Objective To quantitatively evaluate the thickness of the buccal cortical bone in the posterior region of the maxillary for orthodontic micro‐implants in children .Methods Forty children (20 males and 20 females) in permanent dentition with Class Ⅱdivision 1 malocclusion were selected .The maxillary posterior alveolar bones of the subjects were scanned and reconstructed by cone‐beam computed tomography (CBCT) .The thickness of the cortical bone between the dental roots of the second upper premolar and the first upper molar at the height of 3 ,4 ,5 ,6 ,7 ,8 ,9 mm from the alveolar crest were determined .The data were analyzed sta‐tistically .Results The thickness of the cortical bone between the second upper premolar and the first upper molar was minimum at the height of 4 mm from the alveolar crest(P<0 .05) .The thickness of the cortical bone increased along with the distance increas‐ing from the alveolar crest at the height of 5 mm .The cortical bones in male were significantly thicker than those in female at the height of 7 ,8 ,9 mm (P<0 .05) .Conclusion The thickness of the buccal corticalbone in children in permanent dentition with ClassⅡ division 1 malocclusion changes with the measured vertical position .Micro‐implant anchorage is better to be placed in the area with a distance of 5 mm from the alveolar crest .

BACKGROUND:In recent years, prolift mesh pelvic materials have been widely used in the pelvic floor reconstruction. Scholars have been exploring the advantages and disadvantages of the prolift mesh pelvic reconstruction and the traditional hysterectomy for pelvic floor reconstruction. ＜br> OBJECTIVE:To systemical y assess prolift mesh pelvic reconstruction versus traditional hysterectomy for pelvic floor reconstruction. ＜br> METHODS:Wanfang, VIP, PubMed, Medline databases were searched for randomized control trials (RCTs) related to the clinical effectiveness of prolift mesh pelvic reconstruction versus traditional hysterectomy for pelvic floor reconstruction published from 1996 to 2014. Meta analysis of acquired data was performed through the use of RevMan5.2 software. ＜br> RESULTS AND CONCLUSION:Nine RCTs involving 780 patients were included. Of the 780 patients, 398 received prolift mesh pelvic reconstruction and 382 underwent traditional hysterectomy. Compared with, prolift mesh pelvic reconstruction was superior to the traditional hysterectomy group in terms of operative time, intraoperative bleeding, hospitalization duration, evacuation time, postoperative body temperature, and cure rate of 18 months (P＜0.05). However, there were no significant differences in the post-void residual volume, recurrence rate, the cure rate of 6 months and 12 months, quality of sexual life after 1 year postoperatively (P>0.05). These results reveal that the prolift mesh pelvic reconstruction exhibits better short-term effects on the pelvic floor dysfunction, but its long-term effects need to be further verified.

Objective:To Compare root resorption between T loop technique and sliding technique of orthodontic treatment.Meth-ods:90 patients with Angle class I malocclusion were orthodontically treated by MBT fixed appliances with T loop technique(n =45) and sliding technique(n =45)respectively.Root resorption of the patients were examined by grading evaluation method with orthopan-tomography and periapical films before and after orthodontic treatment.Results:After orthodontic treatment the tooth root resorption rate increased(P <0.05),the root resorption rate was not significantly different between T loop technique group and sliding technique group(P >0.05).Root resorption mostly occurred in the incisors,especially in mandibular tooth.Conclusion:There is no difference of the effect of root resorption between T loop technique and sliding technique of orthodontic treatment in patients with Angle class I malocclusion.

Separation of complex mixtures needs more resolving power. In two dimensional liquid chromatography (2D LC), the sample is subjected to two different separation conditions or mechanisms, which significantly increases the peak capacity,resolving power and reduces peak overlap. Meanwhile, 2D separation is more reliable for peak i-dentification from run to run than single-dimension chromatography, because two independent elution times are ob-tained for each peak. Among different 2D liquid chromatographic combinations/configurations, online comprehensive 2D-LC has appeared to be very attractive due to its high peak capacity, minimal sample loss, good reproducibility, and easy to automation, especially for separation of very complex samples. The present review discusses the theoreti-cal aspects and hardware configuration of online 2D-LC, particularly online comprehensive 2D-LC. It highlights its concept, features, advantages, applications and prospective in TCM quality Control analysis.

