Bone marrow suppression is one of the common adverse reactions to radiotherapy and chemotherapy. Anticancer treatments such as radiotherapy and chemotherapy first directly damage the patient′s peripheral blood cells, impairing qi and blood; further, they damage the actively proliferating cell populations in the bone marrow, impairing yin and blood; and then they interfere with hematopoietic stem cells, impairing essence and blood. This process is rapid and intense, consistent with the characteristics of " acute deficiency syndrome" , marked by sudden onset, rapid changes, critical condition, complexity and variability, multiple complications, and poor prognosis. Given this, its diagnosis and treatment should differ from those of general deficiency syndromes. This paper advocates the principles and ideas of diagnosis and treatment such as " preventing first and treating early to prevent changes; supplementing for deficiency and strengthening vital qi to eliminate pathogenic factor; urgent rescue for critical conditions, no time to lose; and comprehensive supplementing throughout the process, with severe cases requiring singular action" . This approach is intended to provide theoretical reference and practical guidance for bone marrow suppression after radiotherapy and chemotherapy.

OBJECTIVE To develop a prediction model for durable clinical benefit （DCB） in patients with advanced esophageal squamous cell carcinoma （ESCC） receiving programmed death-1 （PD-1） inhibitor. METHODS The clinical data of patients with advanced ESCC who received PD-1 inhibitor in Jieyang People’s Hospital were retrospectively collected between January 2020 to December 2023. Predictors were screened by least absolute shrinkage and selection operator （Lasso） regression， and a multivariable Logistic regression model was developed to predict DCB. A nomogram was constructed based on the model. Internal validation of the prediction model was performed by using the Bootstrap method， and the model was evaluated by the receiver operating characteristic （ROC） curve， calibration curve， and decision curve analysis. RESULTS A total of 91 patients with advanced ESCC were included. The results of Lasso regression combined with Logistic regression analysis indicated that the baseline lymphocyte monocyte ratio （LMR） [odds ratio （OR）＝1.97， 95% confidence interval （CI）： 1.15-3.36， P＝0.013]， albumin （ALB） content （OR＝1.35， 95%CI： 1.13-1.60， P＜0.001）， body mass index （BMI） category 1 [normal vs. low： OR＝ 0.28， 95%CI （0.09-0.96）， P＝0.042]， BMI category 2 [overweight-obesity vs. low： OR＝0.08， 95%CI （0.01-0.59）， P＝0.013]， and treatment regimen [monotherapy vs. monotherapy combination therapy： OR＝0.07， 95%CI （0.01-0.50）， P＝0.008] were predictive factors for patients with advanced ESCC to achieve DCB when treated with PD-1 inhibitor. A prediction model was constructed based on the above indicators. Internal validation of the model using the Bootstrap method showed an area under the curve of 0.831 （95%CI： 0.746-0.904）， with specificity of 74.4% and sensitivity of 75.0%. The Hosmer-Lemeshow test yielded χ2＝ 9.930， P＝0.270， and the calibration curve slope was close to 1. The decision curve analysis demonstrated that the model exhibited good clinical utility within a threshold range of 0.1 to 1.0. CONCLUSIONS The prediction model based on baseline LMR， ALB content， BMI， and treatment regimen demonstrates robust predictive performance and clinical utility for assessing therapeutic efficacy of PD-1 inhibitor in the treatment of advanced ESCC.

ObjectiveTo study the genetic diversity and genetic relationship of Pinellia ternata germplasm resources and provide the basis for germplasm identification， variety breeding， and resource conservation. MethodIn this study， 27 P. ternata were used as experimental materials to determine seven phenotypic characters， such as plant height， leaf length， and leaf width. Simple sequence repeats （SSR） primers were designed based on P. ternata transcriptome data， and polymerase chain reaction （PCR） amplification was performed on 27 P. ternata samples. The genetic diversity of P. ternata germplasm was analyzed by POPGENE32， PowerMarker V3.25， and NTSYS-PC 2.10e software. ResultA total of 10 pairs of highly polymorphic primers （PIC>0.5） and four pairs of moderately polymorphic primers （0.25

Financial accounting supervision and intemal control can effectively prevent and mitigate economic risks,maintain financial discipline,and improve the efficiency of resource allocation and utilization.They are crucial means to promote the governance system and capability of public hospitals,as well as to ensure their high-quality development.However,how to establish a synergistic mechanism to achieve the coordination of goals,subjects,objects and action and promote the high-quality development of public hospitals,has become an important issue in the operational management of public hospitals.From the perspective of collaborative governance,it elaborates on the theoretical basis of the synergism between financial accounting supervision and internal control.It further explores the construction of acollaborative governance framework,mechanism of action,and implementation path for financial accounting supervision and internal control in public hospitals.It provides theoretical justification and practical references for public hospitals to prevent risks,standardize economic operations,offering new ideas for promoting high-quality development of public hospitals under the new situation.

