Adult ; Echinococcosis ; Heart Diseases ; parasitology ; Humans ; Male

Dental Prosthesis, Implant-Supported ; Humans ; Oral Hygiene ; Quality of Life

Objective To study the impacts of leukocytes elevation on the sperm quality and oxidative stress .Methods A total of 52 elevated leukocytes specimen and 50 normal leukocytes specimen were collected .Standard semen analysis was performed .Re-active oxygen species (ROS) production was measured using luminol as the probe by the Chemiluminescence method .Malonalde-hyde(MDA) content in semen was measured by the sulfo-barbitone acid method .Total superoxide dismutase(T-SOD) in semen was measured by the xanthine oxidase method .Results The semen parameters including total motility (P= 0 .008) ,progressive motility (P= 0 .005) and normal forms (P= 0 .003) ,the sperm motion parameters including mean curvilinear velocity (VCL)(P= 0 .023) , mean straight-line velocity (VSL)(P= 0 .010) ,mean average path (VAP)(P= 0 .011) ,swing(WOB)(P< 0 .001)in the elevated leu-kocytes group all decreased significantly compared with the normal leukocytes group .The ratio of sperm abnormality in the abnor-mal leukocytes group increased significantly (P= 0 .008) .ROS levels (using the log-transformation) and Malondialdehyde (MDA ) were significantly higher in the elevated leukocytes group ,but no significant difference was observed for T-SOD between the two groups(P> 0 .05) .Conclusion The leukocytes elevation could result in the decrease of spermatozoa quality ,which might be related with ROS increase .

Objective: To observe the efficacy of stereotactic radiotherapy combined with gemzar for treatment of unresectable pancreatic cancer.Methods: Gemzar at dose of 1000mg/m 2,28 days per cycle,drug was given at 1,8,15 days,for two cycles.After 24 hours all patients were treated with stereotactic radiotherapy.Per fraction was 5～7G Y,three times per week.The total dose was 40～48G Y.Results: 13 patients were followed up for one year,symptoms were reduced and median survival was 12 months.Conclusion: Stereotactic radiotherapy combined with gemzar has important valves for unresectabal pancreatic cancer.

This paper briefly analyzed and discussed the current status and major scientific challenges of traditional Chinese medicine (TCM) formulaology research. To promote formulaology research, a new strategy and corresponding technology, network formulaology, were proposed to reveal the complex interaction between functional chemome and biological responses network. The research framework and directions of network formulaology were also summarized and prospected.
Chemistry, Pharmaceutical ; methods ; standards ; Drugs, Chinese Herbal ; chemistry ; Internet ; Medicine, Chinese Traditional ; standards

Hepatoid adenocarcinoma of the stomach ( HAS) belongs to one of the rare cases in gastric cancer types ,which has extremely high malignant degree and poor prognosis .Lymph node metastasis and liver me-tastasis are common in HAS.In this article,we reported alpha-fetoprotein-high-producing hepatoid adenocar-cinoma of the stomach(HAS),and reviewed the related literature at home and abroad in order to improve clinical physicians understanding of these diseases and treatment experience .

Objective:To establish a liquid chromatography-mass spectrometry(LC-MS) method for determining the concentration of amlodipine besylate in human plasma and to evaluate the bioequivalence of 2 kinds of amlodipine besylate tablets.Methods: Twenty healthy male volunteers were enrolled into a single crossover study.A single dose of the suspension equivalent to 10 mg amlodipine besylate or a reference preparation was given in a crossover way.The plasma concentrations of amlodipine besylate were determined by LC-MS method in the volunteers at different time points;the pharmacokinetic parameters and relative bioavailability were calculated and the bioequivalence of the 2 preparations were evaluated.Results: The pharmacokinetic parameters for experimental and the reference preparations were: C_max(6.21?1.88) vs(6.03?1.08) ng/ml;AUC_0-120(250.68?52.61) vs(246.14?52.11) ng h/ml;T_max(6.0?2.3) vs(6.1? 2.5) h;t_1/2(40.45?6.68) vs(43.74?9.05) h,respectively.The linear range of the present method was 0.1-20.0 ng/ml;the lowest detectable concentration of amlodipine besylate was 0.1 ng/ml.There was no significant difference in pharmacokinetic parameters between the 2 tablets.Conclusion: The present method is simple to use,fast,and accurate.The 2 preparations of amlodipine besylate are bioequivalent.

Objective We aimed to evaluatd the effect of oral nursing with oral washing on patients with peroral endotracheal intubation and discuss the appropriate oral nursing method for patients with patients with peroral endotracheal intubation. Methods We chose 150 patients with indwelling peroral endotracheal intubation after neurosurgery and divided them into the control group (73 cases) and the test group (77 cases). The test group received oral nursing with oral washing while the control group with routine oral nursing method. We compared the incidence of halitosis, the moist degree of oral cavity and the amount of the tooth fungus spot between the two groups. Results The incidence of halitosis and the amount of the tooth fungus spot in the test group were lower than those of the control group; The moist degree of oral cavity in the test group was higher than that of the control group, P<0.01. Conclusions Oral washing could effectively control halitosis, keep oral cavity moist and prevent the formation of tooth fungus spot.

Adult ; Faculty ; Female ; Humans ; Male ; Middle Aged ; Sampling Studies ; Sleep ; Surveys and Questionnaires ; Young Adult

Adenoma, Oxyphilic ; classification ; pathology ; Carcinoma, Renal Cell ; classification ; metabolism ; pathology ; Humans ; Kidney ; pathology ; Kidney Neoplasms ; classification ; genetics ; pathology ; therapy ; Molecular Biology ; methods ; trends