Wnt signaling pathways is a hot focus in recent years,which plays important regulatory roles in cell proliferation,differentiation and migration.Wnt signaling pathways include classical Wnt signaling pathways and non classical Wnt signaling pathways.Wnt11 is a very important signal molecule in the nonclassical WNT signaling pathways and kidney development,which plays a positive regulatory effect in the development of kidney and become silent in mature kidney.Studies have shown that Wnt11 re-express in the renal fibrosis.This paper discusses the function of the Wnt11 in kidney development and the relationship between Wnt11 and renal fibrosis.

Objective To summarize nursing measures of one liver cancer patient with hand-foot syndrome by onral intake of Nexavar. Methods Care focused on close observation of disease condition changes,strengthening skin care,psychological support,life care,health education and dietary care. Results The patient was discharged crred after two-week treatment.Through intensive care,the patient was discharged from hospital after 2 weeks. Conclusions To teach patients self-observation and prevention measures of hand-foot syndrome can ensure early detection,early treatment and early recovery of them.

Chronic Disease ; Elasticity Imaging Techniques ; Humans ; Liver Diseases ; diagnostic imaging

Objective To study the applied value of MR DWI and ADC value of in the hepatic lesions.Methods 36 cases ofhepatocellular carcinoma,15 cases of metastases,33 cases of hepatic cavemous hemangioma and 12 cases of cyst were examined by DWI andconventional MRI,then the ADC values were measured.Results The average ADC values of hepatic lesions were as follows:cyst was(2.90?0.68)?10~(-3)mm~2/s,hemangioma was(2.01?0.53)?10~(-3)mm~2/s,metastases was(1.57?0.42)?10~(-3)mm~2/s,hepatocellular carcinoma was(1.20?0.32)?10~(-3)mm~2/s.The ADC values of benign lesions were higher than those of malignant(P

Regulatory T cells are a group of subgroup T cells with special immune regulating function,which participate in keeping immune homeostasis and play important roles in preventing autoimmune diseases.However,regulatory T cells also promote tumor immune evasion.The highly increase of its expression will significantly reduce the smvival rate of cancer patients.Gastric cancer with high mortality is difficult to detect in early stage.China is one of the high-prevalence gastric cancer countrys.This article mainly introduced the sources,classification and immune phenotype of regulatory T cells and its function mechanism to explore its relationship with gastric cancer in order to discover the new strategy of tumor immunotherapy.

0.05).Conclusion:Balofloxacin is as effective and well-tolerated as levofloxacin for the treatment of bacterial infections in urinary system respiratory tract.

Objective:To investigate the changing characteristics of neural stem cells(NSC) in the temporal lobe of cortex from human fetal brain at different age.Methods:Ninety embryos delivered by induction labor with water bag at gestational age 16-36 w were collected,distribution,Shapes,growth modes and the number of NSC in the temporal lobe of cortex were determined with immunohistochemical method under light microscope. Results:NSC existed in the temporal lobe of cortex from human fetal brain and were round,elliptic or polygonal in shape,especially small round,NSC distributed mainly in cone cell and inner granule cell layers.NSC had enations from 0 to 2,nucleoli from 1 to 2 and rarefactive chromatin,nucli were large.Most NSC distributed in clones with a few NSC existed in a single mode among other nerve cells.There were no differences between groups in the distribution,shapes,species and growth modes of NSC in the temporal lobe of cortex,but the numbers of NSC gradually decreased with increase of age.Conclusion:There were no differences on the distribution,shapes,species and growth modes of NSCs in the temporal lobe of cortex from different gestational age,the number of NSC decreased with increase of age.

Objective: To explore the clinical research on the treatment of osteoporosis with calcitonin and Low frequency pulse electromagnetic field. Methods:Selected 84 cases of primary osteoporosis were randomly divided into control group and treatment group, 42 cases in each group, two groups were given calcium, vitamin D and other drugs conventional treatment, on the basis of the control group, intramuscular injections salmon calcitonin in the treatment group and intramuscular injection of salmon calcitonin with PEMF therapy, before treatment and after 3 and 6 months, respectively. Results: Two groups of patients after treatment, the pain was significantly reduced compared with before treatment, the longer the treatment, the more obvious decline;Treatment of three months, six months later, the treatment group compared with the control group bone mineral density were significant differences(t=3.129, t=6.457;P<0.05);The two groups no serious adverse reactions. Conclusion:Osteoporosis patients in the conventional therapy treatment based on intramuscular injection of salmon calcitonin and with PEMF treatment can significantly reduce the patient's pain, increase bone density, efficacy, adverse reactions, with some clinical reference significance.

The effects of radix hedysari polysaccharide (RHPS)and Astragli polysac-charide(APS)on immune function was studied in normal mice and in themice whose immune function had been suppressed by the use ofcyclophosphamide(CY)or prednisolone(PDS).RHPS or APS 500mg,1000mg/kg ip qd?6d to mice,could increase spleen weight(p

OBJECTIVE:To evaluate the safety of endovascular stent implantation in treating carotid artery stenosis and analyze the stenosis rate and hemodynamics following stent implantation.METHODS:Self-control experiments concerning endovascular stent implantation for carotid artery stenosis were searched in CNKI published between 2000 and 2008 with the of "carotid artery stenosis,endovascular stent implantation".The data of each experiment were extracted and analyzed.RESULTS:A total of 17 experiments involving 522 cases of carotid artery stenosis were accorded with the inclusion criteria.The stenosis rate was reduced after endovascular stent implantation.Follow-up results show that the stent has good appearance with no deformation,and the blood flow is patent in the stent,with no relapse of re-stenosis.In addition,stent implantation promotes recovery of blood flow at stenosis site,improves distal blood flow rate,attenuates blood perfusion and hemodynamic impairment and reduce stroke incidence.CONCLUSION:Endovascular stent implantation has high success rate in treating carotid artery stenosis with favorable clinical outcome.However,other effective indexes and its safety need further evaluation.