Objective To explore the damage effect of formaldehyde on DNA in cells of rats. Methods 24 SD rats were randomly divided into 6 groups, formaldehyde (10, 20, 30, 40 mg/kg), distilled water and cyclophospho acetic acid (as the positive control) were given i.p. 24 hours after treatment. Comet Assay were used to detect DNA damage in the cells of the liver, kidney and lung. Results The DNA damage induced by formaldehyde was found in cells of the three organs and the significant dose-response relationship was demonstrated also. Conclusion Formaldehyde can induce DNA damage in cells of rats. The result of the present paper indicates once again that formaldehyde has genetic toxicity.

Objective To investigate the diagnosis and treatment of high-flow priapism. Methods Five cases of high-flow priapism (age range,18-54 years) were included.Their symptom was described as devoid of pain or tenderness, incompletely but constantly rigid of the penis which was able to increase rigidity with sexual stimulation.Blood taken from the corpora cavernosa showed an arterial blood sample in all the cases.Perineal color Doppler ultrasound findings included the presence of patent cavernous arteries and the focal area of high flow turbulence along the cavernous arteries in 4 cases.Contrast medium extravasating from a lacerated cavernous artery into surrounding erectile tissue lacunae was found when performing internal pudendal arteriography in all the cases.Initially,conservative therapy was attempted but was unsuccessful.Therefore superselective embolization of the proximal artery supplying arterial fistula was carried out in the 5 cases. Results After embolization the penile erection disappeared immediately.In 1 case,priapism recurred 12 h after the embolization and the second embolization was successful and the interval of complete detumescence was 5 to 42 d.The sexual function and erectile rigidity were normalized in 2 weeks to 4 months after embolization.The follow-up time was from 11 to 143 months.The sexual function was completely preserved in all the 5 cases with no recurrence of priapism. Conclusions Intracavernal blood gas analysis,color Doppler ultrasound and internal pudendal arteriography were effective means for the diagnosis of priapism.The effect of superselective embolization of the internal pudendal artery was satisfactory.

Objective To analyze the epidemiological characteristics of mumps in Inner Mongolia Autonomous Region from2015 to 2022,and provide decision making strategy for the control and prevention of mumps.Methods Using SPSS 26.0and Excel 2010 statistical software,the epidemiological statistical description and analysis of mumps cases in Inner Mongolia Autonomous Region from 2015 to 2022 were performed.Results A total of 16 018 cases of mumps were reported in Inner Mongolia Autonomous Region from 2015 to 2022,with an average annual incidence of 8. 274 5/100 000. All cities had reported cases,and the peak incidence was mainly concentrated from April to July and from September to December. The age of the affected population was mainly 0-14 years old,accounting for 90. 14% of the total number of cases,and the affected population mainly included students,preschool children and scattered children.Conclusion From 2015 to 2022,the incidence rate of mumps in Inner Mongolia Autonomous Region showed a downward trend,and the average annual incidence was lower than the national reported level. The epidemic showed an obvious seasonality,and students,kindergarten children and scattered children were the key groups for prevention and control. It is necessary to strengthen the surveillance,prevention and control of mumps in schools,kindergartens and other collective units,and continue to implement the immunization strategy of age-eligible children vaccinated with two doses of mumps-containing vaccine(MuCV).

The test after maintenance can remove such personal factors as bad installation,disqualification of parameter debugging,fault in pipeline,etc.It avoids some malpractice during the treatment.

Objective To explore the personnel framework strategy of multi-disciplinary treatment (MDT) for colorectal cancer. Methods Combined the characteristics of large public hospital, with recognized treatment pathway in international MDT for colorectal cancer and management of medical human resource, colorectal cancer MDT project team summarized a system of multi-disciplinary treatment-working for colorectal cancer of West China Hospital (MDT-CRC-WCH) by own management mechanism and subject feature. Results Based on the main four principles——whole, match, voluntary and interactive, MDT-CRC-WCH constructed reciprocation “concentric circle” with the team of directors, coordinators, colorectal surgeons, related professors, nursing and other assistants.Conclusion With construction of multi-layers, MDT for colorectal cancer is completing MDT personnel framework and suitable layers relation. And how to construct prolong active and innovative system of MDT human resource management needed more research.

