1.Effect of zige lyophilized powder for injection in improving acute cerebral microcirculation disturbance in rats.
Yuan-Hong SHANG ; Hong-Jin WANG ; Jin-Feng TIAN ; Cong-Cong ZHANG ; Xiao-Na ZHANG ; Xiao-Yu XU
China Journal of Chinese Materia Medica 2014;39(4):733-737
OBJECTIVETo investigate the effect of Zige lyophilized powder for injection in improving the acute cerebral microcirculation disturbance in rats.
METHODWindow craniotomy was performed for rats after the drug administration for 14 days. The experimental microcirculation disturbance model was duplicated with high molecule dextran. After the drug administration, the micro-vein diameters of cerebral pla mater of various groups were observed and recorded under the biological microscope. The blood flow volume was monitored by laser Doppler flow-meter. HCT was measured by the electric resistance method. The hemorheological indexes were detected by the auto-hemorheological instrument.
RESULTZige lyophilized powder for injection (16.40, 32.70, 65.40 mg x kg(-1)) could significantly expand the micro-vein diameter of cerebral pla mater, improve the downward trend of the blood flow volume, and reduce the various hemorheological indexes.
CONCLUSIONZige lyophilized powder for injection shows the effect in improving the cerebral microcirculation.
Animals ; Brain ; blood supply ; drug effects ; Brain Ischemia ; drug therapy ; physiopathology ; Cerebrovascular Circulation ; drug effects ; Drugs, Chinese Herbal ; administration & dosage ; Humans ; Male ; Powders ; administration & dosage ; Rats ; Rats, Sprague-Dawley
2.Changes of renin-angiotensin-aldosterone system in workers exposed to noise
WU Qi feng LI Qi ping LI Cong LIANG Wei hui LI Bin LI Wan li DENG Xiao feng
China Occupational Medicine 2022;49(06):640-644
Objective - ( )- ( )
To observe the effects of renin angiotensin Ang aldosterone system RAAS in workers exposed to
Methods - -
occupational noise. Forty five workers with suspected occupational noise induced deafness were selected as noise
, ,
exposure group using convenient sampling method. According to their tinnitus symptom noise exposure intensity and work age
- , ,
they were divided into no tinnitus and tinnitus subgroups <90 dB and ≥90 dB subgroups work years <10 years and ≥10 years
subgroups. Another 45 workers with no occupational noise exposure history were selected as control group. The levels of plasma
( ), , ,
renin activity PRA AngⅠ AngⅡ and aldosterone of the two groups were detected and the aldosterone to renin activity
Results
ratio was calculated. The diastolic blood pressure of the noise exposure group was higher than that of the control group
[( )vs( ) ,P ] ,
80±7 76±8 mmHg <0.05 . However there was no significant difference in systolic blood pressure between the two
(P ) ( :
groups >0.05 . The level of plasma AngⅡ in the noise exposure group was higher than that in the control group median
vs ,P ) ( P )
100.98 65.43 μg/L <0.05 . There was no statistical significance in other indexes between the two groups all >0.05 . The
( :
plasma AngⅡ level in < 90 dB subgroup in the noise exposure group was higher than that of the control group median 123.16
vs ,P )
65.43 μg/L <0.05 . There was no statistical significance in other indexes among the two subgroups of tinnitus symptom or
( P )
work age in the noise exposure group and the control group all >0.05 . There were no significant differences in the abnormal
, ( P )
rates of PRA AngⅡ and aldosterone in plasma between the noise exposure group and the control group all >0.05 .
Conclusion
Occupational noise exposure may affect RAAS and lead to increased plasma AngⅡ levels in the workers.
-
Tinnitus and work age may not affect RAAS in occupational noise exposure workers.
3.Changes of renin-angiotensin-aldosterone system in workers exposed to noise
WU Qi feng LI Qi ping LI Cong LIANG Wei hui LI Bin LI Wan li DENG Xiao feng
China Occupational Medicine 2022;49(06):640-644
Objective - ( )- ( )
To observe the effects of renin angiotensin Ang aldosterone system RAAS in workers exposed to
Methods - -
occupational noise. Forty five workers with suspected occupational noise induced deafness were selected as noise
, ,
exposure group using convenient sampling method. According to their tinnitus symptom noise exposure intensity and work age
- , ,
they were divided into no tinnitus and tinnitus subgroups <90 dB and ≥90 dB subgroups work years <10 years and ≥10 years
subgroups. Another 45 workers with no occupational noise exposure history were selected as control group. The levels of plasma
( ), , ,
renin activity PRA AngⅠ AngⅡ and aldosterone of the two groups were detected and the aldosterone to renin activity
Results
ratio was calculated. The diastolic blood pressure of the noise exposure group was higher than that of the control group
[( )vs( ) ,P ] ,
80±7 76±8 mmHg <0.05 . However there was no significant difference in systolic blood pressure between the two
(P ) ( :
groups >0.05 . The level of plasma AngⅡ in the noise exposure group was higher than that in the control group median
vs ,P ) ( P )
100.98 65.43 μg/L <0.05 . There was no statistical significance in other indexes between the two groups all >0.05 . The
( :
plasma AngⅡ level in < 90 dB subgroup in the noise exposure group was higher than that of the control group median 123.16
vs ,P )
65.43 μg/L <0.05 . There was no statistical significance in other indexes among the two subgroups of tinnitus symptom or
( P )
work age in the noise exposure group and the control group all >0.05 . There were no significant differences in the abnormal
, ( P )
rates of PRA AngⅡ and aldosterone in plasma between the noise exposure group and the control group all >0.05 .
