Hormones ; pharmacology ; Humans ; Nephrotic Syndrome ; drug therapy ; Prednisone ; administration & dosage ; Recurrence

An HPLC method was established to simultaneously determine the five sesquiterpene lactones, carabrone, carabrol, 2-desoxy-4-epi-pulchellin, telekinand 11(13)-dehydroivaxillin in Carpesium abrotanoides. Samples were analyzed on a kromasil C18 column (4.6 mm x 250 mm, 5 µm); mobile phase: A was acetonitrile, B was water, with gradient elution; flow speed: 1.0 mL · min(-1); detection was carried out using a photodiode array detector at 211 nm; temperatureof column: 30 °C. The five sesquiterpene lactones were well separated with good linear correlations in the range of 0.270-2.700 (r = 0.999 7 ), 1.336-13.360 (r = 0.999 6), 0.258-2.580 (r = 0.999 7), 0.238-2.380 (r = 0.999 9), 0.490-4.900 µg (r = 0.999 9) for carabrone, carabrol, 2-desoxy-4-epi-pulchellin, telekin and 11 (13) -dehydroivaxillin. The average recoveries of these five sesquiterpene lactoneswere 96.78%-98.41% (RSD 1.3%-2.9%). The method was simple, repeatable and stable, which could be used for quality control of C. abrotanoide.
Asteraceae ; chemistry ; Chromatography, High Pressure Liquid ; methods ; Drugs, Chinese Herbal ; analysis ; Lactones ; analysis ; Sesquiterpenes ; analysis

Antineoplastic Agents ; therapeutic use ; Benzenesulfonates ; therapeutic use ; Humans ; Leukemia, Myeloid, Acute ; drug therapy ; Niacinamide ; analogs & derivatives ; Phenylurea Compounds ; Pyridines ; therapeutic use

To study the chemical constituents from Zanthoxylum simulans and their anti-inflammatory activity. The constituents of Z. simulans were isolated and purified using various column chromatographies. Their chemical structures were elucidated using extensive spectroscopic methods. The compounds were assayed inhibitory activity against NO production in LPS stimulated RAW 264.7 cells. Four compounds were obtained from the ethanol extract of Z. simulans and determined to be isozanthpodocarpin B(1), kobusin (2), (+)-fargesin (3), and epieudesmin (4). Compound 1 exhibited NO production inhibitory effect with IC50 value of 14.49 µmol · L(-1). Compound 1 is a new dimeric lignan and may be serve as potential anti-inflammatory agent in the future.
Animals ; Anti-Inflammatory Agents ; pharmacology ; Cells, Cultured ; Dimerization ; Lignans ; chemistry ; isolation & purification ; pharmacology ; Mice ; Nitric Oxide ; antagonists & inhibitors ; Zanthoxylum ; chemistry

Objective To investigate the situation of subjective well-being feeling of type 2 diabetes patients and its influential factors.Methods One hundred and twenty-seven patients with type 2 diabetes were recruited as our subjects and all of them were performed the questionnaire investigation about well-being feeling.Influential factors were analyzed through several statistic methods.Results The index of subject wellbeing ranged from 3.70 to 13.70 and the average was 10.67 ± 2.10 of all type 2 diabetes patients.Of which The index of total affectation was 5.11 ± 0.92 and the range was from 2.63 to 6.63.The score of life satisfaction was 5.58 ± 1.22,and the range was from 1.10 to 7.70.Index of subjective well-being significantly associated with education,family income,therapy approach,HbA1 c level,complication,medicine burden.However there was no correlation with gender,age,diabetes duration.Conclusion The main types of subjective well-being feeling of patients with type 2 diabetes were positive effect and positive experience.Many factors could be the influence factor to well-being.Measures should be taken to improve Subjective well-being of type 2 diabetes patients.

Objective To investigate the MRS characteristic of low T_2 signal in peripheral zone of prostatitis and prostatic carcinoma(Pca) and to evaluate the role of MRS in the discrimination of prostatitis and Pca.Methods After biopsy,24 patients with Hypointense T_2 signal in prostatic peripheral zone were divided into two groups:prostatitis and Pca.3D MRS was performed on the low T_2 area of peripheral zone to measure the ratio of(Cho+Cre)/Cit.Results The mean ratio of(Cho+Cre)/Cit in low T_2 area of prostatitis was 0.98?0.17,whereas that of Pca was 1.41?0.31,statistically significant difference was detected(t=8.89,?

