Objective: To understand the effect of badminton exercise on cervical spine function of college students with neck and shoulder syndrome, and to provide support for college students to effectively prevent the occurrence and treatment of neck and shoulder syndrome. Methods: A total of 50 college students with neck and shoulder syndrome were selected by the college students in Guangxi. The study was divided into the control group(25) and the experimental group(25) (1 student in the control group was deleted because of disease in the process of intervention). The experimental group was offered badminton exercise intervention as a public optional course for 12 weeks. Cervical Vertebral Dysfunction Index Questionnaire and Visual Analogue Scale assessment table were also provided to them before and after the evaluation of cervical function. Results: The scores of cervical spine disorders before the intervention in the experimental group were decreased from (36.3±7.8) points to (20.1±8.6) points after intervention, which was statistically significant (t=6.84, P=0.00). There was no significant difference in the scores of cervical spine disorders before and after intervention in the control group(t=0.09, P=0.93). The pain score of the intervention group before intervention was (4.2±1.2), and the intervention was (2.5±1.2). The difference was statistically significant (t=5.48, P=0.00). In the experimental group, the left lateral flexion, right flexion, flexion, extension, left rotation and right rotation of the cervical vertebrae were significantly higher than those before the intervention (P<0.05). The anterior cervical curvature of the experimental group was (160.2±4.9)°. After intervention, the cervical curvature of the intervention group was (143.1±4.9)°, and the difference was statistically significant (t=12.56, P=0.00). Conclusion Badminton exercise has a good intervention effect on cervical vertebrae function of college students with neck and shoulder syndrome. In the future, intervention can be effectively implemented for better prevention and treatment.

[Objective]To explore the clinical efficacy of Qingre Jiedu Decoction in the treatment of acute mastitis during lactation.[Methods]The clinical data of lactating mastitis patients who presented to the Galactophore Department of Beijing Hospital of Traditional Chinese Medicine,Capital Medical University from January 2019 to December 2020 were retrospectively analyzed.In the treatment group,80 patients received internal decoction;in control group,no decoction was taken.The severity index of mastitis,disease improvement rate,breast pain score,milk patency,nipple cracking condition and traditional Chinese medicine(TCM)systemic symptom score were observed.[Results]There were significant statistic differences in the severity index of mastitis,disease improvement rate,breast pain score,milk patency and TCM systemic symptoms scores(P＜0.05).The therapeutic effect of the treatment group was better than that of the control group.[Conclusion]Qingre Jiedu Decoction can effectively release pain,reduce the size of lumps,release swelling and milk stasis of lactation acute mastitis,and the curative effect is good.

Animals ; Mice ; Spinal Neoplasms/pathology* ; Disease Models, Animal

Chemically defined medium is widely used for culturing mouse embryonic stem cells (mESCs), in which N2B27 works as a substitution for serum, and GSK3β and MEK inhibitors (2i) help to promote ground-state pluripotency. However, recent studies suggested that MEKi might cause irreversible defects that compromise the developmental potential of mESCs. Here, we demonstrated the deficient bone morphogenetic protein (BMP) signal in the chemically defined condition is one of the main causes for the impaired pluripotency. Mechanistically, activating the BMP signal pathway by BMP4 could safeguard the chromosomal integrity and proliferation capacity of mESCs through regulating downstream targets Ube2s and Chmp4b. More importantly, BMP4 promotes a distinct in vivo developmental potential and a long-term pluripotency preservation. Besides, the pluripotent improvements driven by BMP4 are superior to those by attenuating MEK suppression. Taken together, our study shows appropriate activation of BMP signal is essential for regulating functional pluripotency and reveals that BMP4 should be applied in the serum-free culture system.
Animals ; Bone Morphogenetic Protein 4/metabolism* ; Cell Differentiation ; Chromosomal Instability ; Endosomal Sorting Complexes Required for Transport ; Mice ; Mitogen-Activated Protein Kinase Kinases/metabolism* ; Mouse Embryonic Stem Cells/cytology* ; Pluripotent Stem Cells/cytology* ; Signal Transduction ; Ubiquitin-Conjugating Enzymes