Financial accounting supervision and intemal control can effectively prevent and mitigate economic risks,maintain financial discipline,and improve the efficiency of resource allocation and utilization.They are crucial means to promote the governance system and capability of public hospitals,as well as to ensure their high-quality development.However,how to establish a synergistic mechanism to achieve the coordination of goals,subjects,objects and action and promote the high-quality development of public hospitals,has become an important issue in the operational management of public hospitals.From the perspective of collaborative governance,it elaborates on the theoretical basis of the synergism between financial accounting supervision and internal control.It further explores the construction of acollaborative governance framework,mechanism of action,and implementation path for financial accounting supervision and internal control in public hospitals.It provides theoretical justification and practical references for public hospitals to prevent risks,standardize economic operations,offering new ideas for promoting high-quality development of public hospitals under the new situation.

Financial accounting supervision and intemal control can effectively prevent and mitigate economic risks,maintain financial discipline,and improve the efficiency of resource allocation and utilization.They are crucial means to promote the governance system and capability of public hospitals,as well as to ensure their high-quality development.However,how to establish a synergistic mechanism to achieve the coordination of goals,subjects,objects and action and promote the high-quality development of public hospitals,has become an important issue in the operational management of public hospitals.From the perspective of collaborative governance,it elaborates on the theoretical basis of the synergism between financial accounting supervision and internal control.It further explores the construction of acollaborative governance framework,mechanism of action,and implementation path for financial accounting supervision and internal control in public hospitals.It provides theoretical justification and practical references for public hospitals to prevent risks,standardize economic operations,offering new ideas for promoting high-quality development of public hospitals under the new situation.

Financial accounting supervision and intemal control can effectively prevent and mitigate economic risks,maintain financial discipline,and improve the efficiency of resource allocation and utilization.They are crucial means to promote the governance system and capability of public hospitals,as well as to ensure their high-quality development.However,how to establish a synergistic mechanism to achieve the coordination of goals,subjects,objects and action and promote the high-quality development of public hospitals,has become an important issue in the operational management of public hospitals.From the perspective of collaborative governance,it elaborates on the theoretical basis of the synergism between financial accounting supervision and internal control.It further explores the construction of acollaborative governance framework,mechanism of action,and implementation path for financial accounting supervision and internal control in public hospitals.It provides theoretical justification and practical references for public hospitals to prevent risks,standardize economic operations,offering new ideas for promoting high-quality development of public hospitals under the new situation.

Financial accounting supervision and intemal control can effectively prevent and mitigate economic risks,maintain financial discipline,and improve the efficiency of resource allocation and utilization.They are crucial means to promote the governance system and capability of public hospitals,as well as to ensure their high-quality development.However,how to establish a synergistic mechanism to achieve the coordination of goals,subjects,objects and action and promote the high-quality development of public hospitals,has become an important issue in the operational management of public hospitals.From the perspective of collaborative governance,it elaborates on the theoretical basis of the synergism between financial accounting supervision and internal control.It further explores the construction of acollaborative governance framework,mechanism of action,and implementation path for financial accounting supervision and internal control in public hospitals.It provides theoretical justification and practical references for public hospitals to prevent risks,standardize economic operations,offering new ideas for promoting high-quality development of public hospitals under the new situation.

Financial accounting supervision and intemal control can effectively prevent and mitigate economic risks,maintain financial discipline,and improve the efficiency of resource allocation and utilization.They are crucial means to promote the governance system and capability of public hospitals,as well as to ensure their high-quality development.However,how to establish a synergistic mechanism to achieve the coordination of goals,subjects,objects and action and promote the high-quality development of public hospitals,has become an important issue in the operational management of public hospitals.From the perspective of collaborative governance,it elaborates on the theoretical basis of the synergism between financial accounting supervision and internal control.It further explores the construction of acollaborative governance framework,mechanism of action,and implementation path for financial accounting supervision and internal control in public hospitals.It provides theoretical justification and practical references for public hospitals to prevent risks,standardize economic operations,offering new ideas for promoting high-quality development of public hospitals under the new situation.