1.A Survey about Psychosomatic Symptoms and Related Psychosocial Factors of Nursing Students in Military School
Chinese Mental Health Journal 2002;0(08):-
Objective:To study the relationship between psychosomatic symptoms and psychosocial factors of nursing students in military school.Methods:469 nursing students of a military medical school were investigated by SCL-90,EPQ,PSSS,Coping style inventory and self-esteem scale and so on.Results:Nursing students had lower SCL-90 score than the norm of Chinese female and that of military medical students.Their SCL-90 score correlated with EPQ-E、EPQ-L negatively and EPQ-N、EPQ-P positively.It also correlated with passive coping style positively; with positive coping style,self-esteem negatively.Conclusion:Nursing students of military school have less psychosomatic symptoms than medical students.The influential factors are similar to other populations.
2.Influence of improved ICU checklist on instrument management
Xiaohong ZHANG ; Can ZHANG ; Xiao YU
Chinese Journal of Practical Nursing 2017;33(9):698-700
Objective To observe the Influence of improved ICU checklist on instrument management. Methods Reformed and improved the instrument delivery project in ICU checklist. The transfer situation from November 2014 to April 2015 as the control group.The situation from May to October in 2015 as the observation group.Compared the two groups of items of the transfer situation,the condition of nurses′ mastery of instrument parameters,the number of adverse events associated with the instrument and the satisfaction degree of the doctor on nursing work. Results Experimental instrument handover items in succession rate, incidence of adverse events, the doctor to nurse job satisfaction were 25.3% (278/1098), 6 cases, 93% (27/29), the control group were 59.6% (655/1098), 20 cases, 81% (17/21), the difference was statistically significant (χ2 = 264.868, 7.629, 70.046, P < 0.05 or 0.01). Conclusions Improved ICU checklist on instrument management can effectively promote nurses′mastery of instrument parameters, reduce the occurrence of nursing adverse events, ensure patient safety, improve the doctors′ satisfaction on nursing job, and provide an important basis for nursing safety management department.
3.Research and application of cardiac reserve data processing and information management system
Yu ZHANG ; Xingming GUO ; Shouzhong XIAO
Chinese Journal of Tissue Engineering Research 2010;14(4):641-644
BACKGROUND: Cardiac reserve indicators obtained under quiescent condition are used as evaluating index for cardiac reserve functions. However, most important aspect of cardiac dysfunction in heart failure is not the depressed cardiac performance noted at basal resting states, but rather the loss of cardiac reserve. OBJECTIVE: To develop a data processing and information management system for detecting cardiac reserve indicator with the widely used B mode ultrasound instrument in the ultrasonography field, and to provide guidance for B mode ultrasound instrument perfection. METHODS: General B mode ultrasound instrument as peripherals was connected with the pc by image acquisition card; ultrasound heart image diagnosis and management system including professional heart image acquisition and process and perfect data bank was develop. RESULTS AND CONCLUSION: An efficient and flexible mini picture archiving and communication system system was achieved, which realized image enhancement, geometric parameter measuring, convenient diagnosis report output, archive management and print function. Results demonstrated that with the powerful data process ability of PC, the system could improve the performance of the traditional ultrasound instrument in detecting cardiac reserve, which provide a powerful support for the further study.
