1.Research status of quality assessment of hospice care for children with cancer abroad
Jing WU ; Xianhong ZHANG ; Lu WEI ; Xiaochuan ZHU
Chinese Medical Ethics 2025;38(3):275-280
The effectiveness and professionalism of hospice care services for children with cancer are of great significance for improving their quality of life and reducing the mental and economic burden on their families. Currently, a relatively complete quality evaluation system for hospice care for children with cancer has been established abroad, while research in this field in China is still in its infancy. By elaborating on the concept and connotation of quality assessment of hospice care for children with cancer in detail, systematically reviewing the research status of quality assessment of hospice care for children with cancer abroad, and addressing the problems and challenges faced by quality assessment of hospice care for children with cancer in China, corresponding inspirations and improvement strategies were proposed, aiming to provide a reference for improving the quality of hospice care for children with cancer in China.
2.Effect and mechanism of Jingangteng capsules in the treatment of non-alcoholic fatty liver disease based on gut microbiota and metabolomics
Shiyuan CHENG ; Yue XIONG ; Dandan ZHANG ; Jing LI ; Zhiying SUN ; Jiaying TIAN ; Li SHEN ; Yue SHEN ; Dan LIU ; Qiong WEI ; Xiaochuan YE
China Pharmacy 2025;36(11):1340-1347
OBJECTIVE To investigate the effect and mechanism of Jingangteng capsules in the treatment of non-alcoholic fatty liver disease (NAFLD). METHODS Thirty-two SD rats were randomly divided into normal group and modeling group. The modeling group was fed a high-fat diet to establish a NAFLD model. The successfully modeled rats were then randomly divided into model group, atorvastatin group[positive control, 2 mg/(kg·d)], and Jingangteng capsules low- and high-dose groups [0.63 and 2.52 mg/(kg·d)], with 6 rats in each group. The pathological changes of the liver were observed by hematoxylin-eosin staining and oil red O staining. Enzyme-linked immunosorbent assay was performed to determine the serum levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), alanine transaminase (ALT), aspartate transaminase (AST), tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-18. 16S rDNA amplicon sequencing and metabolomics techniques were applied to explore the effects of Jingangteng capsules on gut microbiota and metabolisms in NAFLD rats. Based on the E-mail:591146765@qq.com metabolomics results, Western blot analysis was performed to detect proteins related to the nuclear factor kappa-B (NF-κB)/NOD-like receptor family protein 3 (NLRP3) signaling pathway in the livers of NAFLD rats. RESULTS The experimental results showed that Jingangteng capsules could significantly reduce the serum levels of TG, TC, LDL-C, AST, ALT, TNF-α, IL-1β, IL-6, IL-18, while increased the level of HDL-C, and alleviated the hepatic cellular steatosis and inflammatory infiltration in NAFLD rats. They could regulate the gut microbiota disorders in NAFLD rats, significantly increased the relative abundance of Romboutsia and Oscillospira, and significantly decreased the relative abundance of Blautia (P<0.05). They also regulated metabolic disorders primarily by affecting secondary bile acid biosynthesis, fatty acid degradation, O-antigen nucleotide sugar biosynthesis, etc. Results of Western blot assay showed that they significantly reduced the phosphorylation levels of NF-κB p65 and NF-κB inhibitor α, and the protein expression levels of NLRP3, caspase-1 and ASC (P<0.05 or P<0.01). CONCLUSIONS Jingangteng capsules could improve inflammation, lipid accumulation and liver injury in NAFLD rats, regulate the disorders of gut microbiota and metabolisms, and inhibit NF-κB/NLRP3 signaling pathway. Their therapeutic effects against NAFLD are mediated through the inhibition of the NF-κB/NLRP3 signaling pathway.
4.Meta-synthesis of qualitative research on decision-making participation experience of parents of terminally ill neonates in NICU
Jing WU ; Xianhong ZHANG ; Lu WEI ; Xiaochuan ZHU
Chinese Medical Ethics 2024;37(10):1213-1221
Objective:To systematically evaluate the qualitative research on the decision-making participation experience of parents of terminally ill neonates in neonatal intensive care unit (NICU).Methods:Qualitative research on the decision-making participation experience of parents of terminally ill neonates in NICU were searched from PubMed,Web of Science,Embase,CINAHL,Cochrane Library,Sinomed,China National Knowledge Infrastructure (CNKI),Wanfang,and VIP databases,with the search period from the establishment of the database to August 2023.The quality of the literature was evaluated using the qualitative research quality evaluation standard of the Joanna Briggs Institute (JBI) in Australia,and the literature was summarized using a synthesizing meta-synthesis method.Results:A total of 13 articles of literature were included,as well as 33 results were extracted and classified into 12 new categories and synthesized into 4 integrative outcomes,including participation tendency,role experience,obstacles,and needs on parental decision-making of terminally ill neonates.Conclusion:Parents of terminally ill neonates in NICU face difficult decision-making choices.Medical staff need to work together with parents to determine their ideal role in decision-making and develop personalized communication content.Society,hospitals,and families need to create a supportive social and psychological environment to provide parents with information and emotional support,as well as improve the coping ability of parents of terminally ill neonates in decision-making.
5.Oblique Lumbar Interbody Fusion Combined With 4-Screw Fixation for Treating Two-Level Degenerative Lumbar Diseases:A Finite Element Study
Ting GE ; Baiwen HU ; Jin XIAO ; Qiaolin ZHANG ; Xiaochuan WU ; Dongdong XIA
Acta Academiae Medicinae Sinicae 2024;46(3):341-347
Objective To demonstrate the feasibility of oblique lumbar interbody fusion(OLIF)com-bined with 4-screw fixation for treating two-level lumbar degenerative diseases.Methods An intact finite element model of L3-S1(MO)was constructed and validated.Then,we constructed the M1 model by simulating OLIF surgery at L3/4 and L4/5 segments on the MO model.By attachment of posterior 4-screw or 6-screw fixation to the M1 model,three 4-screw fixation models(M2-M4)and one 6-screw fixation model(M5)were established.The segmental and overall range of motion(ROM)and the peak von Mises stresses of superior endplate,cage,and posterior screw-rod were investigated under each implanted condition.Results Under the motion modes of forward flexion,backward extension,bilateral(left and right)flexion,and left and right rotation,the L3/4 ROM of M2 model and L4/5 ROM of M3 model increased,while the L3/4 and L4/5 ROM of M4 and M5 models significantly decreased compared with those of M1 model.Under all motion modes,the L4 superior endplate in M2 model and the L5 superior endplate in M3 model showed the maximum peak von Mises stress,and the peak von Mises stresses of L4 and L5 superior endplates in M4 and M5 models were close.The L3/4 cage in M2 model and the L4/5 cage in M3 model showcased the largest peak von Mises stress,and the peak von Mises stresses of cages in M4 and M5 models were close.The peak stresses of internal fixation in M2-M5 models were close.Conclusion Four-screw fixa-tion can replace 6-screw fixation in the OLIF surgery for treating two-level degenerative lumbar diseases.
6.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.
7.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.
8.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.
9.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.
10.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.

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