Objective To characterize the MR imaging findings in different types of neuronal ceroid lipofuscinosis (NCL) in childhood. Methods Six children with NCL and 6 age-matched control subjects were examined by using MRI. There was 2 patients with infantile NCL, 2 with late-infantile NCL, and 2 with juvenile NCL. Results The cerebral atrophy was found in patients with infantile NCL, but the cerebellar atrophy was found in patients with late-infantile NCL and juvenile NCL; Hyperintensity in the centrum semiovale or periventricular white matter on T 2WI was revealed in all cases; Decreased T 2 signal was seen in the thalami in five patients, except for 1 juvenile NCL; Decreased T 2 signal in the basal ganglia was seen in the 2 case with late-infantile NCL. No abnormal change was found in the control subjects. Conclusion MRI is of great value in demonstrating the early changes of NCL. MRI especially facilitates the classification and early diagnosis of NCL.

In this article we analyzed the current development of moxibustion treating rheumatoid arthritis from the usefulness, advancement, synergistic effect as well as the variance between different kind of moxibustion. We concluded that moxibustion was an effective intervention for treating RA, and the methods used in moxibustion were searched in clinic. But the clinical tralls has a long way to go, we should pay more attention to the critical issues while in the use of moxibustion.

Objective　To detect the features of MRI of children leukodystriphies and to provide a heplful method for clinical diagnosis.Methods　The MRI examination was performed in 50 children with leukodystrophies and the cerebral lobes and cerebral special structures involved by lesions were analyzed.Results　1.There were dominant signs of involving parietal and occipital lobes in ALD,besides the two lobes,the frontal lobe was also involved easily in MLD.All lobes were involved in CD and PMD,and frontal lobe was involved in AD early.The central white matter was involved mainly in ALD,but the central white matter was involed only in MLD and the periphery white matter was spared.The central and periphery white matter were all involved in CD,PMD and AD.Furthermore,the cerebellar white matter is also easily involved in ALD and CD.2.The splenium of corpus callosum was mainly involved in ALD,and the splenium,body and knee of corpus callosum were all involved in MLD.But in CD,PMD and AD,the corpus callosum was spared.The back of the posterior limb of internal capsule was involved in ALD,but the all posterior limb of internal capsule was involved in MLD,and the all internal capsule was involved in CD and PMD.On external capsule,ALD involves its posterior part,but CD and PMD involve its all section.A prominet feature of ALD was involving the corticospinal tract of stem and other leukodystrophies don′t involve the corticospinal tract of stem beside one case later-onset GLD.In addition,the lateral lemmiscus was involved easily in ALD,and thalamus was also involved in ALD,MLD and PMD.Conclusion　As a noninvasive,safe and sensitive method,MRI can be used to find the leukodystrophies early.There are relatively characteristic features in different leokodystrophies,which is useful to clinical diagnosis.

Objective To study MR findings in 20 children aged from 10 months to 14 years with mitochondrial encephalomyopathy.Methods MRI evaluations were done in 20 children with mitochondrial encephalomyopathy proved by muscle biopsy and biochemical laboratory examinations.Results Brain parenchymal lesions in all cases were low signal intensity on T 1-weighted and high signal intensity on T 2-weighted images.Brain atrophy was showed in different degrees in 8 children.18 patients had involvement of gray matter,10 had only the deep gray matter involved and 4 cases had both the deep gray matter and the cerebral cortex involved simultaneously.4 patients showed deep gray matter abnormalities and cerebral infarction with involvement of cortex and subcortical white matter.2 patients had exclusively involvement of white matter,which were nonspecific white matter changes of the trigonal area.Conclusion MRI findings in mitochondrial encephalomyopathy are varied when gray matter especially deep gray matter involved,brain atrophy,untypical infarction and involvement of peripheral white matter are showed on MR,and associated with a variety of neuromuscular symptoms in children mitochondrial encephalomyopathy should be consider.