4.Establishment of a mouse model of early lung adenocarcinoma
Shiman XIAO ; Yu ZHANG ; Jinwei QIANG
Acta Laboratorium Animalis Scientia Sinica 2015;(3):227-232
Objective To establish a mouse model of early lung adenocarcinoma to serve the imaging studies of early lung adenocarcinoma .Methods Two-hundred and ten 4-week old SPF female Kunming mice were randomly divided into 5 experimental groups (40 mice per group) and 1 control group (10 mice).The mice of experimental groups were subcutaneously injected with a dose of 0.2 ml 1-methyl-3-nitro-1-nitroso-guanidine ( MNNG) solution in concentration of 2.0 mg/mL weekly for 1, 2, 4, 8, 12 weeks (group A-E), respectively, while the mice of control group was subcutane-ously injected with 0.2 mL saline weekly for 12 weeks.Ten mice were randomly sacrificed from each experimental group at the 60th, 80th, 100th and 120th days after initial injection ( group A60 , group A80 , group A100 , group A120; group B60 ,……and so on) , and the bilateral lungs were dissected .The tumor occurrence rate , number and size of lung tumors were observedandrecorded.Results 1.Thetumoroccurrencerateandnumberoflungtumorswerepositivelyproportionalto the time and dose of MNNG injection .No tumor was found in any group at the 60th day.2.At the 80th day, the tumor oc-currence rate in the groups A, B, C, D and E was 0, 10%, 30%, 40%and 50%, respectively.The number of tumors in each group was 0, 4, 42, 60 and 81, respectively.The number of tumors smaller than 0.5 mm in diameter was 0, 4, 25, 31 and 40, respectively.3.At the 100th day, the tumor occurrence rate was 20%, 40%, 100%, 100%and 100%, re-spectively.The number of tumors was 6, 19, 187, 223 and 301, respectively, and the number of tumors smaller than 0.5 mm in diameter was 5, 16, 132, 124 and 123, respectively.4.At the 120th day, the tumor occurrence rate was 30%, 50%, 100%, 100%and 100%, respectively.The number of tumors was 30, 124, 302, 351 and 362 per group, respec-tively.The number of tumors smaller than 0.5 mm in diameter was 21, 98, 123, 140 and 108, respectively.The induced lung adenocarcinomas were confirmed by pathology .Conclusions MNNG solution 0.2 mL (2.0 mg/mL) subcutaneously injected weekly for 4 weeks can produce 100%occurrence rate of lung adenocarcinoma in mice and most tumors are smaller than 0.5 mm in diameter at 100th day after initial injection .It is a most suitable model for imaging studies of mouse early lung adenocarcinoma .
5.Effects of CMTM5 on EG-VEGF in prostate cancer cells
Yasheng HUANG ; Xiao ZHANG ; Qiqi YU
Chinese Journal of Endocrine Surgery 2015;(6):464-467
Objective To investigate the effect of CKLF-like MARVEL transmembrane domain contai-ning member 5(CMTM 5)on EG-VEGF expression in prostate cancer cells , and to detect the potential mechanism of CMTM5 inhibiting prostate cancer .Methods The relative expression of CMTM 5 and EG-VEGF in prostate cells and prostate cancer cells was detected .Prostate cancer cells were given Plasmid transfection to overexpress CMTM5 and EG-VEGF expression was again detected .Then CMTM5 and EG-VEGF were compared between be-fore and after CMTM5 plasmid transfecting prostate cancer cells .Results Compared with the relative expresion of EG-VEGF and CMTM5 in prostate cells , prostate cancer cells showed high expression of EG-VEGF and low ex-pression of CMTM5, which were statistically significant , P<0.05.Compared with prostate cancer cells , the rela-tive expression of CMTM5 were obviously upregulated and EG-VEGF obviously decreased in prostate cancer cell after transfected by CMTM5 plasmid, which were statistically significant , P<0.05.Conclusions Prostate canc-er cells shows higher EG-VEGF expression and lower CMTM 5 campared with normal prostate cells .EG-VEGF is suppressed significantly when the prostate cancer cell is transfected by CMTM 5 plasmid and shows highlevel of CMTM5 expression , suggesting high expression of CMTM 5 may inhibit the development of prostate cancer by downregulating EG-VEGF expression .
