Objective To study the clinical curative effect of Azithromycin in the treatment of mycoplasma pneumonia.Methods 24 cases of mycoplasma pneumonia hospitalization patients were selected and made full analysis of their medical records.Results 24 acute patients successfully cured through Azithromycin with good clinical curative effect,beginning with symptoms of fevering,coughing,wheezing,and small blisters in lungs,accompanied by external pulmonary manifestations such as diarrhea,myocardial injury and positive results of serum Mb-IgM test.Conclusion Azithromycin in treatment of mycoplasma pneumonia could quickly retum temperature,and reduc hospitalized time.

Objective To investigate feasibility, efficacy and safety of holmium laser lithotripsy under ureteroscopy to treat ureteral calculi. Methods Clinical data of 162 patients with ureteral calculi treated by holmium laser lithotripsy under ureteroscopy in our hospital from June 2006 to October 2009 were reviewed retrospectively. Stone-broken rate,lithagogue rate and complication were observed. Results The overall rate of successful fragmentation for all levels of ureteral calculi in a single procedure achieved 96. 30% (156/162). The success rates of fragmentation for the upper and mid-lower segment of ureteral calculi was 86.11% (31/36)and 99.21% (125/126),respectively. In 156 patients, the postoperative follow-up of 2- 4 weeks revealed that the stone free rate was 98.08 % (153/156). The mean operative time was (36 ± 11 )mains ( ranged from 15 to 90) and hospital stay ranged from 1 to 10 days. Conclusion Holmium laser lithotripsy under ureteroscopy is feasible,high effective and safe for the treatment of ureteral calculi, especially for those with middle or lower levels ureteral calculi.

Treated 52 cases of child diarrhea with ginger-partitioned moxibustion plus Tuina, after three treatments, all the patients are cured.

Objective To summarize the data of newborn screening in Yongchuan district of Chongqing to promote its quali‐ty ,and to provide some measurements to enhance the management of newborn screening in this area .Methods According to the management system and technical standards of newborn screening (2010 Edition) ,newborn screening in Yongchuan district was im‐plemented .Screening rate ,coverage rate of newborn screening in maternity hospital ,recall rate of suspiciously affected newborns and rate of treatment of patients were analyzed from 2013-2014 .Results The screening rate ,coverage rate of newborn screening in maternity hospital ,recall rate of suspiciously affected newborns were increased by 77 .32% ,88 .57% and 17 .44% ,respectively , during these 10 years .All patients were treated appropriately (100% ) .Congenital hypothyroidism and phenylketonuria were screened .Since 2010 ,glucose‐6‐phosphate dehydrogenase deficiency and congenital adrenal hyperplasia were added to the newborn screening test panel .Conclusion Strengthen the management ,establish administrative department ,faculty training ,health education and government financial supports are contributed to improving the quality of newborn screening .

Objective: To explore the brain damage effects of lysophasphatidyl choline(LPC) in rats with pancreatitis and explore the pathogenesis of pancreatic encephalopathy(PE).Methods: SD rats were divided into test group,control group one and control group two at random.Acute edematous pancreatits rat model was induced following Aho HJ method for test group and control group one,then test group rats were venously applied with LPC and control group one was injected saline through tail vein.Control group two was treated with venous injection LPC through the rat tails without operation.Horseradish peroxidase(HRP) was used as a tracer to detemine if the blood-brain barrier(BBB)was open 7～10 days after successive application of LPC.The extravasated tracer was showed by diaminobenzidine(DAB).Rat brain tissue sections were examined by ponceau stain and Luxol Fast Blue stain to determine whether the rat brains were demyelination at the same time.Results: The BBB permeability of the test groupLTU rats increased greatly and obvious demyelination was observed in test group rat brains while both control groups had basically intact BBB and scarce demyelination was observed in both control groups.A statistical difference existed between the test group and control groups.Conclusion:LPC definitely open the BBB of the rat pancreatitis and demyelinates the brain of pancreatitis rats thus LPC plays an important role in the pathogenesis of PE.

