We should explore the effective way of medical humanities education in many aspects.

s: Gastric carcinoma is the most common malignant tumor in China. When exposed to the same susceptible factor, different people have different incidence. Recent studies revealed that it may be related to some genes' polymorphism. In this article, the polymorphism of metabolism enzyme gene, oncogene, anti-oncogene, immune factor gene, pepsinogen C gene and mucin gene are reviewed. We highlight the situation of gastric carcinoma with some susceptible genetypes, also the possibility of using them to help scanning.

Objective To identify the genetic mutation of the gene FOXL2 in a big Chinese family with 4 generations,8 patients and 11 health members which have blepharophimosis-ptosis-epicanthus-inversus syndrome(BPES) type Ⅰassociated with ovarian dysfunction,and demonstrate the correlation between clinical phenotype and genotype.Methods The peripheral blood samples,with 5ml EDTA as decoagulant,from 8 patients and 11 health people in a big Chinese family affected with BPES typeⅠwere collected.The genomic DNA from peripheral blood leukocytes was extracted.7 pairs of primers were designed by the Oligo6 according to the sequence of the FOXL2 gene(GenBank ID AF301906).The exons and the putative core promoter of the FOXL2 gene were amplified using polymerase chain reaction(PCR),and mutation was analyzed by sequencing DNA fragments.Results A novel nonsense mutation at nucleotides in the FOXL2 gene was found in the eight affected patients of the big Chinese family with BPES typeⅠ.No mutation was found in any of the health members in the big Chinese family.Conclusion This is the first reported mutation of the FOXL2 gene in a big Chinese family with BPES typeⅠ.This nonsense mutation in the FOXL2 gene may be an important pathogenesis for the BPES typeⅠin this big Chinese family.It is the first time that a novel nonsense mutation in the FOXL2 gene has ever been found to demonstrate a close correlation between genotype and BPES typeⅠ.