FOXM1 is a member of the FOX family of transcription factors and has been confirmed to participate in cell prolifera-tion and cell cycle progress. FOXM1 has been reported to play an important role in more than 20 types of human neoplasms, and its up-regulation promotes tumor cell proliferation, invasion, metastasis, chemotherapy drug resistance, and resistance to apoptosis. In recent years, various studies have shown that FOXM1 also plays an important role in tumor metabolism. The metabolism of cancer cells deter-mines the growth and survival of cancer, and metabolic alteration is a key feature of tumor cells. The connection between metabolic ab-normalities and tumorigenesis has been reported. The O-linkedβ-N-acetylglucosamine transferase regulates the expression of FOXM1, which helps tumor cells survive without damage caused by oxidative stress. This review aims to summarize the known relationships of FOXM1 and tumor cell metabolism, as well as its role in the potential pathways of tumor metabolism.

Objective To observe the therapeutic effect of modified Buyang Huanwu decoction combined with betahistine hydrochloride in the treatment of vertebral-basilar artery ischemic vertigo and its influence on hemorheological index.Methods 80 patients with vertebral-basilar artery ischemic vertigo were randomly divided into observation group and control group,40 cases in each group.The control group was given betahistine hydrochloride 12 mg,three times a day.The observation group was given modified Buyang Huanwu decoction on the basis of the control group, 4 weeks for a course.The DARS and DHI were measured before and after 4 weeks of treatment.The blood flow velocity was detected by transcranial Doppler ultrasonography, the difference of clinical curative effect between the two groups was compared.Results After treatment, the DARS and DHI scores of the observation group and control group were significantly decreased(t=14.716 and 5.258,20.662 and 14.609,all P<0.01).The DARS and DHI scores in the observation group were significantly lower than those in the control group (t=3.644,7.116,all P<0.05).After treatment,the average blood flow velocity of the vertebral artery, right vertebral artery and basilar artery in the observation group and the control group were significantly increased(t=11.216 and 7.447,10.103 and 7.204,11.303 and 6.642,all P<0.01).The average blood flow velocity of the vertebral artery, right vertebral artery and basilar artery in the observation group were significantly higher than those of the control group (t=4.405,4.761,5.824,all P<0.01).The total effective rate of the observation group was 95.00% (38/40),which was significantly higher than that of the control group (77.50%,31/40), the difference was statistically significant (Z=-2.000,P<0.05).Conclusion Modified Buyang Huanwu decoction combined with betahistine hydrochloride is effective in the treatment of vertebro-basilar ischemic vertigo.It can improve the blood supply to the brain and relieve the symptoms of vertigo, which is worthy of popularization and application.

OBJECTIVE To investigate the situation of the tumor patients with subsequent bacteremia in hospital in order to study the some prevention and controlling measures. METHODS Ten cases in the internal medical department for tumor with the central venous pressure apparatus were analyzed and had the symptom of chilling and hyperpyrexia , and then were carried through the germiculture for the central venous catheter. RESULTS Pathogenic microorganism had been isolated from the hemoculture. CONCLUSIONS Once the patients with the central venous pressure apparatus have the symptoms of unknown infection, it must be consider the possibility of contaminated tube and conduct countermeasures in time.

Carcinoma ; Humans ; Male ; Middle Aged ; Parathyroid Neoplasms

Objective To explore the application effects of online tests through two-dimensional code in the course of Fundamental Nursing. Methods A total of 79 nursing students in 2016 were included in the study. Compared with traditional method in the first term, online tests through two-dimensional code were implemented in the second term. The students′ appraisal on online tests through two-dimensional code was investigated with a self-designed questionnaire. Results The students showed a positive attitude to online tests through two-dimensional code. 97.3%(71/73) of the students thought online tests through two-dimensional code was easy to implement, and 93.2%(68/73) of them agreed that online tests help them to know how they learned and improved the efficiency and quality of class. Conclusions Online tests through two-dimensional code, which are novel, energy-saving and environmental friendly,can improve students′learning interest and enhance learning effect.Therefore,it is worthy to be applied and recommended.

Objective To find out some trigger factors for the onset of acute childhood leukemia by examining seasonal distribution through a small cohort study in a single center.Methods The records of 688 childhood patients(age≤15 years)whom were initially diagnosed at Blood Disease Hospital of CAMS from October 2003 to June 2006,were retrospectively analyzed.Results In terms of time,our study provides modest support for sessonal peaks in summer and winter,or in Jan & Jun.Conclusion We initially realized the season tendency of the onset of acute childhood leukemia in some northern parts of China.which suggest that childhood acute leukemia is associated with the infection.

