1.Practical value of low-dose CT scanning in simulated location of lung cancer
Zhigang LI ; Hongyun SHI ; Xiaohui GAI ; Miaoling LIU
Chinese Journal of Radiation Oncology 2013;(3):237-238
Objective This paper studies on feasibility of low dose CT scanning in lung cancer patients simulated localisation.Methods 62 patients cases of lung cancer are selected.Scan parameter:scan twice by 20/100 mA,the other parameter remain unchanged as voltage of 120 kV,thickness of 5 mm,pitch of 1:1 and scan time of 1 s.After scan,picture quality was evaluated according to excellent,good,bad under different condition.Volume of target was determined by treatment planning system.Data such as dose index value of single helical scan,z-axis scan range,dose length product value and etc.are recorded in order to evaluate radiation dose of patients.Picture quality and the difference of radiation dose were statistically analyzed using Fisher's and pair t-test.Results Picture quality of low dose scanning was a little bit lower than that of normal dose,however,picture quality difference of difference dose scanning was statistically meaningless (number of patients according to excellent,good,bad were 46,13,3 and 50,11,1,P =0.541).There is no obvious difference of target volume under different dose scanning in the same (36.78 cm3,40.35 cm3,t =2.57,P =0.189).Radiation dose of low dose scanning group is far less than that of high dose scanning group and the difference is obvious (133.05 mGy,941.25 mGy,t =-41.24,P =0.000).Conclusions Low dose scanning of 20 mA current during CT simulated localisation tremendously reduces harm that may happen to patients during CT scan,while tumor target delineation and scanned picture quality is guaranteed.
2. Preliminary study of the relationship between the expression of NRAGE and the therapeutic effect of radiotherapy in patients with esophageal squamous cell carcinoma
Zhesen TIAN ; Huizhi LIU ; Huandi ZHOU ; Yufeng ZHANG ; Ge ZHANG ; Xiaohui GAI ; Chunmei LIU ; Xiaoying XUE
Chinese Journal of Radiation Oncology 2019;28(10):746-748
Objective:
To detect the expression of NRAGE protein in esophageal squamous cell carcinoma and investigate the relationship between NRAGE and therapeutic effect of radiotherapy.
Methods:
The expression level of NRAGE in 44 patients with esophageal squamous cell carcinoma was evaluated by immunohistochemistry and statistically analyzed along with clinical data by using multivariate analysis using Cox regression model.
Results:
The overall expression level of NRAGE protein in esophageal squamous cell carcinoma (