1.Alveolar soft part sarcoma of the larynx: a case report.
Hao XIAO ; Hui YANG ; Huan WANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(13):1221-1223
Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcomas, this sarcoma occurs rarely in the larynx. Herein, we describe an unusual case of ASPS occurring in the larynx. The patient was a 46-year-old woman who presented with a more than 2-year history of right pyriform fossa mass and progressive hoarseness for three months. The endoscopic examination of the larynx revealed a mass in the right pyriform fossa with smooth surface and well-defined margin. Computed tomography demonstrated a heterogeneous tumor in the right pyriform fossa, and involving the paralaryngeal space, measuring approximately 2.1 cm x 1.7 cm x 2.6 cm, which was resected via lateral neck approach. Histopathology and immunohistochemistry revealed an ASPS. To ours knowledge, this is the first reported case of ASPS arising in pyriform fossa.
Female
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Hoarseness
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Humans
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Immunohistochemistry
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Larynx
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pathology
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Middle Aged
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Sarcoma, Alveolar Soft Part
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pathology
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Tomography, X-Ray Computed
4.Effect of Peitu Shengjin Recipe on Nutritional States and Immune Functions of Stable Phase COPD Patients.
Jing GONG ; Ning CHEN ; Xiao-mei HAO ; Hui LI
Chinese Journal of Integrated Traditional and Western Medicine 2015;35(5):534-536
OBJECTIVETo explore the effect of Peitu Shengjin Recipe (PSR) on nutritional states and immune functions of stable phase chronic obstructive pulmonary disease (COPD) patients.
METHODSTotally 62 stable phase COPD patients were randomly assigned to the treatment group (30 cases) and the control group (32 cases). All patients inhaled Seretide (50/500 µg), twice per day. Besides, patients in the treatment group additionally received PSR, one dose per day. After three months of treatment, the COPD assessment test (CAT) score, the index of nutritional states [including body mass index (BMI) , thickness of skin fold (TSF), mid-arm muscle circumference (MAMC), serum albumin, serum prealbumin], and immune functions (including IgA, IgM, and IgG) were compared between the two groups.
RESULTSBy the end of the treatment, the CAT score decreased more obviously in the treatment group than in the control group (P < 0.05). The improvement of BMI, TSF, MAMC, serum albumin, and serum prealbumin was better in the treatment group than in the control group (P < 0.05). IgM and IgG also increased more in the treatment group (P < 0.05). There was no statistical difference in IgA between the two groups (P > 0.05).
CONCLUSIONSAdditionally use of PSR could improve nutritional states and immune functions of stable phase COPD patients to some extent. Meanwhile, it also could improve their health related quality of life.
Body Mass Index ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Nutritional Status ; Pulmonary Disease, Chronic Obstructive ; drug therapy ; immunology ; Quality of Life ; Serum Albumin
5.The measurement of the third-order branches of the mesenteric artery tone by microvascular ring technique.
Hao LI ; Su-Li ZHANG ; Yan YANG ; Xiao-Rong ZENG ; Hui-Rong LIU
Chinese Journal of Applied Physiology 2014;30(3):214-217
OBJECTIVEIn our study, the function of the third-order branches of the mesentenc artery was measured by microvascular ring technique, which can be used to detect microvascular function in some disease related to microvascular dysfunction.
METHODSIsolated, fixed, standardized and then activated the third-order branches of rat mesenteric artery. Microvascular tone was measured by systolic and diastolic drags respectively, with the help of DMT tension apparatus and PowerLab data acquisition system.
RESULTSThe third-order branches of rat mesenteric artery showed excellent response to vasoactive drugs. The contraction effect of norepinephrine (NE) reached 19 in mN. When acetylcholine (Ach) or sodium nitroprusside (SNP) of 10(9)-10(5)mol/L was added, vascular tones showed gradient drop: 80% of maximal relaxation when adding ACh, while 95% of maximal relaxation when adding SNP.
CONCLUSIONThe third-order branches of the mesenteric artery function was successfully detected by using microvascular ring technique.
