Genetic researches have been paid more attention in dentistry area recent years;however,researches mainly focus on the tooth specific genetic diseases.In this review,we review the detailed genetic syndromes which are related with abnormal enamel and dentin.We wish this review will be helpful to those who are interested in oral genetic research.

CYP2C9 is an important enzyme of drug metabolism expressed in liver, It can metabolize several clinically important drugs, some with a low therapeutic index. This review summarizes the CYP2C9 gene structure, induction mechanism, known polymorphism and functional significances and their population frequencies.

Our army medical morals was engendered and developed along with our army medical treatment work.This text is tight and tight hold the "a thought","twice important history affairs","two standard points"and "a slogan",tally up developments experience of the Land Revolution,expatiated process and the basically composition of the mode.

Dental Research ; Humans ; Mouth Diseases ; genetics ; Research Design

Computational Biology ; Genetic Diseases, Inborn ; Humans ; Mouth Diseases ; genetics

Genetic Research ; Humans ; Mouth Diseases ; genetics ; Rare Diseases ; genetics

Craniofacial Abnormalities ; Humans

Dental Enamel ; Hardness ; Humans ; Tooth Diseases ; genetics

Genetic Diseases, Inborn ; diagnosis ; Humans ; Mouth Diseases ; diagnosis ; genetics

砄bjective: To establish an immortalized chondrocyte cell line derived from rabbit mandibular condyle without loss of chondrocyte phenotype. Methods: SV 40 large T antigen gene was conducted into primarily cultured mandibualr condylar chondrocytes (MCCs) of 1-2 week old New Zealand rabbits using an recombinant retroviral vector's transfecting method. After cultured in selective medium containing 400 ?g/ml G418 for 3 weeks, colonies were isolated and expanded for further study. Slot blot analysis was used to detect the transcript of type I and type II collagen of the transgenic cells. Results: One of the positive clones had been maintained for 100 passages for nearly one and half year, without any sign of senescence, and termed immortalized mandibular condylar chondrocyte (IMCC). Transcripts of pro ?1 ( I ) and ?1 ( II ) collagen was observed in IMCCs and MCCs by RNA blot. Conclusion: IMCC is an immortalized chondrocyte cell line derived from rabbit mandibular condyle and might be a good model for studying the biological character of MCC.