Objective To explore the whole constructive conception and organization structure strategy of multi-disciplinary team (MDT) for colorectal cancer (CRC). Methods Combined the characteristics of large public hospital, with recognized treatment pathway in MDT for CRC and the way of medical project construction, MDT for CRC project team summarized a system of MDT for CRC of West China Hospital (MDT-CRC-WCH) by own characteristics and subject feature. Results MDT for CRC summarized the 5 basic characteristics about profession, classification, interaction, optimization and fast. The project has the core competencies: system new operation types for colorectal cancer and volunteer culture. By the matrix organization structure, MDT set the main departments: database team, follow-up team, nursing team and public team. Conclusion With effective MDT whole construction and suitable organization structure, MDT will develop in long time.

Objective The article explained how to build the data system and its running strategy in the mode of multi-disciplinary team (MDT) for colorectal carcinoma. Methods It illuminated the cause of the data system building, also described the essential composition of the data system and how to support the running of the data system, and it discussed the value feedback of the data system, lastly the author proposed the prospect of the data system building. Results The data system could work normally through consultation of doctors, follow-up, clinical support and appropriate implement of construction of information flow-sheet in colorectal carcinoma MDT mode. Conclusion As the foundation of colorectal carcinoma MDT, data system could show both medical and social value through change of medical mode.

Fetal heart rate (FHR) baseline estimation is of significance for the computerized analysis of fetal heart rate and the assessment of fetal state. In our work, a fetal heart rate baseline correction algorithm was presented to make the existing baseline more accurate and fit to the tracings. Firstly, the deviation of the existing FHR baseline was found and corrected. And then a new baseline was obtained finally after treatment with some smoothing methods. To assess the performance of FHR baseline correction algorithm, a new FHR baseline estimation algorithm that combined baseline estimation algorithm and the baseline correction algorithm was compared with two existing FHR baseline estimation algorithms. The results showed that the new FHR baseline estimation algorithm did well in both accuracy and efficiency. And the results also proved the effectiveness of the FHR baseline correction algorithm.
Algorithms ; Female ; Heart Rate, Fetal ; Humans ; Pregnancy ; Reference Values

BACKGROUND: Traditionally, bee venom can treat rheumatic arthritis,rheumatoid arthritis(RA) and so on, but it has strong side effects. So it has been hoped for a long time that the effective angle component could be screened from bee venom, which can be used for the treatment of arthritis perfectly than bee venom.OBJECTIVE: To investigate whether bioactive peptide from bee venom could inhibit infection of arthritis by regulating immunological function so as to probe into a new treatment for RADESIGN: Completely randomized controlled experimental trial based on experimental animalsMETHODS: A municipal key laboratory of animal biology.MATERIALS: The experiment was carried out in the Chongqing Key Laboratory of animal biology from January 2001 to May 2002. Totally 80 rats of clean grade aged 2 to 3 months old with the body mass of 180 to 200 g were provided by Animal Experiment Center of Third Military Medical University of Chinese PLA. The experimental animal certification number was SYXK1 (army) 2002 -007. The animals were divided into 3 groups: normal control group( 10 cases), arthritis group( 10 cases), bioactive peptide group(30 cases).METHODS: Adjuvant-induced arthritis animal models were used and bioactive peptide were given to the animals by muscle injection to observe the knuckle volume and knuckle index changes.MAIN OUTCOME MEASURES: The effect of bioactive peptide from bee venom on the change of knuckle volume and knuckle index in adjuvant-induced arthritis ratsRESULTS: Ten days after injection of 0. 15 mg for each rat, the volume of the paw was (4.72 ±0. 58) mL and the knuckle index was (4.47 ±0.46) mL,which there was significant difference compared with the control group (P＜ 0. 05).CONCLUSION: P-peptide possibly has certain inhibitory effect on the development of the adjuvant-induced arthritis in Wistar rat, and will possibly be a potential therapeutic drug.

Intrauterine infection is one of the most important cause of adverse outcomes in pulmonary diseases among preterm infants.The lung tissues of such infants are still immature, whose contact with pathogens when exposed to intrauterine inflammatory environment may trigger local or even systemic inflammatory response, causing different degrees of harm to fetal or neonatal lung tissue.Such damage could lead to bronchopulmonary dysplasia in preterm infants, neonatal pneumonia, neonatal respiratory distress syndrome, etc., affecting their quality of life.This review is about the research progress and the pathogenesis of intrauterine infection in pulmonary diseases of premature infants.