Acetylcholine ; pharmacology ; Animals ; In Vitro Techniques ; Male ; Mesenteric Arteries ; drug effects ; physiology ; Nitroprusside ; pharmacology ; Norepinephrine ; pharmacology ; Rats ; Vasoconstrictor Agents ; pharmacology ; Vasodilation ; physiology ; Vasodilator Agents ; pharmacology
6.Quality of life assessment and the related factors of patients with active ankylosing spondylitis
Xiao-Hu DENG ; Feng HUANG ; Hui-Qin HAO ; Li-Sha WANG ; Ya-Mei ZHANG ;
Chinese Journal of Rheumatology 2003;0(08):-
Objective To analysis the quality of life of patients with active ankylosing spondylitis (AS).Methods The quality of life was assessed in 52 patients with active AS using SF-36 and was compared with the general population.The correlation between the quality of life and the clinical measures of disease,in- cluding the Bath AS disease activity index(BASDAI),Bath AS functional index(BASFI),Bath AS metrology index(BASMI),patient's global assessment(PGA),spinal inflammation,total back pain,nocturnal back pain, and enthesis index(EI),were determined.Results The patients with active AS reported significant decreased scores on all dimensions of SF-36.The score of physical health components was poorer than that of mental health components.BASFI was the strongest factor correlated with the score of SF-36,followed by BASDAI and PGA.BASMI and total back pain were correlated with three dimensions only.In multivariate regression analysis,BASFI showed relative closer relationship to the qulity of life with active AS than other clinical mea- sures of disease and it accounted for 50.3%,35.2% and 47.9% of the variance in the physical health compo- nents,the mental health components and the overall score of SF-36,respectively.Conclusion The quality of life in patients with active AS is significantly declined compared with general population.The physical aspects seem to be more severely affected.Functional status of the patients with active AS are correlated with the quality of life closely.
7.Study on relationship between vascular endothelial growth factor and tumor burden
Chinese Journal of Immunology 2018;34(6):906-910
Objective:To investigate the relationship between vascular endothelial growth factor ( VEGF ) and tumor burden. Methods: 100 cases of healthy volunteers,high risk of malignancy (family history of malignant tumors),without site lesions in patients with malignant tumor after operation,patients with stable disease after treatment,newly diagnosed malignancies were enrolled respectively,and recorded as control group,high-risk group,operation group,stable group and newly diagnosed group. The serum VEGF levels in the groups were quantitatively detected respectively,and the peripheral blood CD4+and CD8+were measured,then the CD4+/CD8+was calculated. The increasing rates and grading of VEGF, the serum VEGF levels and the CD4+/CD8+values were compared. Results: There was a significant difference in serum VEGF classification among the groups (P<0. 05). The increasing rates of serum VEGF and the serum VEGF levels in the high-risk group,the operation group,the stable group and the newly diagnosed group were much higher than those in the control group (P<0. 05),of which the CD4+and CD4+/CD8+values were much lower than those in the control group ( P<0. 05) . The increasing rates of serum VEGF and the levels of serum VEGF in the operation group,the stable group and the newly diagnosed group were much higher than those in the high-risk group (P<0. 05),of which the CD4+and CD4+/CD8+values were much lower than those in the high-risk group (P<0. 05). The increasing rates of serum VEGF and the levels of serum VEGF in the stable group and the newly diagnosed group were much higher than those in the operation group (P<0. 05),of which the CD4+and CD4+/CD8+values were much lower than those in the operation group (P<0. 05). The increasing rates of serum VEGF and the level of serum VEGF in the newly diagnosed group were much higher than those in the stable group (P<0. 05),of which the CD4+and CD4+/CD8+value were much lower than those in the stable group (P<0. 05). The CD4+levels in the stable group and the newly diagnosed group were much lower than those in the control group,high-risk group,operation group (P<0. 05). In the newly diagnosed group,serum VEGF level was negatively correlated with CD4+/CD8+(r=-0. 578,P<0. 05). Conclusion: The level of serum VEGF in patients with malignant tumor increase in varying degrees,which also has certain relationships with cellular immune function,and it has reference value to determine the effect of the control of the tumor.
8.Study on in vivo pharmacokinetics of cucurbitacin injection in rats.
