Objective To analyze the prescriptions containing Panlongqi Pieces for clinical application;To guide reasonable usage of medicine in clinic. Methods Adopted retrospective investigation method by selecting 1178 prescriptions of Chinese patent medicine containing Panlongqi Pieces from January to March in 2014. The unreasonable elements in these prescriptions were analyzed. Results Among the 1178 prescriptions, there were 585 unreasonable prescriptions, occupying 49.66%. Problems in the application of Panlongqi Pieces in clinic lie in differentiation of syndromes, combination of medication, incompatibility of medicine in prescription, and usage and dosage. Conclusion Doctors should attach importance to differentiation and reasonable usage in clinical application, which can achieve expected therapeutic effect.

Objective To establish relevant management measures and guarantee the safety of clinical medication by analyzing the quality of warehouse entry inspection for Chinese decoction pieces.Methods According to the records of warehouse entry inspection for Chinese decoction pieces during January 2014 to December 2014, reasons for unqualified Chinese decoction pieces were collected and analyzed.Results Our hospital checked and accepted 2376 batches of Chinese decoction pieces, among which 98 batched were unqualified (4.12%); the reasons for unqualified Chinese decoction pieces mainly included improper storage, adulteration, and nonstandard preparation, which accounted for 48.97%, 19.39% and 18.37% respectively.Conclusion There are some problems in the Chinese decoction pieces in our hospital. Dispensary of TCM should enhance the management of check and acceptance of Chinese decoction pieces, and improve quality for check and acceptance and quality of Chinese decoction pieces.

The role of neutrophil in the pathogenesis of many diseases attracts more attentions than before. Neutrophil elastase (NE), a powerful neutrol proteinase capable of causing major tissue destruction in many diseases, is mainly present in the azurophil granules of neutrophil. A solid-phase enzyme-linked immunosorbent-biotin assay for human NE has been developed. Only 20?l of plasma sample is needed. Non-smoking healthy adults have 33.7?6.7ng NE/ml plasma; patients with chronic obstructive pulmonary diseases, 48.0+ 10.9 ng NE/ml; patients with pyogenic dermatisis, 69.1?15.7 ng NE/ml; patients with systemic lupus erythematosus, 61.0?13.9 ng NE/ml; patients with aplastic anemia, only 12.3?5.3 ng NE/ml. All of these results have significant differences compared with the result of healthy adults. The results of assay showed that this quantitative assay with good specificity and accuracy may be a better criterion for investigating the effect of NE on pathogenesis of some diseases.

Objective: To explore the effect of sequential external counterpulsation on sudden deafness.Methods: All the patients were treated with sequential external counterpulsation instrument produced by Guangzhou South-China Medical Instrument Company.Results: After treatment,the hearing threshold of 60 cases was all improved,with an increase from 5 to 53 db,and with an average threshold shift of 29?8.7db.86.7% of cases acquired satisfied therapeutic effects except 8 cases whose hearing threshold increased by less than 15db.Conclusion: the results showed that,the treatment of sudden deafness with Sequential External Counterpulsation has good therapeutic effects.Earlier and longer treatment means better effect

Objective To analyze the usage of TCM decoction pieces in our hospital during 2011-2014;To provide references for clinical reasonable medicine using. Methods Statistic analysis was carried out from the aspects of annual amount of prescription, dosage, annual sales, and top 10 TCM decoction pieces among sales rank through management system of hospital pharmacy. Results Sales amount and dosage of TCM decoction pieces increased significantly. During the four years, six same TCM decoction pieces ranked among the dosage of top 10 TCM decoction pieces, namely Astragali Radix, Paeoniae Radix Alba, Angelicae Sinensis Radix, Salviae Miltiorrhizae Radix et Rhizoma, fried Atractylodis Macrocephalae Rhizoma, and Chuanxiong Rhizoma. The amount of prescription increased obviously. Conclusion TCM decoction pieces are commonly used in our hospital;dosage increased continuously;usage is generally reasonable.

Lactoferrin has antitumoral activity. Lactoferrin exerts anti-carcinogenic effects via its ability to modulate host immunity, suppress proliferation, induce apoptosis, block cell cycle, inhibit angiogenesis, regulate carcinogen-metabolizing enzymes and sequester iron, etc. Safety and no toxicity of lactoferrin provide a new selection for cancer treatment.

AIM: To study the efficacy and adverse reactions of venlafaxine in the treatment of generalized anxiety disorder.　METHODS: Twenty-one patients (M 13, F 8; age 33 a± s 16 a) with diagnosis of generalized anxiety disorder according to CCMD-Ⅱ-R were treated with venlafaxine 50 mg*d-1 for 4 wk. Patients were assessed with the HAMA and TESS and routine experimental examination before and after treatment.　RESULTS: Venlafaxine was obvious effective to generalized anxiety disorder. The effectiveness appeared after 1 wk. The remarkable effective rate was 76% at 4 wk. The main adverse reactions of venlafaxine were thirst, sweating nausea and headache etc. 　CONCLUSION: Venlafaxine is an effective and safe drug in the treatment of generalized anxiety disorder.

Based on the issue of medical English teaching, according to the immersion theory,we improved teachers' oral English, gave students a good foreign language circumstance, set students as the teaching center.to let them join the teaching activity and graspe medical English. All teaching reform worked well.

Objective To survey the unconventional blood sugar level induced by quinolones and promote the rational drug use in clinical. Methods Collecting and analysis the unconventional blood sugar level induced by quinolones reported during the period of 1995 ～ 2008 using CHKD net. Results 107 cases of unconventional blood sugar level were reported by using 9 kinds of quinolones and among them 70 cases with hypoglycemia and 3 cases died of hypoglycemic coma. Another 37 cases were found with hyperglycemia. Conclusion Should reinforce the supervi-sion of rational use of quinolones and monitor the blood sugar level when the elderly and the diabetic of renal insuffi-ciency in clinical use.

A 69-year-old male patient presented with a gradually enlarging mass in the left inner upper thigh for more than 2 months,and pigmented patches in the left medial leg for more than 20 years.Physical examination revealed a painless mass measuring 3 cm × 2 cm × 2 cm in size in the left inner upper thigh.Several pigmented patches were observed in the left medial leg,and the largest pigmented patch measured 2 cm× 2 cm in size with an irregular border and uneven pigmentation.The mass in the left inner upper thigh was resected and subjected to histopathological examination,which showed proliferative epithelioid neoplastic cells with mucous matrix,round and spindle cells of varying sizes separated by mucous matrix.The immunohistochemical study of tumor cells showed positive staining for vimentin,S100 and Melan-A,but negative staining for actin,desmin,CD56,epithelial membrane antigen,cytokeratin,leukocyte common antigen,CD99,chromogranin A and synaptophysin.Hematoxylin-eosin staining of pigmented patches on the left medial leg revealed squamous epithelium covering the surface of lesions with no superficial ulceration or atypia in epithelial cells,unevenly distributed melanophages,fibroplasia accompanied by collagen formation,obviously decreased skin appendages,infiltration of a few inflammatory cells in the dermis.AB-PAS staining was negative.The immunohistochemical study of pigmented patches showed positive staining for vimentin and Melan-A.The patient was pathologically diagnosed with metastatic myxoid melanoma with partial regression of the primary lesion.