Objective To investigate the influence of rosuvastatin on inflammatory factors and immune func-tion in chronic obstructive pulmonary disease(COPD)with pulmonary heart disease.Methods 80 COPD patients with pulmonary heart disease were randomly divided into two groups,40 cases in each group.The control group was treated with conventional medicine comprehensive treatment,the observation group was given rosuvastatin based on the control group.The inflammatory cytokines (TNF -α,IL -1 and hs -CRP)changes,immunoglobulin IgM,IgG and IgA changes situation,and heart,lung function changes related indicators were compared between the two groups before and after the treatment.Results After treatment,the TNF -α,IL -1 and hs CRP levels of the observation group were significantly lower than those before treatment(t =145.5,35.35,57.5,all P <0.05)and those of the control group(t =160.75,11.45,32.99,all P <0.05).After treatment,the IgM,IgG and IgA levels of the observa-tion group were significantly lower than those before treatment (t =4.89 of 18.29,3.42,all P <0.05)and those of the control group (t =2.55 9.67,2.342,all P <0.05 ).After treatment,the FEV1 ,FEV1 /FVC and LVEF of the observation group were significantly higher than those before treatment(t =40.44 33.64,33.79,all P <0.05),while the PAP level was significantly lower than that before treatment (t =24.12,P <0.05),and the FEV1 ,FEV1 /FVC and LVEF of the observation group were significantly higher than those of the control group after treatment(t =16.30, 15.82,18.72,all P <0.05),while the PAP level was significantly lower than that of the control group after treatment (t =13.43,P <0.05).Conclusion Combined rosuvastatin therapy for COPD patients with pulmonary heart disease can effectively reduce body inflammatory response,improve immune function and myocardial contractility,so it can promote functional recovery of heart and lung in patients.

OBJECTIVE:To improve the efficiency and accuracy in database management of drug storehouse.METH?ODS:The computerized database management pattern of drug storehouse in the hospital where the authors work was intro?duced as follows:the account books of storehouse in-and out-record as well as invoice payments were established in Excel by computers,and these drug storehouse data were managed with the support of‘Military Health No.1’system.RESULTS&CONCLUSION:The established pattern can fill in the gap in‘Military Health No.1’system and improve the database man?agement of drug storehouse in hospital.

Objective: To study the significance of DNA content in oral squamous cell carcinoma (SCC).Methods: DNA content and cell cycle of the cells in 18 cases of oral SCC were analized by image cytometry (ICM). Results: The DNA index (DI) and proliferation index (PI) were remarkably heigher in SCC than in normal epithelium ( P

Objective To study effects of exectin hydrochloride and intensity modulated radiotherapy in treatment of patients with advanced lung cancer and its effect on levels of carcinoembryonic antigen (CEA), neuron-specific enolase (NSE) and serum glycoprotein antigen 199 (CA199). Methods 88 patients with advanced lung cancer were selected from June 2014 to June 2016 in our hospital were selected and randomly divided into observation group and control group, 44 cases in each group.In the control group, the patients were treated with IMRT, and the observation group was treated with exectin hydrochloride on the basis of control group.The clinical efficacy and adverse reaction were compared between the two groups.The levels of CEA, NSE and CA199 before and after treatment were analyzed.Results After treatment, the total effective rate in the observation group 84.09% was significantly higher than the control group 52.27%, the difference was statistically significant (P<0.05).Before treatment, the levels of CEA, NSE and CA199 of the two groups had no significantly different, after treatment, the levels of CEA, NSE and CA199 of the two groups were significantly lower than before treatment, the difference was statistically significant (P<0.05).CEA, NSE, CA199 levels in the observation group were significantly lower than the control group, the difference was statistically significant (P<0.05).There was no significant difference in adverse reaction rate of I-II, III-IV liver function, gastrointestinal reaction, bone marrow suppression and acute radiation pneumonitis in observation group and control group.Conclusion Ectectin hydrochloride combined with intensity modulated radiotherapy can effectively reduce the levels of CEA, NSE and CA199 in patients with advanced lung cancer, and the clinical efficacy is good, and will not increase the adverse reaction rate.

