1.Decompressive craniectomy and temporal muscle sticking therapy of cerebral infarction:experience and problems
Chinese Journal of Tissue Engineering Research 2014;(11):1793-1798
BACKGROUND:A surgery can relieve the increased intracranial pressure, brain tissue edema, and brain stem compression in patients with massive cerebral infarction, and reduce the risk of serious complications, provide more time for medical treatment, and decrease the mortality and disability rate.
OBJECTIVE:To investigate the clinical value of decompressive craniectomy plus temporal muscle sticking therapy of cerebral infarction.
METHODS:A retrospective analysis was performed among the clinical data of 37 cerebral infarction patients, including 24 males and 13 females, they aged 10-55 years old. After decompressive craniectomy plus temporal muscle sticking therapy, the involved patients were fol owed up. The prognosis was evaluated according to the Glasgow Outcome Scale, as excel ent, good, moderate, none, and poor.
RESULTS AND CONCLUSION:At 6 months of fol ow-up, the total efficiency of surgical treatment in 37 patients was up to 89%, including excel ent in 5 cases (14%), good in 15 cases (41%), moderate in 13 cases (35%), none in 4 cases (11%). No cases exhibited aggravation. Thirty-one patients with cerebral infarction were detected by cranial CT scans, among them 19 patients exhibited significantly reduced infarct size, and 12 patients who had self-care ability were found to restore the cerebral cortex activity. During the 1-year fol ow-up, 31 patients completed the fol ow-up, the remaining 6 cases were lost due to contact failure. Twenty-three cases achieved satisfactory long-term results, and returned to normal work and simple labor, two cases occurred contralateral cerebral infarction and became sicker. Decompressive craniectomy plus temporal muscle sticking therapy is an effective treatment for the majority of cerebral infarction.
2.Surgical therapy of senile gastric cancer complicated with portal hypertension
Chinese Journal of Geriatrics 2012;31(7):593-595
Objective To investigate the surgical treatment method for senile gastric cancer complicated with portal hypertension. Methods Retrospective analysis was used for 88 elderly patients who suffered from gastric cancer complicated with portal hypertension.Among the cases,35 cases were treated with standard radical resection,38 cases treated with cytoreductive surgery,9 cases with palliative operation,and 6 cases cured with jejunal fistula.Operation complications,death and mortality,the risk factors of postoperative complications were observed. Results For all the patients,the operation time was (170±33) min,and the intraoperative bleeding was (490±100) ml.In 35 patients (39.8%) occurred operation complications,among which the incidence of incision infection and anastomotic leakage was the highest, which accounted for 14.3% and 11.4%,respectively.In 5 years,69 patients were in death,the mortality rate was 78.4% which most resulted from liver failure (21.7%).Logistic regression analysis showed that age,tumor diameter,operation time and perioperation bleeding were the risk factors for death ( 95% CI:6.92-13.33,7.39-18.26,11.34 24.85,8.69-19.27). Conclusions The surgical approach for elderly gastric cancer patients complicated with portal hypertension should be chosen carefully,otherwise it will bring serious operation complications,and even endanger the lives of patients.
3.Innovation of logistics human resources management at public hospitals
Chinese Journal of Hospital Administration 2012;28(5):373-375
The author analyzed the present human resources at logistics departments of public hospitals,pointing out the way out for HR innovation,and probing into the practices of changing the management philosophy,in an effort of building a complete hospital logistics HR system,and developing an excellent hospital logistics team.
4.Clinical experience in the treatment of mycoplasma pneumonia using Azithromycin
Chinese Journal of Primary Medicine and Pharmacy 2011;18(22):3043-3044
Objective To study the clinical curative effect of Azithromycin in the treatment of mycoplasma pneumonia.Methods 24 cases of mycoplasma pneumonia hospitalization patients were selected and made full analysis of their medical records.Results 24 acute patients successfully cured through Azithromycin with good clinical curative effect,beginning with symptoms of fevering,coughing,wheezing,and small blisters in lungs,accompanied by external pulmonary manifestations such as diarrhea,myocardial injury and positive results of serum Mb-IgM test.Conclusion Azithromycin in treatment of mycoplasma pneumonia could quickly retum temperature,and reduc hospitalized time.
5.Investigation on the onset and development of the subjective acuity in normal infant
Journal of Chinese Physician 2011;02(z2):22-25
ObjectiveTo investigate the onset of the measurability and the evolution of the subjective acuity in normal infant.MethodsTwo hundred and sixty - four normal infants were measured using the crowded HOTV recognition symbol system for subjective acuity and the closed-circuit operant preferential looking system(COPL) controlled by computer for grating acuity.The onset of measurability and the evolution of the subjective acuity of the normal infant sample were recorded and analyzed.ResultsIn the study part of the infants with 24-month old began to recognize the subjective vision symbols ( 26.32% ).The measurability of subjective acuity of the infant group with 46 months old arrived to 100%.In the infants with 24-months old,the subjective acuity of the right eye was 4.86 ±0.05,left eye was 4.88 ± 0.08.In the infants with 46-months old the subjective acuity was 5.0 for both right and left eyes.According to Logistic regression analysis,the education background of the mother,and the instruction for infant showed the significant influencing factor.ConclusionThe study suggest that the crowded HOTV recognition symbol system controlled by computer provided a method to explore the onset of the subjective vision and the development of the infant.