Xiao-Ting XU ; Zhi-Peng DENG ; Hui-Xia FAN ; Hao ZHONG ; Qing-Qiang YAO
China Journal of Chinese Materia Medica 2014;39(11):2126-2130
To establish a method for the determination of cucurbitacin in plasma samples, in order to study the in vivo pharmacokinetic characteristics of cucurbitacin in rats. Rats were intravenously injected with cucurbitacin. With diphenhydramine as the internal standard (IS), the plasma concentrations of cucurbitacin in rat plasma at different time points were determined by liquid chromatography tandem mass spectrometry (LC-MS/MS). With electrospray ionization source, the positive ion detection in the multiple reaction monitoring mode was conducted to determine the ion-pairs for target compound and IS were m/z 503.2/113.1 and m/z 256.0/167.2, respectively. Agilent ZOBAX SB-C18 column (2.1 mm x 50 mm, 1.8 microm) was adopted and eluted with methanol and 0.1% formic acid (55:45), and the flow rate was 0.2 mL x min(-1). DAS 2.0 software was applied to fit the blood concentration and calculate corresponding pharmacokinetic parameters. The rats were intravenously injected with cucurbitacin at the concentration of 3.0 mg x kg(-1). The target blood quality concentration show good linear relations within the range of 10.5-3 150 microg x L(-1) (R2 = 0.996), the lower limit of the standard curve was 10.5 microg x L(-1), and the signal to noise ratio S/N = 12. Intra- and inter-day precisions RSD was less than 6.9% and 14%, respectively; The accuracy RE ranged between 0.20% and 3.7%; The extraction recoveries ranged between 92.7% and 97.1%. Regarding the pharmacokinetic parameters of tail intravenous injection of cucurbitacin, AUC (0-t) was (811.615 +/- 111.578) microg x h x L(-1), (t1/2) was (1.285 +/- 1.390) h, CL was (3.627 +/- 0.487) L x h x kg(-1), and V(d) was (6.721 +/- 7.429) L x kg(-1). In this study, researchers established a simple, accurate, sensitive and highly specific method for determining the blood concentration of cucurbitacin, and reported the in vivo pharmacokinetic characteristics of cucurbitacin in rats for the first time.
Administration, Oral
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Animals
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Cucurbitaceae
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chemistry
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Cucurbitacins
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administration & dosage
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blood
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pharmacokinetics
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Drugs, Chinese Herbal
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administration & dosage
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pharmacokinetics
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Male
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Rats
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Rats, Wistar
9.Comparative pharmacokinetics of syringin, eleutheroside E and isofraxidin in rat plasma after intravenous administration of each monomer and Ciwujia injection.
Hui-Xia FAN ; Zhi-Peng DENG ; Hao ZHONG ; Xiao-Ting XU ; Qing-Qiang YAO
China Journal of Chinese Materia Medica 2014;39(10):1921-1927
To compare the pharmacokinetics of syringin, eleutheroside E and isofraxidin after intravenous administration of each monomer and Ciwujia injection. Twenty-four Sprague-Dawley rats were randomly divided into four groups and intravenously administrated with syringin, eleutheroside E, isofraxidin, and Ciwujia injection, respectively. The concentrations of the three components in rat plasma were determined by LC-MS/MS. DAS 2.0 software was applied to calculate the pharmacokinetic parameters while the SPSS 17.0 software was used for statistical analysis. Significant difference (P < 0.05) was found between each monomer and the injection on the main pharmacokinetic parameters such as AUC, CL and t1,/2. Compared with the injection, the group treated with the syringin has obvious decrease in AUC, and increase in CL while the group treated with eleutheroside E has obvious increase in AUC, and decrease in CL The t1/2 of isofraxidin was prolonged in Ciwujia injection. Pharmacokinetic characters of the ingredients in the injection varied greatly from the monomer. Other constituents in the injection may have an impact on the pharmacokinetic profiles of these three components.
Administration, Intravenous
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Animals
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Coumarins
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administration & dosage
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blood
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pharmacokinetics
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Drugs, Chinese Herbal
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administration & dosage
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pharmacokinetics
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Glucosides
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administration & dosage
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blood
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pharmacokinetics
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Lignans
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administration & dosage
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blood
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pharmacokinetics
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Male
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Phenylpropionates
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administration & dosage
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blood
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pharmacokinetics
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Rats
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Rats, Sprague-Dawley
10.Voice Fatigue test in Primary School Teachers in Chengdu and the Potential Impacts on the Voice Health Care
Dan LV ; Hui YANG ; Yanan XU ; Jiao ZHU ; Jian ZOU ; Jun LIU ; Yitao ZHENG ; Hao XIAO
Journal of Audiology and Speech Pathology 2016;24(5):465-468
Objective To investigate the prevalence of voice disorder and voice fatigue mental state in the pri-mary school teachers in a district of Chengdu.Methods A random sampling survey included 389 teachers from a dis-trict of Chengdu after they filled out the throat symptoms questionnaire,carried out voice fatigue tests,and strobo-scopic laryngoscopy.Results The most common voice of discomfort symptoms was hoarseness,followed by sore throat,dry throat and vocal fatigue.There were 189 teachers,48.5%,with voice disorders as the voice disorder group)and 200 teachers without throat and voice disorders as the control group.The failure rate was significantly higher at 80 dB than 75 dB,and for the study group,the failure rate was higher than that of the control group.The difference was statistically significant in 1,2 and 10 minutes between the two groups(P <0.05).Conclusion Voice fatigue is very common in the primary school teachers and when high volumes are required,the voice fatigue is more serious.To reduce voice fatigue and the incidence of primary school teachers'voice disease,we should strengthen the teacher's voice health care.