Conclusion
Occupational noise exposure may affect RAAS and lead to increased plasma AngⅡ levels in the workers.
-
Tinnitus and work age may not affect RAAS in occupational noise exposure workers.
4.Hypereosinophilic syndrome in a 2 month-old infant.
Xiao-ran AN ; Xing-guo WANG ; Jing-hua CHEN ; Xiao-feng YUAN ; Li CONG ; Ji-fang WANG ; Guang-shen LI
Chinese Journal of Pediatrics 2003;41(5):378-378
Anemia
;
etiology
;
Erythema
;
etiology
;
Fatal Outcome
;
Female
;
Fever
;
etiology
;
Humans
;
Hypereosinophilic Syndrome
;
complications
;
diagnosis
;
Infant
5.Research progress of anti-tumor in situ gel delivery system
Cong-cong XIAO ; Chen-fei LIU ; Jing FENG ; Li-qing CHEN ; He-ming ZHAO ; Ming-ji JIN ; Zhong-gao GAO ; Wei HUANG
Acta Pharmaceutica Sinica 2023;58(10):3004-3015
Cancer is the most important leading cause of death worldwide, with about 10 million deaths caused by cancer in 2020.
6.Comparative and phylogeny analysis of Asarum caudigerum and A. cardiophyllum complete chloroplast genomes
Guo-qing BAI ; Yuan LU ; Qian WEI ; An-cheng LIU ; Ren-na LI ; Xiao-feng CONG ; Jun-hui ZHOU ; Chen CHEN
Acta Pharmaceutica Sinica 2023;58(5):1364-1371
The complete chloroplast genome of medicinal plant
7.Uniformity of Coptidis Rhizoma decoction pieces dispensing based on effective constituent equivalence.
Qin DONG ; Jia-bo WANG ; Ding-kun ZHANG ; Wu-wen FENG ; Cong-en ZHANG ; Ming NIU ; Xiao-ping DONG ; Xiao-he XIAO
China Journal of Chinese Materia Medica 2015;40(20):3981-3986
Traditional Chinese medicine (TCM) dispensing is the final step of TCM used for clinical treatment, the stability of TCM dispensing is the guarantee of good clinical effect. Establishment of effect-constituent equivalence for Chinese herbal pieces based on clinical efficacy, can not only guarantee the stability of TCM dispensing, but also relate to the precision of clinical effect. This study chose Coptidis Rhizoma as the model, established effect-constituent equivalence of Coptidis Rhizoma, based on the effect-constituent index already established by our research group, and taking into consideration of homogeneity of clinical dosage and compliance of decoction, the uniformity of dispensing for different specification of Coptidis Rhizoma decoction pieces was studied. This research model was then applied to guide the specification-optimization of Coptidis Rhizoma and its clinical dispensing. The result indicated, effective constituent equivalence could reflect the fluctuation of specification, dosage and decoction to the fluctuation of efficacy; Optimized Coptidis Rhizoma decoction pieces had the characteristic of high homogeneity as for clinical dispensing, good compliance as for decoction, and high effective constituent equivalence. In conclusion, effective constituent equivalence could improve relevance of methods of TCM dispensing control to clinical effect. Preparated Superior-standard Decoction Pieces based on effective constituent equivalence was featured by good quality and a good practice of adjustable dosage, which could promote the development of TCM decoction pieces toward precision medicine.
Chemistry, Pharmaceutical
;
methods
;
Coptis
;
chemistry
;
Drugs, Chinese Herbal
;
chemistry
;
Quality Control
;
Rhizome
;
chemistry
;
Therapeutic Equivalency
8.Comparison of efficacy between bridge wire splints and Bryant traction for the treatment of femoral shaft fractures in children.
Yan ZHOU ; Xin-cong QU ; Zu-yi FANG ; Xiang LIU ; Xiao-hui PAN ; Feng FENG
China Journal of Orthopaedics and Traumatology 2011;24(3):236-239
OBJECTIVETo compare clinical effects between bridge wire splint fixation and traditional Bryant traction for the treatment of femoral shaft fractures in children.
