1.Clinical application of sufentanil and propofol by target-controlled influsion in the elderly patients
Journal of Chongqing Medical University 1986;0(04):-
0.05),but the total of propofol was different(P
2.Propofol anesthesia with target-controlled influsion technic modulated by cerebral state index in the elderly patients with tumor
Journal of Chongqing Medical University 2003;0(06):-
Objective:To study the clinical benefit of propofol anesthesia with target-controlled influsion technic modulated by cerebral state index in the elderly patients with tumor. Methods:A total of 126 ASA Ⅰ or Ⅱ aged65 yrs or older patients underwent gastrectomy and rectal surgery were randomly divided into tow groups(n=63 each):group by target-controlled influsion technic modulated(groupⅠ)and group by target-controlled influsion(groupⅡ). CSI of groupⅠwas 50. Propofol of two groups was administered by TCI at a target blood concertration of 2?g/ml during induction of anesthesia and maintenance of anesthesia,sufentanil of two groups was administered by TCI at a target blood concertration of 1.5?g/ml during induction of anesthesia and of 0.3ng/ml during maintenance of anesthesia. MAP,HR,HRV and CSI of the foundation(T1),intubation(T2),five minutes after intubation(T3),chip(T4),the tumor excision(T5) and the end of surgery(T6) were recorded. And the total of propofol was recorded. Results:MAP at T3,T4 and T5 of groupⅡdecreased obviously compared to that of groupⅠ(P
3.Prophylactic Uses of Ceftriaxone in Pulmonary and Esophageal Surgery:a Cost-ef fectiveness Analysis
Lei JIANG ; Wen GAO ; Xiaofeng CHEN
China Pharmacy 2001;0(08):-
OBJECTIVE:To find out a cost-efficient antibiotic prophylaxis of p ul monary and esophageal surgery by way of pharmacoeconomic analysis METHODS:To c ompare the efficacy and cost between short-term and long-term of prophylactic uses of ceftriaxone in pulmonary and esophageal surgery by randomized controlled study and cost-effectiveness analysis RESULTS:Single-dose ceftriaxone regim en and four-dose ceftriaxone regimen were equally effective in preventing posto perative infections in pulmonary and esophageal surgery,the average cost per pa tients for single-dose ceftriaxone regimen(1 257 84?769 67)yuans was signi ficantly lower than that for four-dose ceftriaxone regimen(1 786 69?652 83 ) yuans,P
4.THE RELATIONSHIP BETWEEN THE COUNTERCURRENT OF PORTAL VEIN AND INTRAHEPATIC CANCER METASTASIS IN PATIENTS WITH HEPATIC CARCINOMA UNDER COLOR DOPPLER FLOW IMAGING
Lei DONG ; Xiaofeng ZHAO ; Lanfe LIU
Medical Journal of Chinese People's Liberation Army 2001;0(07):-
The present study was performed to investigate the relationship between the countercurrent of portal vein and intrahepatic cancerometastasis in patients with hepatic carcinoma under color Doppler flow imaging.To display the situation of portal carcinomatous thrombosis and intrahepatic cancerometastasis, two dimensional ultrasound was carried out in patients with hepatitis hepatocarcinoma and non hepatitis hepatocarcinoma. Also, color Doppler flow imaging was employed to examine the incidence of the pylic countercurrent and the portal vein hepatic artery fistula in four groups: hepatitis hepatocarcinoma group, non-hepatitis hepatocarcinoma group, hepatocirrhosis group and control group. The results showed that the incidences of portal carcinomatous thrombosis,intrahepatic cancerometastasis and the incidences of the countercurrent in portal vein were higher in hepatitis hepatocarcinoma group than those in non hepatitis hepatocarcinoma group ( P
5.Predictive value of NT-proBNP and HCY in patients with essential hypertension complicating left ventricular hypertrophy
Yahong NIE ; Rong ZHANG ; Lei ZHANG ; Xiaofeng MU
International Journal of Laboratory Medicine 2017;38(9):1160-1162
Objective To explore the levels of blood N-terminal pro-brain natriuretic peptide(NT-proBNP) and homocysteine(HCY) and their clinical significance in the patients with essential hypertension(EH) complicating left ventricular hypertrophy(LVH).Methods One hundred and fifty cases of HE were divided into the EH-LVH group and simple EH group according to the results of cardiac ultrasound.One hundred individuals undergoing physical examination were selected as the control group.The levels of blood NT-proBNP and HCY were compared among three groups and the correlation analysis were analyzed with LV was performed.Results The levels of blood NT-proBNP and HCY in the EH-LVH group were obviously higher than those in the EH group and control group,the EH group was significantly higher than the control group,the difference was statistically significant(P<0.05).The levels of blood NT-proBNP and HCY had significantly positive correlation with left ventricular mass index(LVMI),while negative correlation with mitral flow velocity E/A(P<0.05).Conclusion The NT-proBNP and HCY levels can be used as the indicators for monitoring the development and progress of EH and has some predictive value for its complicating LVH.