Biopartitioning micellar chromatography (BMC) is a potentially high throughput and low cost alternative for in vitro prediction of drug absorption, which can mimic the drug partitioning process in biological systems. In this paper, a data set of 56 compounds representing acidic, basic, neutral and amphoteric drugs from various structure classes with human oral absorption (HOA) data available were employed to show the effect of acidity of drugs in oral absorption prediction. HOA was reciprocally correlated to the negative value of the capacity factor (kBMC) determined by BMC at pH 7.4 and 6.5. The relationships between kBMC and the corresponding HOA values of all compounds were rather poor, but the correlations were improved when the acidity of drugs was taken into consideration. Moreover, the proposed models allowed obtaining of good predictive values for both highly and poorly absorbed compounds. It is demonstrated that the constructed models derived from compounds with the same kind of charge property are of more practically meaningful and rigorous.

Objective To observe the antibacterial effects of amikacin sulfate combined with the ingredient of coptis chinensis:the extract of coptis chinensis, berberine hydrochloride and palmatine hydrochloride on multiple drug resistance (MDR) of Escherichia coli (E.coli) in vitro. Methods One hundred strains of E.coli checked out from 2013 to 2014 that showed resistence to cefotaxime were selected, and in which MDR to bacteria were determined. The extended-spectrum β-lactamases (ESBLs)-producing by Kirby-Bauer test. The minimum inhibitory concentrations (MIC) of the extract of coptis chinensis, berberine hydrochloride, palmatine hydrochloride and amikacin sulfate on ESBLs-producing E.coli were determined firstly, and then the sterilization effects of amikacin sulfate combined with the other three medicines were observed by broth microdilution checkerboard method together with their fractional inhibitory concentrations (FIC), with ATCC 25922 for quality control strains. Results Ten MDR E.coli were screened and proved to be ESBLs-producing. The inhibitory effects were enhanced in a synergistic or additive pattern when amikacin sulfate combined with the extract of coptis chinensis, berberine hydrochloride on nine of the ten MDR E.coli in vitro, where the inhibitory effects were a synergistic or additive pattern when amikacin sulfate combined with palmatine hydrochloride on all of the MDR E.coli in vitro. Conclusion Palmatine hydrochloride or berberine hydrochloride or the extract of coptis chinensis combined with the amikacin sulfate has significant value in treatment of MDR E.coli, which is worthy of further study.

Objective To explore the anti-infection mechanism of carboxyamidotriazole (CAI) through studying the effects of CAI on the proliferation, apoptosis and degranulation of RBL-2H3 mass cells.Methods Compound 48/80 (C48/80) was used to induce the model of activation and degranulation in RBL-2H3 cells.The morphological change of cell degranulation was observed by neutral red staining.The release levels of histamine and β-hexosaminidase were measured by ELISA method and chromogenic assay, respectively.The cell activity was determined by CCK-8 method.And cell apoptosis was detected by Hoechst 33342 fluorescent staining.Results Compared with the control group, 10, 20, 40 μmol/L CAI inhibited C48/80-induced degranulation of RBL-2H3 cells in different degrees.CAI (20, 40 μmol/L) reduced the histamine release (P<0.01), and CAI (40 μmol/L) decreased the β-hexosaminidase release (P<0.01).In addition, the viability and apoptosis of RBL-2H3 cells were not affected at the concentrations of CAI used.Conclusions CAI can effectively inhibit the activation and degranulation of RBL-2H3 mast cells, and this effect is not through cytotoxicity.The anti-infection effect of CAI may partially due to the down-regulation of mast cell activity.

[Objective] To observe the effects of Tongbiling (TBL) prescription in counteracting cartilage destruction in rats with rheumatoid arthritis (RA). [Methods] Collagen-induced arthritis (CIA) rat models were established to observe the therapeutic effects of TBL. After a short-term treatment, expressions of tumor necrosis factor (TNF - a) and transforming growth factor (TGF- P) in cartilage tissue of model group, methotrenxate (MTX) tablets group and Radix Tripterygii Wilfordii (RTW) preparation group were examined by immunohistochemical semi-quantitative assessment method. [ Results ] The number of chondrocytes with positive TNF - a expression was lower and the chondrocytes were stained lighter in normal group than those in model group and low-dose MTX group ( P