1.Updated treatments of castration-resistant prostate cancer.
Yun-fei WEI ; Xiao-jian GU ; Qing-yi ZHU
National Journal of Andrology 2016;22(5):455-461
The diagnosis and treatment of prostate cancer are being improved due to the popularized screening of prostate specific antigen. Advanced prostate cancer, in spite of its response to androgen deprivation therapy, may finally develop into castration-resistant prostate cancer (CRPC) and shorten the overall survival of the patients. Many efforts have been made by worldwide researchers for new approaches to the management of CRPC, including new hormonal therapy, cytotoxic chemotherapy, immunotherapy, and bone metastasis-targeted therapy. This paper reviews the emerging agents undergoing clinical evaluation and drugs that have received approval for the treatment of CRPC in order to provide doctors and patients with more treatment options for CRPC and improve the overall survival rate and quality of life of the patients.
Androgen Antagonists
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Bone Neoplasms
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prevention & control
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Humans
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Immunotherapy
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Male
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Prostate-Specific Antigen
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blood
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Prostatic Neoplasms, Castration-Resistant
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therapy
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Quality of Life
2.A case of talcum pneumoconiosis.
Shi-qing YU ; Zu-yi ZHANG ; Xiao-ying HUANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(9):568-569
Humans
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Male
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Middle Aged
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Silicosis
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diagnosis
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therapy
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Talc
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adverse effects
3.Anaphylactic shock in a boy after taking oral ofloxacin.
Yan-ming GU ; Xiao-yi CHEN ; Yong-qing WANG
Chinese Journal of Pediatrics 2005;43(8):607-607
Administration, Oral
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Anaphylaxis
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chemically induced
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physiopathology
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therapy
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Anti-Bacterial Agents
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administration & dosage
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adverse effects
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Blood Pressure
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drug effects
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Child
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Diarrhea
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drug therapy
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Humans
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Male
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Ofloxacin
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administration & dosage
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adverse effects
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Treatment Outcome
4.Prenatal ultrasound diagnosis of otocephaly and review of the literatures
Ai-qing, ZHANG ; Xiao-xin, ZHANG ; Yi-qun, GU
Chinese Journal of Medical Ultrasound (Electronic Edition) 2013;(7):548-553
Objective To investigate the ultrasound characteristics of prenatal fetus otocephaly . Methods Three prenatal fetus with otocephaly were examined with two -and three-dimensional ultrasoundand examined results were compared with the those of induced labor or autopsy ,and ultrasound characteristicsof prenatal fetus were analyzed and summarized .Results The ultrasound performance of three prenatal fetuswith otocephaly and the examination of the appearance after induced labor showed :(1) The most intuitiveinitial sonographic performance of otocephaly was manifested by the absence of stomach bubble andoverabundance of amniotic fluid.Among three fetus,one fetus had overabundance of amniotic fluid at the midstageof pregnancy,one fetus had normal amniotic fluid at the mid-stage of pregnancy and one fetus hadextremely high amount of amniotic fluid and absence of stomach bubble at late stage of pregnancy .(2) Allthree fetus showed agnathy and synotia (shifts of both ears to the midline) and microstomia deformity.(3) All three fetus had associated complications with deformity in other systems including two cases of patients withcleft lip and palat,both were the fracture unilateral cleft lip derived from small mouth .One fetus withdysmelia and one fetus with complicated cardiovascular deformity and situs inversus and .(4) The results ofexamination after induced labor or autopsy were consistent with those of the prenatal ultrasound examination . Conclusions Prenatal ultrasound examination is an effective and feasible means for the diagnoses ofotocephaly.When the symptoms of “absence of stomach bubble and extremely high amount of amniotic fluid ”occurred,the fetal ear and submaxilla should be examined to confirm stand -alone otocephaly prenatally.
5.Selection of High-yield Agro-antibiotic 2-16 Producing Strain and Optimization of Its Cultivation
Xiao-Qing WANG ; Hong-Mei ZENG ; Yi-Ping SHI ;
Microbiology 1992;0(06):-
In order to improve the production of agro-antibiotic 2-16,the producing strain(Streptomyces ahygroscopicus var.huangshanensis) was treated by protoplast regeneration,ultraviolet radiation,NTG mutagenesis and low energy C~(+) ion implantation.At last,a high-yield strain No.515 was obtained.The production of ~()No.515 was increased by 223.10%.By using Plackett-Burman design and Response Surface Analysis provided by SAS software,the cultivation condition of No.515 was optimized.The amount of agro-antibiotic 2-16 was increased by 38.53% when the strain No.515 was cultivated in the optimum medium instead of the initial one.
