Salivary gland adenoid cystic carcinoma is one of the most common malignant salivary gland tumors.Its invasion and metastasis are multi-stage and multifactorial processes,in which complex mechanisms and multiple signaling pathways are involved.Here,this article reviews the research progress in signaling pathways of salivary gland adenoid cystic carcinoma.

Objective:To observe the curative effect and security of nicardipine combined with metoprolol succinate sustained-release tablet on renal hypertension.Method:65 renal hypertension patients were randomly divided into two groups.The patients in the nicardipine group were treated with nicardipine 80 mg q8h,while the patients in the therapy group were treated with nicardipine 40mg qd and metoprolol succinate sustained-release tablet 47.5-95mg qd for 8 weeks.Their blood pressure,heart rate,hepatic function,renal function,blood glucose and lipid were observed and recorded before and after the treatment.Result:The total efficiency was 74.4%in the controlled group and 88.5%in the therapy group,respectively. There were no obvious changes or obvious adverse reactions in their heart rate,hepatic function,renal function,blood glucose and lipid after the treatment.Conclusion:Nicardipine combined with metoprolol succinate sustained-release tablet is efficient and safe but more efficient than nicardipine alone in the treatment of renal hypertension.

The paper analyzes current situation of the non -medical majors and literature information retrieval course in Traditional Chinese Medicine ( TCM) colleges and universities , points out the course reform objectives and key points .By taking Liaoning Universi-ty of Traditional Chinese Medicine as an example , it discusses the characteristics of non -medical majors and needs for the literature in-formation retrieval course , and proposes the teaching approach of literature information retrieval course for non -medical majors in TCM colleges and universities .

Objective To observe the effect of formaldehyde exposure on the progress of explanted S180 tumour and the serum p53 antibody in mice. Methods 30 male SPF Kunming mice aged 6 weeks were randomly divided into control group,tumour group and formaldehyde group which drunk purified water,purified water contained 0.05% formaldehyde respectively. One week later S180 tumour cells (2?106) were implanted subcutaneously in the left fore armpit in tumour and formaldehyde group mice. The general state (weight,activity and spirit state),the appearing time and progress of solid tumour was recorded. Four weeks later the animal were sacrificed,the weight and volume of the tumour were measured,the serum p53 antibody was examined by ELISA. Results The activity and spirit state was normal in control group. In tumour and formaldehyde group the mice had withered hair and cachexia,such as emaciated,tired,retardation. In formaldehyde group the weight increase was slow in the first and second week,however it was rapid in 3 and 4 week,the appearing time of solid tumour was advanced,the weight,volume of the tumour were higher than those in tumour group(P

Objective:To observe the effects of sodium butyrate on the expression of CD86 molecule on acute leukemia cells and explore the mechanisms of action.Methods:The expression of CD86 in NB4,HL-60 and U937 treated by SB or not was assayed by flow cytometric analysis.The alteration of CD86 mRNA was examined by semiquantitative RT-PCR.AUT gel electrophoresis was applied to check the state of histone acetylation.The content of phospho-CREB was assayed by pCREB kit.Results:Up-regulation of CD86 was observed on those cells treated by SB.The levels of CD86 mRNA in SB treated cells were statistically enhanced.The acetylation degrees of SB treated cells were higher than control groups.The contents of phospho-CREB were also raised in SB treated cells.Conclusion:SB can improve the acetylation states of acute leukemia cells,remodel the chromatin which contributes to the binding on DNA of transcription factors,such as CREB and then promote the transcription and expression of CD86.