6.The study on hemodynamics changes of the regions surrounding hematoma in pafients with hypertensive cerebral hemorrhage
Chinese Journal of Postgraduates of Medicine 2010;33(2):21-24
Objective To the expression of cytokines assay in peripheral blood and hematoma fluid of hypertensive cerebral hemorrhage,and the hemodynamic changes in brain tissue around the hematoma by using perfusion computed tomography imaging(PCTT)and immune turbidimetric analysis and analyze its influence on prognosis.Methods Fifty-six cases of hypertensive intracerebral hemorrhage patients were inspected with conventional CT and PCTT,quantitative analysis of hematoma and the contralateral corresponding area around the cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time (MTT),comparing acute and subacute phase CBF,CBV,MTT change.Peripheral blood,hematoma fluid compiement C_3 and C_4 levels were detected.Results In 56 patients with acute phase ipsilateral CBF,CBV,MTT were(19.3 4±3.1)ml/(min·100 g),(1.4 4±0.4)ml/g,(16.5 4±3.1)s,respectively,and in eontralateral were(50.3 4±3.4)ml/(min·100 g),(2.4±1.1)ml/g,(4.8±2.6)s,the corresponding index difference between the two sides were statistically significant(P<0.05).Subaeute phase ipsilateral CBF,CBV,MTY were(29.7±2.1)ml/(min·100 g),(1.9±0.6)ml/g,(8.9±2.7)s,the in contralateral were (48.2±6.3)ml/(min·100g),(2.3±0.7)ml/g,(4.7±1.6)s,the corresponding index difference between the two sides were statistically significant(P<0.05).Subacute phase CBF,CBV,MTT compared with acute phase,the difference Wag statistically significant(P<0.05).Acute and subacute phase of complement C_3 and C_4 in peripheral blood and hematoma fluid content of the differences were statistically significant(P<0.05).Acute and subaeute phase of edema ratios were 0.9 and 0.4,the difference was statistically significant (P<0.05).Conclusions The cerebral blood flow and cerebral perfusion of the brain tissue amund hematoma after the cerebral hemorrhage are decreased.PCTI Can analyze the intracerebral hemodynamic changes of the brain tissue around hematoma after the cerebral hemorrhage,which is helpful to treat hypertensive cerebral hemorrhage and estimate its prognosis.
7.Research on comprehensive satisfaction evaluation for public hospitals
Chinese Journal of Hospital Administration 2009;25(11):780-783
Description of the importance of satisfaction evaluation for public hospitals,and design of the path and study methodology for such an evaluation.This evaluation pools the comments from government regulators,hospital management,hospital staff of doctors,nurses and technicians,patients or physical examination takers,and community residents at large.By means of fuzzy comprehensive evaluation,it built a comprehensive evaluation model for public hospital satisfaction,and carried out applied studies for such a model.
8.Effect of IL-12 antibody on the survival of mouse heart graft
Chinese Journal of Organ Transplantation 2000;21(4):216-217
Objectives To establish the mouse heart transplantation model and observe the effect of anti-rejection of IL-12 antibody.Methods Twenty-five mice undergoing heterotopic heart graft were divided into 4 groups:isograft one(n=5),simple homograft one(n=6),γ-globulin treated one(n=6)and IL-12 antibody treated one(n=8).Results The survival time of cardiac graft in the groups was as follows:> 100 days in isograft group,7.3 days in simple homograft group,7.5 days in r-globulin treated group and 15.4 days in IL-12 antibody treated group.Conclusions A stable mouse heart transplantation modd was established.IL-12 antibody could significantly prolong the survival of mouse cardiac graft and antagonize rejection of organ transplantation.
9.Thrombospondin-1 and taxol resistance
Journal of International Oncology 2010;37(5):341-344
Thrombospondin-1 is known as its anti-angjogenic and proapoptotic activities in oncogenesis. In current research, it has a intimate relationship with taxol resistance. Sensitivity of tumor cells to taxol will descend when the expression:of TSP1 is downregulated,and TSP1 downregulation is mediated by a new gene of taxol-resistance gene 1, the discovery provids a new trend to solve taxol resistance.
10.Effect of intracranial hematoma by drilling skull in treatment of hypertensive brain hemorrhage
Chinese Journal of Primary Medicine and Pharmacy 2009;16(12):2133-2134
Objective To analyze the clinical effect of intracranial hematoma by drilling skull in treatment with hypertensive brain hemorrhage.Methods 188 patients with hypertensive cerebral hemorrhage were classified into control group with 94 cases and traditional group with 94 cases.The control group were treated with conservative medicine and observation group were treated with intracranial hematoma by drilling skull.The clinical efficacy and defection score of nerves function were observed and compared between the two groups.Results The total effective rate in observation group was significantly higher than that in control group(P<0.05) while the death rate in observation group was significantly lower than that in control group (P<0.05),Compared with pre-treatment,after treatment 2 weeks and 4 weeks,the Barthel index in two groups were significantly increased(P<0.05).Moreover,after treatment 2 weeks and 4 weeks,the Barthel index in observation group was significantly higher than that in control group(P<0.05).Conclusion The intracranial hematoma by drilling skull can enhance effective rate,decrease death rate and improve the ADL ability.