After the basic contents of MOOC and flipped classroom were introduced, MOOC-based flipped classroom teaching model for Chinese medical literature information retrieval course was described, its design and implementation were elaborated with CBM Database as an example.

Objective Analysis the treatment and management of thirty-six out-patients of asthma,in order to share the new experience in the implementation of the strategy.Methods Janaury 2007 36 newly diagnosed or diagnosed bronchial asthma patients in Department of Respiratory Medicine,the first affiliated hospital of China Medical University inhaled budesonide/formoterol dry powder inhalation treatment.Clinical symptoms,rescue medication,lung function and assessment questionnaire score of Asthma Control Test(ACT),Asthma Control Questionnaire(ACQ)were investigated during six months.Results After 6 months' thearopy,the majority of patients showed significant improvement.symptoms and signs got Marked improvement,indicators related to lung function increased in different degrees than before,ACQ score showed a downward trend,with the ease and alleviate symptoms of drug use reduction agreement,ACT score and an upward trend that the condition persistly revived.Conclusion When doctors institut eindividual treatment programme to patients with asthma,they should help patients learn to self-management,so as to make for the condition continued revived and long-term controlled.

Objective To investigate the effects of methylmercury on outward potassium currents in isolated outer hair cells of guinea pig cochlea.Methods The whole-cell patch clamp technique was used.Calcium sensitive outword potassium currents were recorded when the concentrations of mercurial were 1/1000 LD_(50),1/100 LD_(50) and 1/10 LD_(50).Results After methylmercury poisoning,amplitudes of the outword potassium currents I_(K(Ca)) were(1.48?0.28),(1.36?0.16) and(1.22?0.13)nA.Compared with control group,the amplitudes in three methylmercury poisoning groups were decreased by 8%,16% and 25%(P

Objective:To observe the curative effect and security of nicardipine combined with metoprolol succinate sustained-release tablet on renal hypertension.Method:65 renal hypertension patients were randomly divided into two groups.The patients in the nicardipine group were treated with nicardipine 80 mg q8h,while the patients in the therapy group were treated with nicardipine 40mg qd and metoprolol succinate sustained-release tablet 47.5-95mg qd for 8 weeks.Their blood pressure,heart rate,hepatic function,renal function,blood glucose and lipid were observed and recorded before and after the treatment.Result:The total efficiency was 74.4%in the controlled group and 88.5%in the therapy group,respectively. There were no obvious changes or obvious adverse reactions in their heart rate,hepatic function,renal function,blood glucose and lipid after the treatment.Conclusion:Nicardipine combined with metoprolol succinate sustained-release tablet is efficient and safe but more efficient than nicardipine alone in the treatment of renal hypertension.

The genes of P53,retinoblastoma (Rb),C-myc and human papilloma virus (HPV) were determined by PCR method in specimens of 33 patients with laryngeal carcinoma and 4 normal laryngeal tissues as a control group.There were 23 males and 10 females,ranging in age from 40 to 11 years old.Results showed that the mutation rate of P53 and Rb gene were 69.69%(23/33) and 48.48%(16/33),respectively;c\|myc gene amplification rate and HPV insertion rate were 58.62% (17/29) and 72.72%(24/33),respectively.There were significant difference(P＜0.05)in comparison between positive and negative expression above these genes.The expression rate were 50.00%(12/24),45.83%(11/24)and 66.67%(16/24)of C-myc,Rb and P53 genes respectively in 24 cases who were HPV positive of laryngeal carcinoma.The positive rates were 73.68%(14/19),63.16%(12/19),57.89%(11/19)and 84.21%(16/19) of HPV,C-myc,Rb and P53,respectively in 19 cases who have heavy smoking (20/day,20 years smoking history).Above results suggested that there were closed relationship in the C-myc gene activation and P53,Rb genes inactivation with smoking and HPV infection.It was believed that carcinogen factors on laryngeal carcinoma was the result of factors,genes and stages interaction.