Objective To analyze the clinical effect of intracranial hematoma by drilling skull in treatment with hypertensive brain hemorrhage.Methods 188 patients with hypertensive cerebral hemorrhage were classified into control group with 94 cases and traditional group with 94 cases.The control group were treated with conservative medicine and observation group were treated with intracranial hematoma by drilling skull.The clinical efficacy and defection score of nerves function were observed and compared between the two groups.Results The total effective rate in observation group was significantly higher than that in control group(P＜0.05) while the death rate in observation group was significantly lower than that in control group (P＜0.05),Compared with pre-treatment,after treatment 2 weeks and 4 weeks,the Barthel index in two groups were significantly increased(P＜0.05).Moreover,after treatment 2 weeks and 4 weeks,the Barthel index in observation group was significantly higher than that in control group(P＜0.05).Conclusion The intracranial hematoma by drilling skull can enhance effective rate,decrease death rate and improve the ADL ability.

Objective:To compare the effect between benazepril and candesartan combination and single medication in either one of them for treatment of hypertension-combined with microalbuminuria(MCA). Methods:A total of 95 patients were divided into three groups.Benazepril group(n=31),patients were treated with Benazepril 10～20 mg/day;Candesartan group(n=32),patients were treated with Candesartan 4～8 mg/day;and Combination group (n=32),patients were treated with benazepril 10 mg/day and candesartan 4 mg/day.The medication lasted for 8 weeks.Blood pressure(BP),plasma urinary albumin and creatinine ratio(A/C),endothelin-1(ET-1),nitrogen monoxide(NO)and potassium were examined and compared before and after the medication respectively. Results:The levels of BP,plasma A/C and ET-1 were decrease and NO was increased in all three groups(P0.05,respectively). Conclusion:Effect of benazepril and candesartan combination in patients with hypertension-combined microalbuminuria was better than single medication in either benazepril or candesartan.

Objective To study the incidence rate and clinical features of diffuse axonal injury(DAI).Methods 68 cases of diffuse axonal injury of children were analyzed according to Cordoles's diagnosis standard.Results The features of DAI were epilepsy,deep coma,pupil change and vital signs change,with low mortality rate.Conclusion DAI is serious with high incidence rate and good outcome.

Objectives To establish the mouse heart transplantation model and observe the effect of anti-rejection of IL-12 antibody.Methods Twenty-five mice undergoing heterotopic heart graft were divided into 4 groups:isograft one(n=5),simple homograft one(n=6),γ-globulin treated one(n=6)and IL-12 antibody treated one(n=8).Results The survival time of cardiac graft in the groups was as follows:＞ 100 days in isograft group,7.3 days in simple homograft group,7.5 days in r-globulin treated group and 15.4 days in IL-12 antibody treated group.Conclusions A stable mouse heart transplantation modd was established.IL-12 antibody could significantly prolong the survival of mouse cardiac graft and antagonize rejection of organ transplantation.

Thrombospondin-1 is known as its anti-angjogenic and proapoptotic activities in oncogenesis. In current research, it has a intimate relationship with taxol resistance. Sensitivity of tumor cells to taxol will descend when the expression:of TSP1 is downregulated,and TSP1 downregulation is mediated by a new gene of taxol-resistance gene 1, the discovery provids a new trend to solve taxol resistance.