Acute superior mesenteric artery embolism(MAE) is uncommon in clinical, but is a severe surgical abdomen. Owing to its unfamiliarity, clinicians often made misdiagnosis. This report summarized the experience in diagnosis and surgical therapy of 25 cases of acute superior mesenteric artery embolism. The results suggested that patients with a history of heart and peripheral arterial obstructive disease encountering severe abdominal pain and hemorrhage of digestive tract, which could not be relieved by narcotics, should be considered as early signs of acute superior mesenteric artery embolism. Twenty-three were operated out of the 25 cases, among tham, 5 cases were subjected to resection of partial small intestine after removal of the embolus, 18 cases received bowel resection. In the 23 cases of MAE, 10 were cured and 13 died, the mortality in perioperative period was 57%. Early diagnosis and prompt treatment are the key to improve the therapeutic effects of AME.

The identification of the relationships between mutations of the bone morphogenetic protein type Ⅱ receptor (BMPR2) and pulmonary arterial hypertension (PAH) has been considered to be one of the most significant discoveries in this area in the 21st century. And BMPR2 mutation is responsible for the majority of hereditary PAH as well as some of idiopathic PAH. Furthermore, clinical and animal expreimental research over the past few years has revealed that BMPR2 signaling pathway plays a critical role in the initiation and progress of PAH, by participateing in the pathogenesis of PAH. In addition, the potential that BMPR2 signaling pathway is used as a therapeutic target is being evaluated. This review summarizes our current understanding of the role of BMPR2 mutations in PAH from the perspectives of genetics, epigenetics, inflammation as well as interactions with other significant pathways.

Objective To evaluate the effect of SYNTAX score in the emergency revascularization strategy selection in ST‐segment elevation myocardial infarction patients with multi‐vessel disease(MVD) and to analyze the patient′s prognosis and influen‐cing factors .Methods A total of 144 patients with STEMI complicating MVD verified by coronary arterial angiography in the Xin‐qiao Hospital of Third Military Medical University from August 2010 to March 2012 were collected and divided into the once com‐plete revascularization group (CR group) ,staged complete revascularization group (SR group) and incomplete revascularization group (IR group) according to different emergency PCI strategies .The basic clinical conditions and coronary arterial SYNTAX score were recorded .The occurrence rate of major adverse cardiovascular events (MACCE) during 12 months follow up period was performed the statistics .The results of coronary arterial angiography were collected .The effect of different strategy on prognosis and the risk factors affecting prognosis were analyzed .Results There was no statistically significant difference in the all‐cause mor‐tality between the IR group with the CR and SR groups (P>0 .05) ,while the cerebrovascular event ,repeat revascularization during hospitalization ,AMI and total MACCE occurrence rate had statistical difference between the IR group with the CR and SR groups (P<0 .05) .The main influence factors of MACCE were complicating diabetes mellitus ,type C lesions ,SYNTAX score ,D‐B time , myocardial infarction area ,TIMI score in PCI ,no reflow existence and cardiac shock (P<0 .05) .According to the SYNTAX score , the occurrence rate of MACCE in mild or severe lesions had no statistical difference among 3 groups(P> 0 .05) ,while which in moderate lesion had statistical difference among 3 groups(P<0 .05) ,the CR group had the highest occurrence rate of MACCE . Conclusion For the patients with STEMI complicating MVD ,the SYNTAX score can be used as the evidence for selecting reperfu‐sion strategies and applied in emergency PCI .

Objective To study the outward potassium current in myocytes from septic shock rats and the effects of adrenomedullin(ADM).Methods Ventricular myocytes were isolated from adult rats 4 h after an intraperitoneal injection of lipopolysaccharide(LPS,10 mg/kg).Transient outward K~+ current(I_(to)),steady-state K+ current(I_(ss))and ATP sensitive potassium current(I_(K,ATP))were recorded using whole cell patch-clamp methods.Results LPS treatment had no effect on Ito and Iss.The I_(K,ATP) density in septic shock group[(2.66±0.56) pA/pF,n=12]was significantly higher than that in control group[(0.27±0.08) pA/pF,n=14,P＜0.01].The ADM antagonist ADM-(22-52)significantly reversed the increased I_(K,ATP)[(0.69±0.21) pA/pF,n=11,P＜0.01 vs LPS group]in shock myocytes.I_(K,ATP) density was lower in LPS plus aminoguanidine myocytes[(0.77±0.18) pA/pF,n=10,P＜0.01 vs LPS group]than that in LPS myocytes.ADM-(22-52)and 100 μmol/L aminoguanidine could completely abolish the increase in I_(K,ATP).Conclusion I_(K,ATP) was activated in myocytes from septic shock rats.Adrenomedullin along with NO precipitated activation of the I_(K,ATP) in rat ventricular myocytes during septic shock.

