Wnt signaling pathways is a hot focus in recent years,which plays important regulatory roles in cell proliferation,differentiation and migration.Wnt signaling pathways include classical Wnt signaling pathways and non classical Wnt signaling pathways.Wnt11 is a very important signal molecule in the nonclassical WNT signaling pathways and kidney development,which plays a positive regulatory effect in the development of kidney and become silent in mature kidney.Studies have shown that Wnt11 re-express in the renal fibrosis.This paper discusses the function of the Wnt11 in kidney development and the relationship between Wnt11 and renal fibrosis.

Transformation of CDC medical library to wisdom library was elaborated from the target and tactics ac-cording to the connotation and characteristics of ubiquitous knowledge .Suggestions were put forward for CDC medi-cal library to provide knowledge management for the decision-making of public emergencies against the background of ubiquitous knowledge , such as expanding its acquisition of information resources , developing its rich and charac-teristic holdings, mining its recessive knowledge, integrating its information resources, establishing library col-leagues, developing information model of massive data, and pushing personal disease control information.

On the basis of ancient Chinese medical literature, this article summarized the clinical application of Shenmai (BL 62), an acupoint of bladder meridian of foot taiyang. Clinically,Shenmai (BL 62) is usually used to treat mental disorders, insomnia, motor system diseases and eye diseases.

Regulatory T cells are a group of subgroup T cells with special immune regulating function,which participate in keeping immune homeostasis and play important roles in preventing autoimmune diseases.However,regulatory T cells also promote tumor immune evasion.The highly increase of its expression will significantly reduce the smvival rate of cancer patients.Gastric cancer with high mortality is difficult to detect in early stage.China is one of the high-prevalence gastric cancer countrys.This article mainly introduced the sources,classification and immune phenotype of regulatory T cells and its function mechanism to explore its relationship with gastric cancer in order to discover the new strategy of tumor immunotherapy.

Chronic Disease ; Elasticity Imaging Techniques ; Humans ; Liver Diseases ; diagnostic imaging

Asthma is a chronic airway inflammatory disease.Detection and evaluation of airway inflammation has important clinical significance in asthma diagnosis and severity judgement.It is also important to select drugs,dosage,and withdrawal time for patients whose symptoms have been controlled.So,it is necessary to find the technology which can response to airway inflammation to guide the asthma diagnosis and therapy.At present,many inflammatory biomarkers have been researched including exhaled nitric oxide,leukotrienes,exhaled breath condensate determination,Periosrin,YKL-40 etc.This review summarizes the biological characteristics and clinical application of inflammatory markers in asthma.

BACKGROUND:Signal transducer and activator of transcription 3 (STAT3) and Caspase-3 are the important factors in JAK2/STAT3 signaling pathway. However, there are few studies on their role in the exercise preconditioning for myocardial protection. OBJECTIVE: To analyze the effects of exercise preconditioning on the expression of STAT3 and Caspase-3 in the heart of rats and investigate the cardioprotective mechanism of action. METHODS: Eighty Sprague-Dawley rats were randomly divided into control, exhaustive, exercise preconditioning, and exercise preconditioning+AG490 groups. The exercise preconditioning rat models were established by subjecting to intermittent treadmil exercise for 3 successive days. Rats in the control group were fed routinely for 3 days. Rats in the exhaustive group underwent treadmil exercise at 30 m/min until exhaustion after 3 days of routine raise. Rats in the exercise preconditioning group underwent exercise preconditioning for 3 days, and 24 hours later, they underwent treadmil exercises at the speed of 30 m/min until exhaustion. Rats in the exercise 

Objective To observe the clinical efficacy of acupuncture at phenomaxillary ganglia in treating dry eye syndrome (DES). Methods Totally 148 DES patients were randomized into a treatment group of 72 cases and a control group of 76 cases. The treatment group was intervened by acupuncture at phenomaxillary ganglia plus Jingming (BL 1), Sibai (ST 2), and Taiyang (EX-HN 5), while the control group was by using eye drops of artificial tears. The DES symptoms score and Visual Analogue Scale (VAS) were observed before and after intervention, and the clinical efficacies were compared. Results The total effective rate was 90.3%in the treatment group versus 68.4%in the control group, and the difference was statistically significant (P<0.01). The DES and VAS scores were significantly changed after intervention in both groups (P<0.01). The changes of DES and VAS scores in the treatment group after intervention were significantly different from those in the control group (P<0.05). Conclusions Acupuncture at phenomaxillary ganglia can go deep and directly reach the affected area, and thus is an effective method in treating DES.

Objective To summarize nursing measures of one liver cancer patient with hand-foot syndrome by onral intake of Nexavar. Methods Care focused on close observation of disease condition changes,strengthening skin care,psychological support,life care,health education and dietary care. Results The patient was discharged crred after two-week treatment.Through intensive care,the patient was discharged from hospital after 2 weeks. Conclusions To teach patients self-observation and prevention measures of hand-foot syndrome can ensure early detection,early treatment and early recovery of them.

The effects of radix hedysari polysaccharide (RHPS)and Astragli polysac-charide(APS)on immune function was studied in normal mice and in themice whose immune function had been suppressed by the use ofcyclophosphamide(CY)or prednisolone(PDS).RHPS or APS 500mg,1000mg/kg ip qd?6d to mice,could increase spleen weight(p