1.New progress of anti-CD20 monoclonal antibody therapy for children with idiopathic refractory nephrotic syndrome
Journal of Medical Postgraduates 2017;30(3):315-318
Idiopathic Refractory Nephrotic Syndrome (IRNS) has been an intractable problem in clinical treatment .Anti CD20 monoclonal antibody is a new type of immunosuppressive agent , which can induce the lysis and apoptosis of B cells .Significant-ly, it improves the prognosis of IRNS patients .In recent years, a number of case studies and clinical trials have been conducted on the effectiveness of anti CD20 monoclonal antibody in the treatment of children with IRNS .In this paper, the mechanism, clinical applica-tion, adverse effects and problems in the study of anti CD 20 monoclonal antibody in IRNS will be reviewed .
2.Effect of AcSDKP on the expression of MMP-1, MMP-2 and MMP-9 in cardiac fibroblast mediated by TGF-beta.
Xiao-Jun WANG ; Fang YANG ; Li LIU
Chinese Journal of Applied Physiology 2008;24(4):404-425
Animals
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Animals, Newborn
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Cells, Cultured
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Fibroblasts
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cytology
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metabolism
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Matrix Metalloproteinase 1
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metabolism
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Matrix Metalloproteinase 2
;
metabolism
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Matrix Metalloproteinase 9
;
metabolism
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Myocardium
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cytology
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metabolism
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Oligopeptides
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physiology
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Rats
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Rats, Wistar
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Transforming Growth Factor beta
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pharmacology
3.Application of B-mode Ultrasound before Laparoscopic Cholecystectomy
Yueming FANG ; Decai LI ; Xiao YANG
Chinese Journal of Ultrasonography 1995;4(4):154-156,插页36
According to the ultrasonic manifestations of the gall bladder before laparoscopic cholecystectomy(LC),including size,morphology,wall thickness,presence or absence of gallstone,congenital anomaly of biliary duct,surrounding adhesion and state of common bile duct,tbe patients Werc dividcd into 4 groups:A.Most suitable for LC,B.Sitable for LC,C.Relatively suitable for LC. D.Not suitable for LC.This provided clinicians the basis for patient selection.Comparing with the sur.gical findings,the coincidence rate of B-mode ultrasonography was 97.8%.Preoperative B-mode ul-trasonography of gall bladder has significant clinical value to relieve the patients from pain,decrease the operative risk and conversion rate of LC.
5.Screen and analysis of FVIII inhibitors in 167 hemophilia A patients.
Xiao-hong LIU ; Hua-fang WANG ; Rui YANG
Chinese Journal of Hematology 2011;32(9):627-629
Adolescent
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Adult
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Child
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Factor VIII
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genetics
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metabolism
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Hemophilia A
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blood
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diagnosis
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Humans
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Male
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Young Adult
6.Effects of glycyrrhizic acid beverage on exercise performance of fe- male undergraduates with moderate endurance training and its mechanism.
Jing QU ; Hong-fang YANG ; Xiao-hui WANG
Chinese Journal of Applied Physiology 2016;32(1):31-33
Beverages
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Exercise
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Female
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Glycyrrhizic Acid
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pharmacology
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Humans
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Physical Endurance
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Students
7.Clinical study of the influence on marginal bone levers when open healing of implants with platform ;switching
Shulan XU ; Shuo YANG ; Xijuan XIAO ; Xianglong DING ; Fang JIA
The Journal of Practical Medicine 2016;32(12):2020-2022
Objective The study examined the influence on marginal bone levers at implants which implants were assigned to open healing and implant-abutment connection restored according to a platform-switching concept. Methods One implant were placed in the first molar of mandible of 48 patients , randomly assigned to open (OH) or submerge (SH) healing. Standardized radiographs were obtained after implant surgery, when implant transfer and crown mounting, and 6 ,12 and 24 months after implants restoration, then evaluated for implant-bone-lever alterations(ΔIBL). Results After 6 months after implants restoration,ΔIBL were (-0.25 ± 0.08)mm mm(OH)and (-0.26 ± 0.12)mm(SH). After 12 months follow-up, ΔIBL were (-0.29 ± 0.13)mm (OH)and (-0.31 ± 0.14) mm(SH), and after 24 months later, ΔIBLwere (-0.34 ± 0.15)mm(OH)and (-0.33 ± 0.11)mm (SH). Conclusions Platform-switched implants showed very limited peri-implant bone-lever alterations. The healing-mode neither affected the total amount nor the temporal patterns of ΔIBL.
8.The distinguishing of gastric cancer associated genes by digital gene expression displayer using serial analysis of gene expression database
Fang XIONG ; Daguang XIAO ; Zhaoyang ZENG ; Wei XIONG ; Juhua YANG
Journal of Chinese Physician 2001;0(03):-
Objective To proceed deep data mining in large database obtained by Cancer Genome Anatomy Project and to distinguish the difference expression genes of gastric carcinoma.Methods The 300,783 serial analysis of gene expression records from 4 libraries of gastric cancer and 2 libraries of normal gastric tissue in database of the Cancer Genome Anatomy Project were analyzed by digital gene expression displayer.Results The 201 difference expression tags represented 136 genes(54 up-regulated and 82 down-regulated) and 65 ESTs(24 up-regulated and 41 down-regulated) were distinguished,and these genes were involved in biological process and signal transduction pathways,such as cell cycle regulation,cell proliferation and apoptosis.The gene expression profile in whole body normal and cancer tissues of PTMA were constructed by digital Northern based on serial analysis of gene expression database and by virtual Northern based on cDNA database,respectively.Conclusion The difference expression genes of gastric cancer can be distinguished effectively with bioinformatics,and the results will guide our further molecular biology research.If validated by molecular biology experiment,the difference expression genes will be used as molecular targets of gastric carcinoma.
9.Effect of Jiawei Xiaoyaosan on monoamine neurotransmitter in patients with psychological stress insomnia
Biyun XU ; Yan LI ; Fang XIAO ; Biyang OU ; Zhimin YANG
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(06):-
0.05).Conclusions:The integrated medicine can regulate monoamine neurotransmitter to some extent.
10.Study on changes of protein kinase C activity in peripheral blood T lymphocytes of children with idiopathic thrombocytopenic purpura and its clinical significance
Chanlin WU ; Fang LIU ; Hong XIAO ; Qun CHEN ; Xiaomeng YANG
Chinese Journal of Clinical Laboratory Science 2006;0(01):-
Objective To investigate the changes of protein kinase C(PKC) activity in peripheral blood T lymphocytes of the children with idiopathic thrombocytopenic purpura (ITP) and the relationships between PKC activity and T lymphocytes activation and thrombocyte decrease.Methods Sterilized peripheral blood were collected from ITP children (n=35) and healthy children (n=30).T lymphocytes were isolated and purified by the T cell segregation enrichment column.The total PKC activity was detected by non-radioactive assay.FasL,the T cell activated marker,was determined by flow cytometer.Platelet count was performed by hematocytometer.Result Compared with healthy children,total PKC activity in ITP children was significantly enhanced (0.97?0.21 nmol/min.ml vs 0.60? 0.13 nmol/min.ml,?s,P