[Objective] To explore the surgery protocol of the serious dislocation of acromio-clavieular joint,and compare the outcome of ORIF with AO/ASIF clavicle hook plate only to ORIF with eoraco-clavieular ligament reconstruction.[Method]Fity-two cases of the dislocation of acromio-clavicular joint were reviewed,Group A was ORIF only including 29 cases(male 20,female 9,mean age 45),according to the system of Rockwood,as TypeⅢ in 12 patients,TypeⅣ in 15 patients and TypeⅤ in 2 patients,the other 23 cases ORIF with eoraeo-clavieular l ligament reconstruction was Group B(male 15,female 8,mean age 50.6),according to the system of Rockwood,as TypeⅢ in 9 patients,TypeⅣ in 13 patients and TypeⅤ in 1 patients,AO/ASIF claviadar hook plates were used for all of the ORIF,and modified Weaver's method was used to reconstruct eoraco-clavieular ligament.Outcome was evaluated by Lazzcano scale after 8~12 months,and data was analyzed by SPSS 10.0.[Result]Good outcome was achieved in all of the patients,there was no significanty statistical difference between the two groups.[Conclusion]Clavicle hook plate is a kind of perfect internal fixation.Reconstruction of eoraco-clavleular ligament is not necessary if the AO/ASIF plate is used,unless serious avulsion of deltoid and trapezius muscle involved.

Objective To investigate the diagnosis and treatment of sacral nerve dysfunction syndrome.Methods Accepted 44 cases of sacral nerve disorder syndrome from Oct.2010 to Oct.2012 in the Department General Surgery of Xiangyang Central Hospital,the diagnosis and treatment of sacral nerve dysfunction syndrome were retrospectively analyzed.Results All 44 patients in this group were founded been with lumbar protrusion of the intervertebral disc,the incidence of waist 4-5 or/and sacral 1 intervertebral disc herniation was 100％.Twentyone patients were complicated with vertebral degenerative changes,6 cases with spinal arachnoid cyst.metastatic cancer without treatment in 1 case was exception,13 cases were boarded during sleeping,12 cases were given dehydration treatment with mannitol,15 cases were given therapy of sacral canal nerve block,3 cases were treated by operation.All of these treatment were proved effective.Conclusion Some certain curative effect was obtained through the local physical therapy,systemic dehydration treatment,local nerve block treatment and opertion treatment.

Objective To investigate the distribution of the bacteria in ascites of spontaneous bacterial peritonitis (SBP), and to find out the resistance of the bacteria to antibacterial agents. Methods 44 inpatients from 1999 to 2003 with SBP and positive bacterial culture in ascites were selected, and the bacterial distribution, resistance to drugs and the application of antibacterial agents were analyzed. Results 88.6% (39/44) of the 44 isolations were gram-negative bacillus, among them 28 isolations were E. coli. The results of drug sensitive test revealed that 90% of E. coli, Aeromonas sobria, Klebsiella pneumoniae were sensitive to the third generation of cephalosporin. The resistant rate of E. coli to cefotriaxone and cefotaxime were 11.54% and 12.50%, respectively. Conclusion The third generation of cephalosporin was the experiential selection in treating SBP before getting the report of drug sensitive test. Anti-bacterial agents combined with ?-lactamase inhibitors may be used in treating some severe cases.

Uveitis is an important autoimmune disease.Human leukocyte antigen (HLA)-B27-associated anterior uveitis is the most common form of anterior uveitis.HLA-B27-associated anterior uveitis has distinct ocular,systemic,and genetic features.It attacks young subjects and leads to the damage of visual function due to the recurrence and complications.However,the pathologic mechanism of HLA-B27-associated anterior uveitis is still not thoroughly understood,and effective therapy is still unavailable.There are currently many experimental researches which attamp to study the etiology and develop an effective therapy for HLA-B27 acute anterior uveitis.Thus,various animal models of acute anterior uveitis such as endotoxin-induced uveitis and HLA-B27 transgenic animals including rat and mouse are established.Different therapy regimens have been designed both in clinical trial and experimental study and aquired promising achievements.Epidemiology,pathologic mechanism,different animal models and potential new therapies such as anti-TNFα,oral associated peptides tolerance and gene therapy are overviewed.

The paper introduces the research significance of Traditional Chinese Medicine ( TCM) literature information retrieval based on cognition analysis, by analyzing cognition of literature information demands of TCM students in different majors of Liaoning University of Traditional Chinese Medicine, it studies from three perspectives:literature information retrieval demand, retrieval thinking and development direction of TCM literature information retrieval system.It also points out that study on thinking and practice of literature information retriev-al based on cognition analysis is the effective approach to enhance information literacy and improve the comprehensive quality.