Objective To investigate indications,technique,prognosis and complications of anterior flap hemipelvectomy (hemipelvectomy using a quadriceps femoris muscle flap with superficial femoral artery)in the treatment of pelvic tumors.Methods From April 2009 to October 2010,10 patients with pelvic tumors underwent anterior flap hemipelvectomy in our department.There were 9 males and 1 female,aged from 30 to 62 years (average,46 years).There were 7 cases of chondrosarcoma,1 case of epithelioid sarcoma,1 case of pleomorphic liposarcoma and 1 case of spindle cell sarcoma.Results Nine patients were followed up for 12 to 30 months (average,21.5 months).Superficial skin necrosis occurred in 1 patient,while there was no wound infection.Local recurrence (33.3％) occurred in 3 patients,including 2 cases of chondrosarcoma and 1 case of epithelioid sarcoma.Three patients died at last,including 2 patients with local recurrence and 1 with pulmonary metastasis from liposarcoma.Two patients survived with pulmonary metastasis,and remaining 3 patients survived without recurrence and metastasis.Conclusion Anterior flap hemipelvectomy is indicated for:(1) patients with extensive soft tissue sarcoma in the buttock,and the tumor or reaction zone involve the subcutaneous tissue; (2) patients with recurrent pelvic tumors,and the conventional posterior flap can't be used due to contamination by the original incision; (3) patients whose posterior flap has poor blood supply due to radiotherapy or other factors.The prerequisite of the surgery is that the blood stream between external iliac artery and femoral artery is unobstructed; moreover the blood vessels are not in the tumor reaction zone.Compared with conventional posterior flap,the anterior flap hemipelvectomy is an easier procedure,which not only can easily cover surgical defect and obtain better surgical margin,but also has less complications.

Objective To investigate the expressions of vascular endothelial growth factor (VEGF)-C,-D and VEGF receptor-3 (VEGFR-3/Flt-4) in pN0 early gastric cancer (ECG) and their relationship with lymph node micrometastasis.Methods From January 2005 to January 2010,the paraffin-embedded specimens of 61 pN0 ECG were collected.The expressions of VEGF-C,VEGF-D and VEGFR-3 in 61 pN0 early gastric cancer tissue,25 adjacent tissue and CAM5.2 expression in 868 hematoxylin-eosin staining negative lymph nodes were detected by immunohistochemical assay.The rate of lymph node micrometastasis of 61 pN0 ECG was evaluated.According to the data type,t test,x2 test or Fisher exact probability were performed for the relationship analysis between the expressions of VEGF-C,VEGF-D and VEGFR-3 in pN0 stage ECG and lymph node micrometastasis.Results The high expressions of VEGF-C,VEGF-D and VEGFR-3 in the 61 pN0 ECG were 34.4％ (21/61),34.4％ (21/61) and 44.3％ (27/61) respectively,which were higher than those of adjacent tissues [12.0％ (3/25),8.0％ (2/25) and 16.0％ (4/25) respectively] (x2=4.433,6.321 and 6.144 respectively,all P＜0.05).There were 10 cases (16.4％) of pN0 ECG with lymph node micrometastasis.In pN0 ECG,the low expressions of VEGF-C and VEGFR-3 in negative Flt-4 vascular invasion (FVI) were common than positive FVI (x2 =15.828,6.879 and 9.244,all P＜0.05).The high expressions of VEGF-C and VEGFR-3 were related to the depth of tumor invasion (x2 =5.561 and 5.678,both P＜0.05),the density of VEGFR 3 positive vascular (FVD) (t=2.987and 5.652,both P＜0.01) and lymph node micrometastasis (x2 =6.705 and 6.192,both P＜0.05),but not related to the degree of differentiation (P＞0.05).However,the high expression of VEGF-D was not related to depth of tumor invasion,FVD and lymph node micrometastasis (all P＞0.05),but related to the degree of differentiation (x2 =8.472,P =0.004).The high expressions of VEGF-C,VEGF-D and VEGFR-3 were not related to gender,age,tumor location,macroscopic type and tumor size (all P＞0.05).Conclusions The high expressions of VEGF-C,VEGFR-3 were related to lymph node micrometastasis in pN0 ECG.Although the high expression of VEGF-D was not related to lymph node micrometastasis,it could indirectly affect lymph node micrometastasis through VEGF-C-VEGFR-3 axis in pN0 ECG.