6.Diagnostic evaluation of serum P53 antibody concentration in lung cancer patients
Xiaofeng ZHANG ; Hualong XIAO ; Jingfeng YU
International Journal of Laboratory Medicine 2006;0(11):-
Objective Statistically analyze the serum P53 antibody level in lung cancer patients to show its diagnostic values.Methods 53 cases of lung cancer and 32 cases of lung cancer after operation and chemotherapy are used as study group. 34 normal controls and 35 cases of lung benign disease were used as control group. All the serum P53 antibody levels of the testees are measured with a ELISA kit.Results In 53 cases of lung cancer group, the positive rate was 58.5% (31/53), while the average serum P53 antibody level was (4.551?6.074)IU/ml. In 32 cases of lung cancer after treatment including surgical and medical procedures, the positive rate was 25% (8/32), while the average serum P53 antibody level was (1.086?2.836)IU/ml. In 35 cases lung benign disease group, the average serum P53 antibody level was (0.163?0.097)IU/ml. In normal group, the average serum P53 antibody level was (0.162?0.08)IU/mL.The lung cancer group had statistical significance in comparison with the other three groups (P0.05).Conclusion The P53 antibody′s appearance is highly correlated with lung cancer. It can be used as an important marker of lung cancer and be beneficial to the differential diagnosis of lung lesions and the evaluation of the treatment.
7.A clinical study on the interventional treatment of acute pulmonary embolism
Xixiang YU ; Minghua ZHANG ; Xiao CI
Journal of Interventional Radiology 1994;0(02):-
Objective To evaluate the effectiveness of interventional procedures in the treatment of acute pulmonary embolism(PE). Methods Pulmonary arterial thrombolytic therapy, suction and fragmentation of thromhi, anti-spasm, and balloon dilation were performed in eighteen cases with clinically highly suspected PE confirmed by emergent pulmonary artery angiography beforehand. Wedged pulmonary arterial pressure, pulmonary recanalization rate, the display ratio of distal pulmonary capillary net, blood gas analysis, blood oxygen saturation, and the improvement of clinical symptoms and signs were used for evaluation of the effectiveness. Seventeen of the alive cases with dislodgement of deep vein thrombi of the lower extremities were confirmed for the formation of PE and then thrombolytic treatment of the thrombotic deep vein was performed after the placement of inferior vena cava filter. Results Pulmanory artery angiographies showed embolism of the pulmonary arterial trunks or more than two of the branches. The post-treatment pulmonary patency reached 80%-90% in three cases, 90%-95% in eleven cases and 100% in five cases. The display ratio of distal pulmonary capillary net was over 90% in all the cases. Wedged pulmonary arterial pressure decreased to below 25 mmHg in thirteen cases, and to 25-30 mmHg in five cases. Blood oxygen saturation rate improved immediately to 90%-95% in ten cases and to 95%-100% in eight cases. Cough, hemoptysis, dyspnea, and chest pain were completely relieved in thirteen cases and significantly relieved in five cases. Digestive track bleeding was complicated in one case. Conclusions Pulmonary artery angiography is the golden standard for the diagnosis of pulmonary embolism. Interventional therapy is very effective for acute pulmonary embolism, which can significantly reduce the mortality rate.
8.Preliminary construction of nursing care quality index in ophthalmology
Yu ZHANG ; Qiongman YANG ; Huiming XIAO
Chinese Journal of Practical Nursing 2017;33(23):1792-1794
Objective To explore the preliminary construction of nursing care quality index based on the characteristics of ophthalmic nursing. Methods Through literature review and experts′discussion, the preliminary construction of nursing care quality index were designed. The Delphi method was used to revise the indicators. Results After two rounds of Delphi procedure, the opinion of the experts became consistent. Questionnaire collecting rates of the two rounds were both 100%, and cooperation index were 0.236 and 0.292 respectively (P<0.01), two first level quality indicators were confirmed, namely ophthalmic care operations (five second level indicators) and health education (four second level indicators). Conclusion The ophthalmic nursing care quality indicators were scientific, reliable and feasible, which could provide objective and quantified basis for the management of nursing care quality.