6.Study on proliferation capability and human telomerase reverse transcriptase expression of bone marrow-derived mesenchymal stem cells from rheumatoid arthritis patients
Jinfang GAO ; Liyun ZHANG ; Xiaofeng LI ; Lei XIN ; Yanli YANG
Chinese Journal of Rheumatology 2014;18(3):155-159,后插1
Objective By comparing the proliferation and the human telomerase reverse transcriptase expression of bone marrow mesenchymal stem cells (BMSCs) from rheumatoid arthritis (RA) patients and normal human to explore the existence of BMSCs defects or variation in RA patients,and whether these cells could be used in autologous transplantation.Methods BMSCs were obtained from bone marrow of eight RA patients and healthy volunteers.The cells were isolated andcultured by gradient centrifugation and adherence cultivation,and the surface markers of BMSCs were identitfied by flow cytometertry.Firstly,BMSCs reproductive activity of the two groups were compared:the auxodrome and cell cycle of BMSCs were measured respectively,then the generation doubling time of cell colony and proliferation index were calculated in order to see whether there was a difference of the proliferation capability between the two groups.Furthermore,the hTERT were measured.Results BMSCs were no significant differences between morphology of RA patients and healthy control group.The cells were obtained proof MSCs by flow cytometry.The difference was not statistically significant (P>0.05),RA group and the healthy control group P3-generation cell population doubling time (4.7±0.3) d,(4.8±0.3) d.The difference was statistically significant (P<0.01),P6 generation of healthy control group cell population has doubling time (5.7±0.4) d,RA group (6.3±0.3) d,buut the group RA BMSCs population doubling time is longer than the healthy control group.The difference was not statistically significant (P>0.05),on one hand of the healthy control group P3 BMSCs proliferation index (17.9±2.1)%,on the other hand RA group is (16.9±2.1)%.The difference was statistically significant (P<0.01).P6-generation BMSCs proliferation index in healthy control group (10.7±1.8)%,RA group (6.2±2.2)%,RA group proliferation index than the control group.The difference was also significant (P<0.01).The healthy control group P6 generation of MSCs hTERT expression was (10.6±1.5),RA group is (3.1±1.0),hTERT RA patients expression is lower compared with normal control group.Conclusion There is no significant difference in the proliferative capacity of the two groups at P3,but the BMSCs proliferation at P6 lags behind in the normal group in RA patients,which inferred that the senescences of the BMSCs of RA patients are earlier than healthy donors.The determination results of hTERT have shown that the difference between the two groups is statistically significant,and it proves that the premature aging may be associated with hTERT expression.
7.Optimization of the Extraction Technology of Total Lignans from Pine Needles of Cedrus deodara by Re-sponse Surface Methodology
Yanping LEI ; Xiaofeng SHI ; Dongyan LIU ; Binli WANG
China Pharmacy 2016;27(7):939-941,942
OBJECTIVE:To optimize the extraction technology of total lignans from pine needles of Cedrus deodara. METH-ODS:Using ethanol volume fraction,ratio of liquid to solid and extraction time as response factor,the content of total lignans as response value,the response surface methodology test was conducted based on Box-Behnken design to optimize the extraction tech-nology of total lignans from pine needles of C. deodara. RESULTS:The optimal extraction technology was as follows as ethanol volume fraction of 78%,ratio of liquid to solid 25∶1,extraction time 1.75 h. The content of total lignans from pine needles of C. deodara was 99.2 mg/g,which was close to predicted value 100.49 mg/g,with relative deviation of 0.65%. CONCLUSIONS:Op-timized extraction technology of pine needles of C. deodara by response surface methodology is feasible and stable,and has good predictability.
