Objective To investigate the prevMenee depression in pregnant women during the first trimester in Chengdu.Methods Women in pregnancy for less than 12% weeks were enrolled in this study.They were investigated about depression condition by fulling out the EPDS and the self-compiled related factor forms.Results The pmvulence of depression was 39.1% at the pregnancy during the first trimester.The prevalence of depressive symptoms was significantly higher in women with induced abortion more than 2 times than those less than 2 times,also higher in women with unexpected pregnancy than those planned pregnancy. Conclusions The depression emotional disorder in the pregnancy women during the fast trimester is high.The doctorand nurse should pay close attention to those women to reduce depression.