9. Clinical study of Xihuang Capsule combined with albumin paclitaxel in treatment of advanced triple negative breast cancer
Chinese Traditional and Herbal Drugs 2020;51(24):6324-6327
Objective: To investigate the clinical effect of Xihuang Capsule combined with albumin paclitaxel in the treatment of advanced triple negative breast cancer. Methods: A total of 80 patients with advanced triple negative breast cancer admitted to Cangzhou Central Hospital were selected as the study subjects. All patients were randomly divided into the control group and the treatment group, with 40 patients in each group. Patients in the control group were given albumin paclitaxel for a cycle of 21 d, and received continuous treatment for at least three cycles. The difference between the treatment group was given six capules of Xihuang Capsules twice a day for one course of treatment for 21 d based on the treatment of control group. The clinical effects of the two groups were compared and analyzed. The KPS and VAS scores of the two groups of patients were evaluated, and the tumor markers and the incidence of adverse reactions after taking the drug were recorded for statistical analysis. Results: After treatment, the objective remission rate (ORR) was 60.0% in the control group and 75.0% in the treatment group. The disease control rate (CBR) was 77.5% in the control group and 85.7% in the treatment group. The difference between the two groups was statistically significant (P < 0.05). After treatment, KPS score and VAS score in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, CA-153 and CEA levels of tumor markers in both groups were significantly lower than those before treatment (P < 0.05), while CA-153 and CEA levels in the treatment group were lower than those in the control group (P < 0.05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion: Xihuang Capsule combined with albumin paclitaxel has higher clinical efficacy and safety in patients with advanced triple negative breast cancer.
10.The role of autophagy in pulmonary inflammatory response in silicosis model rats
zhang yu ; geng xiao ; sai linlin
China Occupational Medicine 2022;49(2):153-157
Objective To evaluate the role of autophagy in inflammatory response in the lungs of silicosis rats. Methods The
specific pathogen-free healthy male Wistar rats were randomly divided into four groups with 10 rats in each group. The rats in the
control group were given an equal volume of 0.9% sodium chloride solution; all rats in the silicon dioxide (SiO2
) group, the SiO2
+
3-methyladenine (3-MA) group, and the SiO2
+rapamycin (RAPA) group were given a mass concentration of 0.05 mg/L of SiO2
suspension (1.0 mL/rat) to establish a rat model of silicosis using non-exposed tracheal instillation method. Two days before
SiO2 exposure, the rats in SiO2
+3-MA group were intraperitoneally injected with 3-MA at a dose of 2.5 mg/kg body weight. The rats
in the SiO2
+RAPA group were intraperitoneally injected with a dose of RAPA 1.0 mg/kg body weight, once a day, and once every
other day after modeling, for a total of 10 injections. The pathological changes in the lung tissue of the rats in each group were
evaluated using hematoxylin-eosin and Masson staining. The relative expression levels of transforming growth factor-β (TGF-β) ,
interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in the lung tissue of the rats in each group were detected using
enzyme-linked immunosorbent assay. The relative expression levels of microtubule-associated protein 1 light chain 3 (LC3) and
yeast autophagy-related gene 6 (Beclin1) in lung tissue of rats in each group were detected by Western blotting. Results The
pathological observation of rat lung tissue showed that scattered inflammatory nodules and interstitial inflammatory cells were
found in the lung tissue of the rats in the SiO2 group. In the SiO2
+3-MA group, the inflammation in the lung tissue was more
severe and the alveolar cavity had viscous secretions. The rats in the SiO2
+RAPA group had less inflammation and smaller
inflammatory nodules than the SiO2 group. Compared with the control group, the TNF-α, IL-1β, TGF-β, Beclin1 protein relative
expression levels and LC3 Ⅱ/Ⅰ ratio in the lung tissue were increased in the SiO2 group (all P<0.05). Compared with the SiO2
group, the relative expression levels of TGF-β and TNF-α in the lung tissue of the rats increased (all P<0.05), and the ratio of
LC3 Ⅱ/Ⅰ and Beclin1 protein relative expression decreased in the SiO2+3-MA group (all P<0.05). Compared with the SiO2+
3-MA group, the relative expression levels of TNF- α, IL-1β and TGF- β in the lung tissue of the SiO2
+RAPA group were
decreased (all P<0.05), and the LC3Ⅱ/Ⅰ ratio and the relative expression level of Beclin1 protein were increased (all P<0.05).
Conclusion Autophagy occurs when inflammatory reaction occurs in the lungs of silicosis model rats; autophagy has inhibitory
effect on pulmonary inflammation.