Strengthening the protection of intellectual property of scientific academies and institutes is not only an important task facing scientific institutions but also an issue demanding the attention of hospital managers. The author explained in the first place the significance of intellectual property protection and pointed out some problems that exist currently in China in this aspect. Then he put forward some measures for strengthening intellectual property protection. These include: ①enhancing the awareness of intellectual property protection; ②attaching importance to the differentiation between property rights of service inventions and those of non service inventions; ③rendering intellectual property protection systematic; ④earmarking funds for intellectual property protection and stressing centralized management of intellectual property protection by specialized departments.

Objective To investigate the effectiveness and safety of angled percutaneous vertebroplasty (PCVP) in the treatment of osteoporotic vertebral compression fractures (OVCF) based on the meta-analysis method. Methods Randomized controlled trials (RCT) or retrospective cohort studies (RCS) regarding PCVP and percutaneous vertebroplasty (PVP) for the treatment of OVCF were retrieved from PubMed, Cochrane Library, Web of Science, CNKI, and Wanfang Data from inception to September 13, 2023. The literature was screened according to inclusion and exclusion criteria, and a meta-analysis was performed. The outcome indicators included postoperative Visual Analogue Scale (VAS) score, postoperative Oswestry Disability Index (ODI) score, postoperative Cobb angle, postoperative vertebral height, operative time, intraoperative fluoroscopy times, bone cement injection volume, excellent and good rate of bone cement vertebral body distribution, bone cement leakage rate, and re-fracture rate. Results A total of 20 articles, including 12 RCT articles and 8 RCS articles, were included in this meta-analysis. Compared with the PVP group, the PCVP group had lower postoperative VAS scores (MD=-0.15, 95%CI, -0.18 to -0.11, P < 0.000 01), lower postoperative ODI scores (MD=-1.63, 95%CI, -3.06 to -0.19, P=0.03), shorter operative time (MD= -7.15, 95%CI, -10.74 to -3.56, P < 0.000 1), less intraoperative fluoroscopy times (MD=-3.40, 95%CI, -5.71 to -1.10, P=0.004), a higher excellent and good rate of bone cement vertebral body distribution (OR=5.84, 95%CI, 3.58 to 9.51, P < 0.000 01), and a lower bone cement leakage rate (OR=0.31, 95%CI, 0.23 to 0.42, P < 0.000 01). However, there were no significant differences in postoperative Cobb angle, postoperative vertebral height, bone cement injection volume, and re-fracture rate between the PCVP group and the PVP group (P>0.05). Conclusion Compared with PVP, PCVP has better effectiveness and safety in the treatment of OVCF, which can relieve pain, shorten operative time, reduce intraoperative fluoroscopy times and bone cement leakage rate, improve the excellent and good rate of bone cement vertebral body distribution, and enhance spinal function. If conditions permit, PCVP is recommended for the treatment of OVCF.

The renin-angiotension system (RAS) plays an important role in cardiovascular and renal physiology and diseases. Recent discoveries of prorenin and prorenin receptor add new contents to RAS. Renin and prorenin binding to the prorenin receptor not only target and facilitate angiotensin generation but also lead to activation of prorenin receptor signal transduction pathways, which is distinct from classical RAS signaling. In this paper, the construction, function and signal trasduction of prorenin, prorenin receptor and handle region peptide are reviewed.

Chinese patent medicines have unique advantages in treatment of diabetes. This article provides a comprehensive review of the classification, analysis and evaluation of the post-marketed Chinese patent medicines for diabetes and proposes that pure TCM preparations and Chinese/western compound preparations should be considered differently in regards to their clinical uses. TCM symptom-complex differentiation is the common guideline for rational use of both pure TCM preparations Chinese/western compound preparations. Moreover, the Chinese/western compound preparations should be used in accordance to the indications of the western medicine contained and strictly under the physician's instruction. Education and training of rational medication usage, basic and clinical study on post-marketed medicines are important measures to control and reduce medication risk.

BACKGROUND: A large amount of studies have demonstrated that stem cells in the heart of mammal participate in heart self-renewal and endogenous repair.OBJECTIVE: To summarize the source, classification, features of cardiac stem cells and application in heart disease. METHODS: A computer-based online search of PubMed database was performed for articles published between January 2000 and December 2010 related to the source, classification, features of cardiac stem cells and its effects on myocardial regeneration with key words cardiac stem cell. Clinical studies and basic studies were all included. Repetitive studies and Meta analysis were excluded. Finally, 32 articles were included.RESULTS AND CONCLUSION: Cardiac stem cell is a type of stem cells in the heart, with properties of self-renewal and cloning proliferation. It can differentiate into cardiomyocyte and endothelial cell and plays a role in heart injury repair to improve heart function. Cardiac stem cells have been in vitro isolated, cultured and amplified to transplant into animal heart, which lays a foundation for clinical application. However, some questions remain poorly understood as to the homeostasis and dynamic changes, processes involved in their differentiation into heart functioning cells, as well as influential factors and regulation.

0.05).(2)The plasma GMP-140 levels of both groups was remarkably increased immediately and a decreased trend 24 h after PCI,but did not return to normal(P

Objective To investigate the effect of propofol on N-methyl-D-aspartate (NMDA) receptor-mediated currents. Methods Hippocampal neurons were prepared from newborn Wistar rats and cultured for 8-12 days. Whole cell currents were recorded using patch-clamp technique and cells were voltaged-clamped at - 80 mV. 100 ?mol?L-1 NMDA and 3 or 48 ?g?ml-1 propofol were applied with a multi-pipe ejection system. GABAA receptor was then blocked with 100 ?mol?L-1 bicuculline to investigate the effect of propofol on NMDA receptor without the influence of GABAA receptor.Results Run-down of INMDA induced by 100 ?mol?L-1 NMDA applied to neurons which were cultured for 8-12 days was 15%?8%. Propofol 3 or 48 ?g?ml-1 significantly inhibited spontaneous excitatory postsynaptic currents and elicited a Cl- -mediated response by direct activation of GABAA receptor in the absence of GABA. therefore produced a reversible inhibition of whole cell currents activated by NMDA. After the GABAA receptor was blocked by 100 ?mol?L-1 bicuculine propofol still inhibited NMDA currents slightly. Conclusion Propofol inhibits the NMDA subtype of glutamate receptor mainly through activation of GABAA receptor. It can also directly suppress the NMDA receptor slightly.

Objective To explore the effects of Baogan Jiedu Granule on lipid peroxidation of free radicals in acute liver injury mice induced by tripterygium glycosides.Methods Totally 60 mice were randomly divided into tripterygium glycosides model group,large-dose,medium-dose and small-dose groups of Baogan Jiedu Granule,Ganlixin group and control group.Each group was respectively perfused with the corresponding drug for 5 days and tripterygium glycosides were perfused once to make the model.The serum levels of ALT,AST,SOD,MDA and GSH-Px were measured.Results The serum levels of SOD and GSH-Px in model group decreased and MDA rose obviously.Compared with model group,Baogan Jiedu Granule of all doses could effectively decrease ALT,AST and MDA level and obviously improve GSH-Px level in each group.In addition,in the large-dose group SOD level was markedly improved(P