METHODSFrom June 2006 to June 2009,38 children with femoral shaft fractures were treated with bridge wire splint fixation and Bryant traction. In bridge wire splint group, there were 15 males and 6 females, ranging in age from 8 months to 5.3 years, with an average of (2.3 +/- 0.6) years. According to fracture site classification, 5 patients were upper 1/3 femoral fractures, 9 patients were middle 1/3 femoral fractures,and 7 patients were lower 1/3 femoral fractures. In Bryant traction group,there were 10 males and 7 females, ranging in age from 10 months to 3.2 years, with an average of (2.2 +/- 0.4) years. According to fracture site classification, 4 cases were upper 1/3 femoral fractures, 10 patients were middle 1/3 femoral fractures, 3 patients were lower 1/3 femoral fractures. The clinical features, X-ray healing time,weight-bearing time and complications of the two groups were compared.
RESULTSComparison of fracture healing time: bridge wire splint group was (6.0 +/- 0.3) weeks and Bryant traction group was (6.2 +/- 0.4) weeks; the time of weight-bearing in bridge wire splint group was (6.1 +/- 1.0) weeks and in Bryant traction group was (6.4 +/- 1.2) weeks; there was no significant difference between two groups. There was a significant difference in soft tissue complication between bridge wire splint group occurred in 3 cases and 13 cases in Bryant traction group. According to the criteria of clinical efficacy,in Bryant traction group, 12 patients got an excellent result, 4 good and 1 fair; in bridge wire splint group, the data were 17, 3 and 1 respectively,and there was no significant difference between the two groups.
CONCLUSIONBoth of bridge wire splint fixation and traditional Bryant traction for the treatment of femoral shaft fractures in children have good efficacy. Compared with Bryant traction,bridge wire splint fixation is simple, safe and has reliable effect.
Child, Preschool ; Female ; Femur ; diagnostic imaging ; injuries ; physiopathology ; surgery ; Fracture Fixation ; adverse effects ; instrumentation ; Fractures, Bone ; diagnostic imaging ; physiopathology ; surgery ; Humans ; Infant ; Male ; Postoperative Complications ; Splints ; Time Factors ; Tomography, X-Ray Computed ; Traction ; methods ; Treatment Outcome ; Weight-Bearing
9.Three fixation instruments for Schatzker Ⅵ tibial plateau fractures :a biomechanical comparison
Hanzing MAO ; Yi LUO ; Guo-Ping SHEN ; Hua SUN ; Xiao-Feng ZHANG ; Jun-Wu HUANG ; Cong-Feng LUO ; Yi-Jin WANG ;
Chinese Journal of Primary Medicine and Pharmacy 2006;0(08):-
Objective To compare the biomechanical effect of three fixation instruments for SchatzkerⅥtibial plateau fractures.Methods Twenty four fresh knee specimens were made into models of SchatzkerⅥtibial plateau fractures.The specimens were divided randomly into three groups.Group A were fixed with a lateral periar- ticular plate and a posteromedial antiskid plate,and group B with a lateral periarticutar plate and an anteromedial lim- ited contact dynamic compression plate(LC-DCP),and group C with a lateral periarticular plate and a medical exter- nal fixator.Each model was tested for its biomechanical performance in resisting compression,bending and rotation. Results The performance of group B was higher than group A in anti-compression,anti-bending and anti-rotation, and group C was the poorest,there was no significant difference between group A and group B,and there was signifi- cant difference between group B and group C.Conclusion The biomechanical performance of group B was good. The method might have clinical applications in the treatment of SchatzkerⅥtibial plateau fractures.
10.Aryl hydrocarbon receptor interacting protein gene and familial isolated pituitary adenomas.
Feng CAI ; Yi-dan ZHANG ; Cong-xin DAI ; Xiao-hai LIU ; Ya-kun YANG ; Yong YAO ; Ren-zhi WANG
Acta Academiae Medicinae Sinicae 2012;34(6):640-644
Familial isolated pituitary adenoma (FIPA) is an autosomal dominant disease, characterized by low penetrance, early-onset disease, more invasive tumor growth, as well as somatotroph and lactotroph adenomas in most cases. It has been indicated that the aryl hydrocarbon receptor interacting protein (AIP) gene is a tumor suppressor gene. Many heterozygous mutations have been discovered in AIP in about 20% of FIPA families. However, the exact molecular mechanism by which its disfunction promotes tumorigenesis of pituitary is unclear.
Growth Hormone-Secreting Pituitary Adenoma
;
genetics
;
Humans
;
Intracellular Signaling Peptides and Proteins
;
genetics
;
Mutation
;
Pituitary Neoplasms
;
genetics