Objective To the expression of cytokines assay in peripheral blood and hematoma fluid of hypertensive cerebral hemorrhage,and the hemodynamic changes in brain tissue around the hematoma by using perfusion computed tomography imaging(PCTT)and immune turbidimetric analysis and analyze its influence on prognosis.Methods Fifty-six cases of hypertensive intracerebral hemorrhage patients were inspected with conventional CT and PCTT,quantitative analysis of hematoma and the contralateral corresponding area around the cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time (MTT),comparing acute and subacute phase CBF,CBV,MTT change.Peripheral blood,hematoma fluid compiement C_3 and C_4 levels were detected.Results In 56 patients with acute phase ipsilateral CBF,CBV,MTT were(19.3 4±3.1)ml/(min·100 g),(1.4 4±0.4)ml/g,(16.5 4±3.1)s,respectively,and in eontralateral were(50.3 4±3.4)ml/(min·100 g),(2.4±1.1)ml/g,(4.8±2.6)s,the corresponding index difference between the two sides were statistically significant(P<0.05).Subaeute phase ipsilateral CBF,CBV,MTY were(29.7±2.1)ml/(min·100 g),(1.9±0.6)ml/g,(8.9±2.7)s,the in contralateral were (48.2±6.3)ml/(min·100g),(2.3±0.7)ml/g,(4.7±1.6)s,the corresponding index difference between the two sides were statistically significant(P<0.05).Subacute phase CBF,CBV,MTT compared with acute phase,the difference Wag statistically significant(P<0.05).Acute and subacute phase of complement C_3 and C_4 in peripheral blood and hematoma fluid content of the differences were statistically significant(P<0.05).Acute and subaeute phase of edema ratios were 0.9 and 0.4,the difference was statistically significant (P<0.05).Conclusions The cerebral blood flow and cerebral perfusion of the brain tissue amund hematoma after the cerebral hemorrhage are decreased.PCTI Can analyze the intracerebral hemodynamic changes of the brain tissue around hematoma after the cerebral hemorrhage,which is helpful to treat hypertensive cerebral hemorrhage and estimate its prognosis.

Description of the importance of satisfaction evaluation for public hospitals,and design of the path and study methodology for such an evaluation.This evaluation pools the comments from government regulators,hospital management,hospital staff of doctors,nurses and technicians,patients or physical examination takers,and community residents at large.By means of fuzzy comprehensive evaluation,it built a comprehensive evaluation model for public hospital satisfaction,and carried out applied studies for such a model.

Objective To investigate the surgical treatment method for senile gastric cancer complicated with portal hypertension. Methods Retrospective analysis was used for 88 elderly patients who suffered from gastric cancer complicated with portal hypertension.Among the cases,35 cases were treated with standard radical resection,38 cases treated with cytoreductive surgery,9 cases with palliative operation,and 6 cases cured with jejunal fistula.Operation complications,death and mortality,the risk factors of postoperative complications were observed. Results For all the patients,the operation time was (170±33) min,and the intraoperative bleeding was (490±100) ml.In 35 patients (39.8％) occurred operation complications,among which the incidence of incision infection and anastomotic leakage was the highest, which accounted for 14.3％ and 11.4％,respectively.In 5 years,69 patients were in death,the mortality rate was 78.4％ which most resulted from liver failure (21.7％).Logistic regression analysis showed that age,tumor diameter,operation time and perioperation bleeding were the risk factors for death ( 95％ CI:6.92-13.33,7.39-18.26,11.34 24.85,8.69-19.27). Conclusions The surgical approach for elderly gastric cancer patients complicated with portal hypertension should be chosen carefully,otherwise it will bring serious operation complications,and even endanger the lives of patients.

The author analyzed the present human resources at logistics departments of public hospitals,pointing out the way out for HR innovation,and probing into the practices of changing the management philosophy,in an effort of building a complete hospital logistics HR system,and developing an excellent hospital logistics team.

Objective To investigate feasibility, efficacy and safety of holmium laser lithotripsy under ureteroscopy to treat ureteral calculi. Methods Clinical data of 162 patients with ureteral calculi treated by holmium laser lithotripsy under ureteroscopy in our hospital from June 2006 to October 2009 were reviewed retrospectively. Stone-broken rate,lithagogue rate and complication were observed. Results The overall rate of successful fragmentation for all levels of ureteral calculi in a single procedure achieved 96. 30% (156/162). The success rates of fragmentation for the upper and mid-lower segment of ureteral calculi was 86.11% (31/36)and 99.21% (125/126),respectively. In 156 patients, the postoperative follow-up of 2- 4 weeks revealed that the stone free rate was 98.08 % (153/156). The mean operative time was (36 ± 11 )mains ( ranged from 15 to 90) and hospital stay ranged from 1 to 10 days. Conclusion Holmium laser lithotripsy under ureteroscopy is feasible,high effective and safe for the treatment of ureteral calculi, especially for those with middle or lower levels ureteral calculi.