Objective To evaluate the clinical effect of levofloxacin combined with Jingangteng particle in the treatment of patients with chronic pelvic inflammatory disease.Methods According to the random number table, sixty -four patients with chronic pelvic inflammatory disease were divided into control group(n =32)which were treated with levofloxacin and treatment group(n =32)which were treated with levofloxacin and Jingangteng particle for three weeks.The clinical effect,symptoms and signs were evaluated and the adverse reactions between the two groups were observed as well as serum C reactive protein(CRP)were measured before and after treatment.Results The score of symptoms and signs of the treatment group were significantly lower than the control group,the difference was statistically significant [(2.61 ±2.09 )points vs.(5.32 ±3.28)points,t =3.941,P =0.000;(1.47 ± 1.02)points vs.(2.56 ±2.04)points,t =2.703,P =0.008].The level of serum CRP of the control group was (5.46 ± 1.93)mg/L,which was statistically higher than (3.76 ±1.06)mg/L of the treatment group after treatment,the differ-ence was statistically significant (t =4.367,P =0.000).The total effective rate of the treatment group was 96.9%, which of the control group was 78.1%,the difference between the two groups were statistically significant(χ2 =5.142,P =0.023).There was no significant adverse reactions during the treatment.Conclusion Levofloxacin com-bined with Jingangteng particle can obviously improve the symptoms and signs of chronic pelvic inflammatory disease, they have good safety and are worthy of clinical popularization and application.

Objective To get new more sensitive signs reflecting cartilage degeneration,which were added to the present ARA differential criteria of knee osteoarthritis and to compare the sensitivity and specificity before and after new items.Methods Through review analysis of the clinical feature,radiography and operative presentation of 115 adult patients,the new signs reflecting cartilage degeneration as items were found,which were added to the present ARA differential criteria of knee osteoarthritis as new criteria.Then the 112 patients who have received either knee joint replacement or arthroscopy were re diagnosed with both the present ARA criteria and the new criteria.Sensitivity and specificity were calculated and compared.Results "Extensive knee joint tenderness" with cartilage degradation and "lockage on motion or a positive Apler test" were significantly related to the meniscus degradation.A 39 7% sensitivity of these patients was obtained using the present ARA clinical criteria,while it reached 70 6% using the new clinical criteria ( P 0 05).Conclusion The two new items added to the present ARA criteria help to increase the sensitivity for diagnosis of knee osteoarthritis without influence on the specificity.

Objective To study the correlation of expression of N-myc downstream regulated gene 1(NDRG1) with invasion of breast invasive duct carcinoma and lymph node metastasis. Methods A total of 71 specimens including 26 case of primary breast invasive duct carcinoma with lymphnode metastasis,45 case of nonmetastasis breast invasive duct carcinoma were observed.NDRG1 was detected by immunohistochemistry in formalin-fixed and paraffin-embedded sections.At the same time,the correlations of NDRG1 with E-cad,MMP2,MMP9,and TIMP2 were investigated. Results The expression of NDRG1 in breast cancer with metastasis of lymph nodes(9/26) was lower than that of non-metastasis of lymph nodes(32/45)(P

Objective To establish alcoholic liver disease (ALD) model of rats. Method Rats were given wine by ig for 13 weeks. ALD were assessed by the level of serum glutamic-pyruvic transaminase (ALT), glutamic oxalacetic transaminase (AST), malonaldehyde (MDA) and pathological changes of liver. Result Over-dose wine can increase the level of serum ALT, AST, and MDA, decrease the level of serum albumin (ALB), and induce hepatic steatosis. Conclusion Alcoholic liver disease model of rats can be established by long-time and over-dose wine. The model can be applied in the research of ALD.

Recently,the incidence rate of small cell lung cancer in elderly patients has been increasing . The mainly therapeutic approach of small cell lung cancer consists of radiotherapy ,chemotherapy and surgery ,with the treatment purpose of prolonging survival time and improving life quality .As the huge development of accurate radiotherapy technology occurred in the past a few years ,radiotherapy could play more and more important roles in the treatment with elderly patients .Yet,there is no unified standards of treatment for small cell lung cancer in eld-erly patients.Therefore,we give a review on the latest processes and research on the treatment of small cells lung cancer in elderly patients .

AIM: To investigate the association between cycloxygenase-2 (COX-2) expression and VEGF intervention as well as the inhibitory effect of Meloxicam on the cultured human pterygium fibroblasts (HPF).METHODS: Expression of COX-2 was measured by immunohistochemistry in the cultured HPF from twenty excised pterygium cases. Expression of COX-2 in HPF was measured by Western blot following the treatment of vascular endothelial growth factor (VEGF) at the different concentrations. In addition, the effect of Meloxicam on proliferation of HPF was studied by adding the different concentrations into the cultured HPF plates by Mono-nuclear cell direct cytotoxicity (MTT) reduction assay.RESULTS: COX-2 expression was present in the cultured HPF. The level of the expression increased following VEGF treatment. The proliferation of the cultured HPF decreased following addition of the different concentrations of Meloxicam (from 75μ mol/L to 300μ mol/L) and the magnitude of the inhibition was dose-time dependent.CONCLUSION: COX-2 levels in the cultured HPF werepositively associated with VEGF stimulation and Meloxicam was inhibitory to HPF proliferation.