1.The dissemination of CMV in urine of different group from Guangxi and the relationship between CMV infection and renal disease.
Zhi-ping CHEN ; Hao-bin CAI ; Yu HE ; Shan LI ; Li-lan WANG ; Xiao-xia LAO ; Tai-jie LI ; Chun-hui HU ; Yan DENG ; Jin-yao QIN ; Jian WANG ; Jing YANG ; Yan-hua YANG
Chinese Journal of Experimental and Clinical Virology 2010;24(3):196-198
OBJECTIVETo detect Human Cytomegalovirus (HCMV) DNA in urine samples from the following groups: pregnant women, sick newborns, hospitalized nephropathy patients, renal transplant recipients and normal population. Preliminarily study the relationship of HCMV infection and renal disease.
METHODSTo detect HCMV DNA in morning urine samples by Real-time fluorescence quantitative PCR (FQ-PCR).
RESULTSThe positive rates of HCMV DNA in the urine of pregnant women,sick newborns, hospitalized nephropathy patients, renal transplant recipients and normal population are 8.18%, 3.45%, 18.54%, 25.42%, 0.56%.
CONCLUSIONThe infection rates of HCMV in the urine of pregnant women and sick newborns are very high in Guangxi, it should take serious measures to prevent and control the situation. HCMV probably participate in the injury of kidney, and worsen the disease. It should be one of the causes of renal disease.
China ; Cytomegalovirus ; pathogenicity ; physiology ; Cytomegalovirus Infections ; complications ; epidemiology ; transmission ; DNA, Viral ; analysis ; Ethnic Groups ; Female ; Humans ; Infant, Newborn ; Kidney Diseases ; complications ; epidemiology ; Kidney Transplantation ; Methotrexate ; pharmacology ; Polymerase Chain Reaction ; Pregnancy
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