1.Study Progress on Embryonic Stem Cells and Adult Stem Cells Derivated into Male Germ Cells
Journal of Applied Clinical Pediatrics 2004;0(08):-
Embryonic stem cells(ESCs),a kind of totipotent cells,can differentiate into cell type of the 3 germ layers.Adult stem cells(ASCs) are pluripotent stem cells,which can self-renew and transdifferentiate into a completely different tissue derivative cells.Thus ASCs can transdifferentiate into germ cells in a certain condition.Great progress has made for the study on human ESCs.However,use of ESCs faces the immunological rejection,oncogenicity and ethical controversies problems,and these limit their uses for treatment of human diseases.On contrast,ASCs can advoid these problems,and they may have a better perspective.Germ cells as carriers of genetic materials,are worth of studying.If male germ cells can be derived from ASCs,this will open the possibilities for the use of these cells for male infertillty in clinical application.In this review,we will introduce the progress on derivation of male germ cells from ESCs and ASCs.
2.Reprogramming in origin and development of leukemia stem/progenitor cells.
Journal of Experimental Hematology 2009;17(5):1123-1126
The success of yielding induced pluripotent stem (iPS) cells from human somatic cells demonstrates the important role of reprogramming in the formation of stem/progenitor cells and initiates the exploration of the origin of leukemia stem cells. In our previous work, we have found two types of leukemia, bona fide leukemia and non-bona fide leukemia. Different leukemias originate from different leukemia stem/progenitor cells which are critical to the genesis and evolution of leukemia. Bona fide leukemia and non-bona fide leukemia originate from leukemia stem cells and progenitor cells, respectively. Recent research suggests that different types of leukemia are influenced by the reprogramming state of their origin cells.
Cell Differentiation
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Cellular Reprogramming
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Humans
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Induced Pluripotent Stem Cells
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Leukemia
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genetics
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Neoplastic Stem Cells
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Stem Cells
4.Functional multi-polarization of white blood cells and its significance.
Journal of Experimental Hematology 2010;18(1):1-6
Immune and hemopoiesis are one of basic project of experimental hematology. Immune function is a essential activity of white blood cells. It was puzzled for the diversity and complexity of immune response. Polarized immune response of immune cells was discovered 30 years ago, which facilitates the study on differentiation of lymphocyte. Recently recognition on multifunctional polarized immune response of lymphocyte and monocyte/macrophage would promote to elucidate the regulatory network of immune cells, diversity and complexity of immune response as well as the study on hemopoiesis. In this paper the approach of multifunctional polarized immune response of lymphocyte, monocyte/macrophage and dendritic cells were reviewed, and their role, especially in cytokine storm and tumor pro-inflammation condition were discussed.
Cell Differentiation
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Cytokines
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immunology
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Cytotoxicity, Immunologic
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Dendritic Cells
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cytology
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immunology
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Humans
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Monocytes
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cytology
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immunology
6.Treatment outcome of allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies not in remission.
Hai-Yan BAO ; Xiao-Jin WU ; Xiao MA
Chinese Journal of Oncology 2012;34(2):156-157
Adolescent
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Adult
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Disease-Free Survival
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Female
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Graft vs Host Disease
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etiology
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prevention & control
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Hematologic Neoplasms
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therapy
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Hematopoietic Stem Cell Transplantation
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adverse effects
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Humans
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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therapy
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Leukemia, Myeloid, Acute
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therapy
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Lymphocyte Transfusion
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Lymphoma, Non-Hodgkin
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therapy
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Male
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Middle Aged
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Recurrence
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Survival Rate
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Transplantation, Homologous
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Young Adult
7.Analysis of the Costs of Various Drugs Consumed in 36 Hospitals of Guangzhou in the Years 1997~ 2000
Qinghuan WU ; Xizhou XIAO ; Lingyan MA ; Caiyun CHEN
China Pharmacy 2001;12(5):285-286
OBJECTIVE: To analyze the trend of costs of various drugs consumed in hospitals of Guangzhou METHODS: The data were derived from the Hospital Purchasing of Drug Information System in Guangzhou from 1997 to 2000 The expense of each drug was calculated at the price of that year RESULTS: The annual increasing rates of drug expenses in 1998, 1999 and 2000 were 17 01% , 24 49% , 23 11% respectively CONCLUSION: It is a matter of great urgency to rationally use drugs, to eliminate the waste of resources and to lighten the patients'burden
8.Studies on the chemical constituents of the marine sponge Cina-chyrella australiansis from the South China Sea
Xuedong PENG ; Dingjun XIAO ; Songzhi DENG ; Weijie MA ; Houming WU
Chinese Journal of Marine Drugs 2000;0(06):-
Five compounds were isolated from the ethyl acetate extract of the marine sponge Cin-achyrella australiansis collected from the South China Sea. Their structures were identified by IR,1 H-NMR,13C-NMR,MS as the follows : 24-ethyl-cholest-4-en-3-one(Ⅰ), cholesterol (Ⅱ), benzene- ac-etamide(Ⅲ), p-hydroxyphenylacetamide(Ⅳ), indole-3-acetamide(Ⅴ).
9.Analysis of the Costs of Various Drugs Consumed in 36 Hospitals of Guangzhou in the Years 1997~2000
Qinghuan WU ; Xizhou XIAO ; Lingyan MA ; Caiyun CHEN
China Pharmacy 1991;0(05):-
OBJECTIVE:To analyze the trend of costs of various drugs consumed in hospitals of Guangzhou METHODS:The data were derived from the Hospital Purchasing of Drug Information System in Guangzhou from 1997 to 2000 The expense of each drug was calculated at the price of that year RESULTS:The annual increasing rates of drug expenses in 1998,1999 and 2000 were 17 01%,24 49%,23 11% respectively CONCLUSION:It is a matter of great urgency to rationally use drugs,to eliminate the waste of resources and to lighten the patients'burden
10.Apoptosis or necrosis, should which be expected for tumor cells?.
Ke-Fu WU ; Xiao-Tong MA ; Yu-Hua SONG
Journal of Experimental Hematology 2005;13(6):921-923
Evidence has indicated that low doses of anti-tumor regimens can induce cell apoptosis in vitro, although different regimens induce apoptosis by different mechanism and pathway. In recent years, new tumor treatment strategy has been mainly focused on inducing tumor cell apoptosis. The present review discusses the advantages and disadvantages of inducing tumor cell apoptosis. The benefit of inducing apoptosis is not to cause inflammatory reaction, but as its disadvantage, it inhibits immune responses, and the phagocytosis of apopotic bodies may result in horizontal transfer of genes (including oncogenes and other oncogenic materials), which can be one of the causes of tumor relapse. This paper proposes that the tumor treatment strategy should be turn into promoting tumor cell necrosis and inducing anti-tumor immune responses.
Antineoplastic Agents
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therapeutic use
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Apoptosis
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drug effects
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Humans
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Necrosis
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chemically induced
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Neoplasms
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drug therapy
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immunology
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pathology