6.Research advances in new technologies in targeted protein degradation
Jing-hong LIU ; Yi-min CHEN ; Xiao-qing CAI
Acta Pharmaceutica Sinica 2022;57(2):313-320
In recent years, the targeted protein degradation technology has developed quickly, with proteolysis-targeting chimera (PROTAC) as the best-known strategy through exploring the ubiquitin-proteasome system. A number of new targeted protein degradation strategies have been emerging to expand the scope of protein degradation technology, including lysosome-targeting chimeras (LYTACs), autophagy-targeting chimeras (AUTACs), autophagosome-tethering compounds (ATTECs) and chimeras based on chaperone-mediated autophagy (CMA). The emerging methodologies have explored another important protein degradation system in eukaryotes-lysosomal systems, such as the endosome-lysosome pathway and the autophagy-lysosome pathway. This review summaries the mechanisms and features of different strategies for targeted protein degradation, with a special emphasis on the new targeted protein degradation technologies, such as their current status, advantages and limitations.
7.Some Approaches for the Selective Isolation of Rare Actinomycetes
Wei XIAO ; Ming-Gang LI ; Xiao-Long CUI ; Yi-Qing LI ; Meng-Liang WEN ;
Microbiology 1992;0(01):-
The focus of microbiologists has moved to the rare actinomycetes.For selective isolation of rare actinomycetes that all play the important role in bioactive compounds,the approaches which involve the methods using gellan gum and flooding solution、 rehydration-centrifugation(RC)、 extremely high frequency radiation(EHF)、 bacteriophage and sucrose-gradient centrifugation were introduced in this paper.
8.Application and discussion of role-playing in medical immunology teaching for foreign students
Min YAO ; Yi-Hui FAN ; Yi-Qing ZHU ; Xiao-Yi SHAO ; Zhi-Yun BEN ; Xiao-Ying WANG
Chinese Journal of Immunology 2018;34(5):757-760
To study the application and effect of Role-playing in the teaching of Medical Immunology for foreign students.Role-playing method was tried using in the practical teaching of the pathway of complement activation and the related components in the"Medical Immunology" in Grade 2014(83 foreign students),and the teaching effect was analyzed and evaluated.In the study,we found that role-playing teaching method could not only help foreign students develop their initiative and comprehensively understand the difficulties of knowledge,but also cultivate their teamwork and interpersonal communication skills.At the same time,role-playing improved teaching efficiency and quality.Role-playing is a teaching method that meets the learning habits,characteristics,contents and rules of foreign students,which can improve the teaching quality and effect.
9.Comparative study on two polymerization methods for preparing ginsenoside Rg1 molecularly imprinted polymer separating materials.
Qing-Shan LIU ; Li-Na YI ; Ke-Qin LI ; Xiao-Ying YIN
China Journal of Chinese Materia Medica 2013;38(24):4287-4291
To obtain ginsenoside Rg1 molecularly imprinted polymer (MIP) separating materials with high selectivity, enrichment and adsorption performance through directional separation of ginsenoside Rg1 and analogues. In this study, MIPs were respectively prepared by precipitation polymerization and surface imprinted polymerization. Their adsorption performances were compared. The results showed that ginsenoside Rg1 MIPs prepared by the above two methods had a high adsorption performance to template molecules, with the maximum apparent adsorbing capacity of up to 27.74, 46. 80 mg x g(-1), respectively. Moreover, MIPs prepared by surface imprinted polymerization showed higher adsorption capacity than that by precipitation polymerization. The experimental results indicated that as for ginsenoside Rg1 with higher polarity, MIPs prepared by surface imprinted polymerization showed higher selectivity and adsorption performance, which provides provide important reference for preparing imprinted polymers with good adsorption performance with active molecules with strong polarity.
Adsorption
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Chemical Fractionation
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methods
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Chemical Precipitation
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Ginsenosides
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chemistry
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isolation & purification
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Molecular Imprinting
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Polymerization
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Polymers
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chemical synthesis
10.Endoscope-assisted partial-superficial parotidectomy without CO2 infusion.
Xiao-ming HUANG ; Yi-qing ZHENG ; Wei SUN
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2009;44(6):512-513
Adolescent
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Adult
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Endoscopy
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methods
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Female
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Humans
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Male
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Middle Aged
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Parotid Neoplasms
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surgery
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Salivary Glands
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surgery
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Young Adult