8.Experience in the surgical treatment of 16 cases of cardiac rupture caused by blunt chest trauma
Xiaofeng LI ; Jianxin MA ; Jianwei LIU ; Wei LEI
Clinical Medicine of China 2012;28(1):100-101
ObjectiveTo retrospectively analyze the experience in the treatment of cardiac rupture caused by blunt chest trauma and to explore the approaches and methods to improve patient survival.Methods From 2004 to 2010,16 cases of closed chest trauma caused by cardiac rupture,who were treated in our hospital,were treated by heart repair using median sternotomy incision approach.Results Except for 1 patient occurred cardiac arrest before the establishment of CPB,who was failed for cardiopulmonary resuscitation after surgical repair,the remaining 15 patients were all successfully treated.Conclusion The diagnosis of cardiac rupture should be made as soon as possible once it occurs.Timely and decisive rescue and emergency surgery should be given.Heart repair can greatly improve the patient's survival.
9.Changes in stroke volume variation monitored by FloTrac/Vigileo system during mechanical ventilation in patients undergoing pulmonary lobectomy
Xu CHEN ; Lei CHEN ; Xiaofeng ZHANG ; Meiying XU
Chinese Journal of Anesthesiology 2011;31(7):844-846
ObjectiveTo investigate the changes in stroke volume variation (SVV) monitored by FloTrac/Vigileo system during mechanical ventilation in patients undergoing pulmonary lobectomy.MethodsForty-four ASA Ⅰ or Ⅱ patients aged 44-64 yr weighing 47-86 kg undergoing elective pulmonary lobectomy performed under general anesthesia were studied.Blood volume was maintained by fluid (crystalloid∶ colloid 1∶1) infusion at a rate of 6-8 ml·kg-1 ·h-1.Cardiac output index (CI),stroke volume index (SVI) and SVV were measured based on arterial pressure wave form analysis by FloTrac/Vigileo System (Edwards Co.,USA) and recorded at following time points:at 5 min of two-lung ventilation (TLV) in supine position,2 min TLV in lateral position,during one-lung ventilation (OLV) before thoracotomy,at 5 and 30 min of OLV after thoracotomy,1 and 15 min OLV + PEEP of 5cm H2 O,before and immediately and 1 min after reflation of the remaining lobes.The normal value for SVV is less than 13%.ResultsThe hemodynamic parameters were stable during lobectomy.CI and SVI were within normal range.SVV was less than 13% at all time points except that at immediately after reflation of the remaining lobes.ConclusionSVV obtained with FloTrac/Vigileo system can be used to guide fluid therapy during OLV in mechanically ventilated patients undergoing pulmonary lobectomy.
10.Image features of ielocecus under colonoscopy in intussusceptions children after successful reduction
Haifeng LIU ; Xiaofeng XIONG ; Shenglin YUE ; Lei YU ; Maohua HUANG
Chinese Journal of Digestive Endoscopy 2011;28(2):83-86
Objective To investigate the role of ileocecal valve in children patients with intussus-ceptions by colonoscopy after pneumatic air enema reduction. Methods A total of 106 intussusceptions chil dren patients, who recovered with pneumatic air edema reduction, were recruited to the study. They underwent colonoscopy within 12 hours after reduction. The control group was composed of 103 children patients with both diarrhea and hematochezia. There was no significant difference in age, sex or weight between the two groups.Colonoscopic findings were recorded in terms of slack, swelling, prolapsus, lymphoid hyperplasia and mucosal lesions in ileocecal valve. Results In patients with intussusceptions, the rates of ileocecal valve slack, swelling including prolapsus, lymphoid hyperplasia and mucosal lesions were 61.3%, 33. 9%, 100. 0% and 31.1%, respectively, which were significantly different with those of the control group (P > 0. 05 ). When further divided intussusceptions patients into groups with age more than 1 yr or less, significant differences were also observed in regarding of these features. Conclusion There is a close relationship between morphological and functional changes in ileocecal valve and intussusceptions in children. Ileocolic intussusceptions in patients younger than 1yr is more likely to be due to slack of ileocecal valve, while that in patients older than 1yr is mainly due to swelling or prolapse of ileocecal valve, represented by ileocecal intussuception.