1.Genotype of hantavirus in Zhejiang province
Fang XU ; Ping-Ping YAO ; Han-Ping ZHU ; Jie WHANG ; Lei QIAN ; Qun HU ; Shu-Mei TONG ; Xiao-Seng DENG ; Rong-Hui XIE ; Zhang-Nv YANG ; Yun ZHANG ; Zhi-Yong ZHU
Chinese Journal of Experimental and Clinical Virology 2012;26(5):344-347
Objective To identify the genotype and clades of hantavirus (HV) in Zhejiang province.Methods The partial S and M segment of the HV in Zhejiang province were amplified with RTPCR using genotype-specific primers,and then were sequenced and compared with other known hantaviruses.Results The genotype of 11 strains were HTNV and other 7 strains were SEOV by homology and phylogenesis analysis,yet the clade distribution was significantly different among foci of Zhejiang with 5 clades of HTNV and 3 clades of SEOV.There also existed special clade of HTNV named ZNB-1,ZNB-2,A3 and of SEOV named Gou3,ZJ5.The homology of M segments of ZNB-1 and ZNB-2 with other HTNV clades were 69.7％-74.0％ except Nc167,A3 with other HTNV clades were 73.6％-76.3％ except B78.Conclusion Zhejiang province is co-circulating with HTN and SEO.Say the least of the clades are 5 of HTNV and 3 of SEOV and there also existed special clade of HTNV and SEOV.
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